scholarly journals Pharmacotherapy for obsessive—compulsive disorder

2011 ◽  
Vol 17 (6) ◽  
pp. 419-434 ◽  
Author(s):  
Naomi Fineberg ◽  
Angus Brown
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Pharmacological Treatment ◽  
Special Populations ◽  
Evidence Based ◽  
First Line ◽  
Obsessive Compulsive ◽  
Evidence Based Treatment ◽  
Compulsive Disorder ◽  
Augmentation Strategies ◽  
Treatment Refractory

SummaryWe present a narrative review of evidence-based treatment for obsessive–compulsive disorder (OCD), covering first-line pharmacological treatment, augmentation strategies, approaches for treatment-refractory OCD and the management of OCD in special populations (children and adolescents, pregnant and breast-feeding women, and elderly people).

scholarly journals Agomelatine Augmentation of Escitalopram Therapy in Treatment-Resistant Obsessive-Compulsive Disorder: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Domenico De Berardis ◽  
Nicola Serroni ◽  
Stefano Marini ◽  
Giovanni Martinotti ◽  
Francesca Ferri ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Chronic Condition ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Atypical Antipsychotics ◽  
Young Female ◽  
Treatment Resistant ◽  
First Line ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Augmentation Strategies

Obsessive-compulsive disorder (OCD) is a chronic condition characterized by obsessions or compulsions that cause distress or interfere with functioning. Selective serotonin reuptake inhibitors are the first-line strategy in the treatment of OCD, but approximately 40% to 60% of patients with OCD fail to respond to them. Several augmentation strategies have been proposed, including the use of atypical antipsychotics and antidepressant combinations. In the present paper we describe the case of a young female patient suffering from severe treatment-resistant OCD who remitted as a result of agomelatine augmentation of escitalopram therapy.

Treatments for Obsessive-Compulsive Disorder

2015 ◽  
Author(s):  
Darin D. Dougherty ◽  
Scott L. Rauch ◽  
Michael A. Jenike
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Behavior Therapy ◽  
First Line ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
First Line Therapy ◽  
Line Therapy ◽  
Augmentation Strategies ◽  
Overwhelming Evidence ◽  
Limited Support

There is overwhelming evidence of the most rigorous type supporting the efficacy of serotonin reuptake inhibitors (SRIs) in the treatment of obsessive-compulsive disorder (OCD). Along with SRIs, behavior therapy must be considered a viable first-line therapy. The best available data suggest that behavior therapy, and perhaps cognitive therapy, is at least as effective as medication in some instances and may be superior with respect to risks, costs, and enduring benefits. A variety of second-line medication treatments for OCD have been studied in a controlled or systematic fashion. Augmentation of SRIs with antipsychotics, buspirone, or clonazepam is provisionally recommended based on the available data. Other monotherapies and augmentation strategies find very limited support at present.

Dissemination of Evidence-Based Treatment for Pediatric Obsessive-Compulsive Disorder in the Southern Region of Brazil: Challenges and Future Directions

2014 ◽  
Vol 28 (3) ◽  
pp. 198-210
Author(s):  
Andrea Stachon ◽  
Isabela Machado da Silva
Keyword(s):  
Mental Health ◽  
Health System ◽  
Obsessive Compulsive Disorder ◽  
Behavioral Therapy ◽  
Current System ◽  
Public Mental Health ◽  
Evidence Based ◽  
Obsessive Compulsive ◽  
Evidence Based Treatment ◽  
Compulsive Disorder

Pediatric obsessive-compulsive disorder (OCD) is a prevalent condition that responds well to specialized treatment including cognitive behavioral therapy (CBT) or serotonin reuptake inhibitors or their combination. In Brazil, the dissemination of evidence-based treatment for pediatric OCD is hindered because of the peculiarities of the health system. The presence of a multitiered health system (public, insured, and private) with insufficient investment in public mental health and relative inaccessibility of insured/private care for most of the Brazilian population make the implementation of specialized OCD treatment centers largely unavailable in Brazil. Furthermore, lack of appropriate training in child mental health, CBT, and evidence-based approaches to OCD in current psychiatry and psychology training programs further impede improvement in diagnosis and treatment. The challenges faced in the current system in Brazil will be discussed and also strategies and programs that are currently being implemented in the south of Brazil to help address the gaps in treatment for pediatric patients with OCD.

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