scholarly journals Psychological therapies for treatment-resistant depression in adults: a Cochrane Review

2020 ◽  
Vol 26 (5) ◽  
pp. 254-254
Author(s):  
Sharea Ijaz ◽  
Philippa Davies ◽  
Catherine J. Williams ◽  
David Kessler ◽  
Glyn Lewis ◽  
...  
Keyword(s):  
Cochrane Review ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Psychological Therapies ◽  
Resistant Depression

Pharmacological interventions for treatment-resistant depression in adults: a Cochrane Review

2021 ◽  
Vol 28 (1) ◽  
pp. 2-3
Author(s):  
Philippa Davies ◽  
Sharea Ijaz ◽  
Catherine J. Williams ◽  
David Kessler ◽  
Glyn Lewis ◽  
...  
Keyword(s):  
Cochrane Review ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Pharmacological Interventions ◽  
Resistant Depression

Treatment-resistant depression: therapeutic options when first-line treatments fail

2021 ◽  
Vol 28 (1) ◽  
pp. 4-8
Author(s):  
Chloe Wigg ◽  
Sara Costi
Keyword(s):  
Antidepressant Treatment ◽  
Small Body ◽  
Cochrane Review ◽  
Treatment Resistant Depression ◽  
Long Term Effects ◽  
Treatment Resistant ◽  
Short Term ◽  
Augmentation Strategies ◽  
Resistant Depression

SUMMARYThe Cochrane review by Davies et al aimed to address the lack of clarity on the risks and benefits of switching and augmentation strategies in the pharmacological treatment of treatment-resistant depression in adults who did not respond (or partially responded) to at least 4 weeks of antidepressant treatment at a recommended dose. This commentary assesses their review and their conclusion that augmenting the current antidepressant with mianserin or with an antipsychotic improves depressive symptoms over the short-term (8 to 12 weeks). Their results need to be treated with caution owing to the small body of evidence and individual comparisons supported by one, two or three studies, the limited evidence on long-term effects and the significant gaps in the literature (e.g. a lack of studies assessing dose increases).

scholarly journals Psychological therapies for treatment-resistant depression in adults

2018 ◽  
Author(s):  
Sharea Ijaz ◽  
Philippa Davies ◽  
Catherine J Williams ◽  
David Kessler ◽  
Glyn Lewis ◽  
...  
Keyword(s):  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Psychological Therapies ◽  
Resistant Depression

Multimodal Therapy of Treatment Resistant Depression: A Study and Analysis

2005 ◽  
Vol 35 (1) ◽  
pp. 27-39 ◽  
Author(s):  
Noreen Bannan
Keyword(s):  
Multimodal Therapy ◽  
Self Esteem ◽  
Treatment Resistant Depression ◽  
Pharmacological Treatments ◽  
Treatment Resistant ◽  
Psychological Therapies ◽  
Therapeutic Trials ◽  
History Of ◽  
Resistant Depression

Objective: To demonstrate through the use of a case study, the application of cognitive psychotherapy in the treatment of resistant depression. Method: The case of a woman with an 18-month history of resistant depression associated with low self-esteem, guilt and shame, who failed to respond to three therapeutic trials of antidepressants is described. A detailed description of a CBT intervention over 12 sessions is given. Result: Clear improvements on assessments of mood and hopelessness, along with overall improvements in social and occupational functioning were noted. Conclusion: These improvements were attributed to a combination of CBT and pharmacotherapy, where pharmacotherapy alone failed to alleviate symptoms. A concise literature review revealed relatively few published trials of psychological treatments, and a lack of clear guidelines on pharmacological treatments. More research is needed to explore the efficacy of psychological therapies for treatment resistant depression.

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