Brom-ergocryptine in the Treatment of Phenothiazine-Induced Galactorrhoea

1975 ◽  
Vol 126 (3) ◽  
pp. 285-288 ◽  
Author(s):  
P. Beumont ◽  
J. Bruwer ◽  
B. Pimstone ◽  
A. Vinik ◽  
W. Utian
Keyword(s):  
Ergot Alkaloid ◽  
Plasma Prolactin ◽  
Hormonal Effect ◽  
Puerperal Lactation ◽  
Breast Secretion ◽  
Clinical Changes

An ergot alkaloid, 2-br-alpha-ergocryptine (CB 154), referred to hereafter as brom-ergocryptine, has been reported to inhibit puerperal lactation (Varga, Lutterbeck et al., 1972), and to terminate breast secretion in patients with inappropriate lactation (Lutterbeck, Pryor et al., 1971). Besser, Park et al. (1972) found that the drug suppressed elevated levels of plasma prolactin in five patients whose inappropriate lactation was due to a variety of causes. This hormonal effect was accompanied by clinical changes such as the disappearance of galactorrhoea, return of menstruation, and an increase in sexual potency.

scholarly journals Assessment of ergot (Claviceps purpurea) exposure in pregnant and postpartum beef cows

2018 ◽  
Vol 98 (4) ◽  
pp. 688-700 ◽  
Author(s):  
T. Grusie ◽  
V. Cowan ◽  
J. Singh ◽  
J. McKinnon ◽  
B. Blakley
Keyword(s):  
Ergot Alkaloid ◽  
Post Partum ◽  
Ergot Alkaloids ◽  
Maximum Size ◽  
Beef Cows ◽  
Plasma Prolactin ◽  
Claviceps Purpurea ◽  
Ambient Temperatures ◽  
Beef Cow ◽  
The Impact

Cows were fed ration for 9 wk containing 5, 48, 201, and 822 μg kg−1 ergot alkaloids. The objective was to evaluate the impact of ergot consumption in beef cow–calf operations. Ergot alkaloids up to 822 μg kg−1 did not alter the weight of peripartum and postpartum beef cows (P = 0.93) or nursing calves (P = 0.08), rectal temperature (P = 0.16), or plasma prolactin concentrations (P = 0.30) at moderate ambient temperatures. Ergot did not influence the time (>1 ng mL−1; P = 0.79) or the progesterone concentration (P = 0.38) at the time of first postpartum rise or the size of the first (14 ± 0.6 mm; P = 0.40) and second (13 ± 0.5 mm; P = 0.41) follicles to ovulate. The maximum size of the first postpartum corpus luteum (CL) was 4 mm larger in the 822 μg kg−1 ergot group compared with the control (P = 0.03) for the first ovulation post partum, but not for the second (P = 0.11). There was no effect of ergot exposure on the number of days until the appearance of the first (43 ± 4 d; P = 0.95) or second (52 ± 4 d; P = 0.98) CL post partum. Ergot alkaloid concentrations up to 822 μg kg−1 did not affect pregnancy rates (X2 = 0.36). In conclusion, ergot alkaloid exposure for 9 wk to concentrations as high as 822 μg kg−1 did not alter performance in pregnant and postpartum beef cattle at moderate ambient temperatures.

SUPPRESSION OF PUERPERAL LACTATION WITH AN ERGOT ALKALOID

1973 ◽  
Vol 28 (2) ◽  
pp. 97
Author(s):  
L. VARGA ◽  
P. M. LUTTERBECK ◽  
J. S. PRYOR ◽  
R. WENNER ◽  
H. ERB
Keyword(s):  
Ergot Alkaloid ◽  
Puerperal Lactation

Inhibition of Puerperal Lactation

1980 ◽  
Vol 25 (4) ◽  
pp. S95-S99 ◽  
Author(s):  
Sheila M. Walker
Keyword(s):  
General Treatment ◽  
Plasma Prolactin ◽  
Puerperal Lactation

Bromocriptine has been compared with an oestrogen and a placebo in the management of the inhibition of puerperal lactation. In addition to the resolution of symptoms, the effect on plasma prolactin levels has been studied. Of the regimes employed, bromocriptine was shown to have some advantage and a scheme indicating its place on the general treatment of this condition is outlined.

