A clinical comparison of phenelzine and electro-convulsive therapy in the treatment of depressive illness

1962 ◽  
Vol 108 (456) ◽  
pp. 708-710 ◽  
Author(s):  
W. J. Stanley ◽  
H. Fleming
Keyword(s):  
Mental Illness ◽  
Side Effects ◽  
Amine Oxidase ◽  
Depressive Illness ◽  
Oxidase Inhibitor ◽  
Convulsive Therapy ◽  
Clinical Comparison ◽  
Electro Convulsive Therapy

The mono-amine oxidase inhibitors, of which phenelzine (“Nardil”) is one example, were introduced for the treatment of depressive illness as a result of the observation that iproniazid, which is a mono-amine oxidase inhibitor, produced euphoria and increased mental alertness in some tuberculous patients to whom it was given. Trials of iproniazid in mental illness were carried out (Loomer et al., 1957; Cesarman, 1959), but it was found to be very liable to give rise to side-effects, being particularly toxic to the liver. Other less toxic mono-amine oxidase inhibitors such as phenelzine, which is chemically related to iproniazid, were later developed.

A PRELIMINARY INVESTIGATION OF STEROID EXCRETION IN DEPRESSED PATIENTS BEFORE AND AFTER ELECTRO-CONVULSIVE THERAPY

1964 ◽  
Vol 47 (1) ◽  
pp. 58-68 ◽  
Author(s):  
H. C. Ferguson ◽  
A. C. G. Bartram ◽  
H. C. Fowlie ◽  
D. M. Cathro ◽  
K. Birchall ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Normal Values ◽  
Preliminary Investigation ◽  
Depressive Illness ◽  
The Other ◽  
Convulsive Therapy ◽  
Before And After ◽  
The Individual ◽  
Steroid Excretion ◽  
Electro Convulsive Therapy

ABSTRACT Using a method dependent upon paper chromatography, the urinary excretion of the individual corticosteroids and the individual 17-oxosteroids has been studied before and after electro-convulsive therapy in five female patients suffering from a depressive illness. The corticosteroids, which are normally associated with stress, were found to show a fall in excretion from abnormally high levels before treatment to normal levels thereafter. The 11-deoxy-17-oxosteroids, on the other hand, showed a low level of excretion prior to treatment which was followed by a rise to normal values in clinical remission. These findings are discussed.

Intravenous Tranquillization with ECT

1975 ◽  
Vol 127 (6) ◽  
pp. 604-608 ◽  
Author(s):  
Joan Gomez ◽  
Peter Dally
Keyword(s):  
Side Effects ◽  
Recovery Time ◽  
Memory Impairment ◽  
Depression And Anxiety ◽  
Convulsive Therapy ◽  
Depressed Patients ◽  
Retrograde Memory ◽  
High Level ◽  
Electro Convulsive Therapy

SummaryForty depressed in-patients for whom electro-convulsive therapy had been prescribed were rated before treatment on depression and anxiety scales. Side effects, post-operative agitation and retrograde memory impairment were assessed in each patient after each of several treatments. Results were compared when no tranquillizer was given and when either diazepam or haloperidol was administered intravenously immediately before the anaesthetic. It was found than when ECT was given without tranquillization, the incidence and severity of post-operative agitation and of side effects were significantly greater in those patients with a high level of anxiety before treatment. Both diazepam and haloperidol were found to be effective in subduing agitation and side effects in anxious, depressed patients, but with diazepam recovery time was longer.

To the Editor

2002 ◽  
Vol 32 (7) ◽  
pp. 1321-1326 ◽  
Author(s):  
MAX FINK
Keyword(s):  
New York ◽  
Side Effects ◽  
Community Hospitals ◽  
Convulsive Therapy ◽  
Electro Convulsive Therapy

In analysing the results of a survey of electro-convulsive therapy (ECT) practice in Metropolitan New York community hospitals in 1997, Prudic et al. (2001) focus their attention on the psychological side-effects of ECT, and in so doing, ignore the reasons why ECT is given.

scholarly journals Development of new antidepressants

1997 ◽  
Vol 3 (1) ◽  
pp. 46-51 ◽  
Author(s):  
Eleni Palazidou
Keyword(s):  
Monoamine Oxidase ◽  
Turning Point ◽  
Monoamine Oxidase Inhibitor ◽  
Depressive Illness ◽  
Oxidase Inhibitor ◽  
Tricyclic Antidepressant ◽  
Antituberculous Drugs ◽  
One Year

The development of the first effective antidepressants in the late 1950s marked a turning point in the treatment of depressive illness. In 1957 the monoamine oxidase inhibitor (MAOI) iproniazid was discovered by chance, while searching for new antituberculous drugs. One year later the tricyclic antidepressant (TCA) imipramine was introduced, having been developed originally as an antipsychotic. A number of other drugs were subsequently added to these two groups of antidepressants, which dominated the field for the next three decades.

Sign in / Sign up

Export Citation Format

Share Document