Bromocriptine - an important advance

1976 ◽  
Vol 14 (9) ◽  
pp. 33-34
Keyword(s):  
Ergot Alkaloid ◽  
Important Advance ◽  
Puerperal Lactation

Bromocriptine (Parlodel - Sandoz) is a semisynthetic ergot alkaloid marketed for the suppression of puerperal lactation and for treatment of galactorrhoea, amenorrhoea, impotence and infertility due to hyperprolactinaemia.

scholarly journals Suppression of Puerperal Lactation with an Ergot Alkaloid: A Double-blind Study

BMJ ◽  
1972 ◽  
Vol 2 (5816) ◽  
pp. 743-744 ◽  
Author(s):  
L. Varga ◽  
P. M. Lutterbeck ◽  
J. S. Pryor ◽  
R. Wenner ◽  
H. Erb
Keyword(s):  
Ergot Alkaloid ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Puerperal Lactation

Chronic treatment by the calcium channel blocker ± PN 200-110 in the rat counteracts the stimulations of pituitary weight, prolactin release and pituitary C-kinase activity induced by a chronic estradiol treatment, in vivo

1990 ◽  
Vol 122 (3) ◽  
pp. 403-408
Author(s):  
Ph. Touraine ◽  
P. Birman ◽  
F. Bai-Grenier ◽  
C. Dubray ◽  
F. Peillon ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Plasma Prolactin ◽  
Estradiol Treatment ◽  
Kinase C ◽  
Protein Kinase C Activity

Abstract In order to investigate whether a calcium channel blocker could modulate the protein kinase C activity in normal and estradiol pretreated rat pituitary, female Wistar rats were treated or not (controls) with ± PN 200-110 (3 mg · kg−1 · day−1, sc) for 8 days or with estradiol cervical implants for 8 or 15 days, alone or in combination with PN 200-110 the last 8 days. Estradiol treatment induced a significant increase in plasma prolactin levels and pituitary weight. PN 200-110 administered to normal rats did not modify these parameters, whereas it reduced the effects of the 15 days estradiol treatment on prolactin levels (53.1 ± 4.9 vs 95.0 ±9.1 μg/l, p<0.0001) and pituitary weight (19.9 ± 0.4 vs 23.0 ± 0.6 mg, p <0.001), to values statistically comparable to those measured after 8 days of estradiol treatment. PN 200-110 alone did not induce any change in protein kinase C activity as compared with controls. In contrast, PN 200-110 treatment significantly counteracted the large increase in soluble activity and the decrease in the particulate one induced by estradiol between day 8 and day 15. We conclude that PN 200-110 opposed the stimulatory effects of chronic in vivo estradiol treatment on plasma prolactin levels and pituitary weight and that this regulation was related to a concomitant modulation of the protein kinase C activity.

Pituitary and ovarian response to transient doe-litter separation in nursing rabbits

Reproduction ◽  
2000 ◽  
pp. 361-366 ◽  
Author(s):  
E Ubilla ◽  
PG Rebollar ◽  
D Pazo ◽  
AI Esquifino ◽  
JM Alvarino
Keyword(s):  
Pituitary Gland ◽  
Litter Size ◽  
Artificial Insemination ◽  
Ovarian Response ◽  
Major Effect ◽  
Free Access ◽  
Plasma Prolactin ◽  
Follicular Waves ◽  
Higher Sensitivity

The effects of a transient doe-litter separation on plasma prolactin, FSH and oestradiol concentrations, as well as the effect on LH response to exogenous GnRH administered at the time of artificial insemination, were determined in nursing rabbits. The effects on fertility, and litter size after parturition, as well as litter survival after doe-litter separation, were also studied. Control does (n = 12) had free access to nursing, whereas biostimulated does (n = 12) were separated from their litters for 48 h before artificial insemination. Plasma prolactin concentrations were decreased 24 h after the doe-litter separation (P < 0.05). The response of prolactin to suckling reached 10 times the basal values measured on day 10 after parturition (P < 0.0001). Increased oestradiol concentrations were found during the 48 h after the doe-litter separation: at 0 h, before artificial insemination (P< 0. 0001), 1.0-2.0 h after artificial insemination (P < 0.001), at 2.5 h (P < 0.05), 3.0 h (P < 0.01), and at 3.5 h (P < 0.05) after artificial insemination. Exogenous GnRH administered at the time of artificial insemination caused a greater LH response in does previously separated from their litters during 48 h (P < 0.01). The transient doe-litter separation did not affect plasma FSH concentrations, fertility, litter size or litter survival. These results suggest that a transient separation of nursing does from their litters before artificial insemination results in a decrease in plasma prolactin concentrations that could promote growth of follicular waves, and high steroidogenesis activity, leading to increased oestradiol concentrations and inducing higher sensitivity of the pituitary gland to exogenous GnRH. These findings associated to the absence of suckling episodes would lead to higher LH response and, therefore, exert a major effect on fertility.

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