scholarly journals The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells

2008 ◽  
Vol 84 (4) ◽  
pp. 973-980 ◽  
Author(s):  
Thomas Y. Wuest ◽  
Jami Willette-Brown ◽  
Scott K. Durum ◽  
Arthur A. Hurwitz
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Naturally Occurring ◽  
And Function

Effect of immunosuppressants on the expansion and function of naturally occurring regulatory T cells

2007 ◽  
Vol 18 (2) ◽  
pp. 94-100 ◽  
Author(s):  
Dong-Gyun Lim ◽  
In-Yi Joe ◽  
Youn-Hee Park ◽  
Sung-Ho Chang ◽  
Yu-Mee Wee ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Naturally Occurring ◽  
And Function

scholarly journals Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Cristian Doñas ◽  
Macarena Fritz ◽  
Valeria Manríquez ◽  
Gabriela Tejón ◽  
María Rosa Bono ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Trichostatin A ◽  
Gene Promoter ◽  
Treg Cells ◽  
Specific Subset ◽  
Global Increase ◽  
And Function ◽  
H3 Acetylation

Regulatory T cells are a specific subset of lymphocytes that suppress immune responses and play a crucial role in the maintenance of self-tolerance. They can be generated in the thymus as well as in the periphery through differentiation of naïve CD4+T cells. The forkhead box P3 transcription factor (Foxp3) is a crucial molecule regulating the generation and function of Tregs. Here we show that thefoxp3gene promoter becomes hyperacetylated inin vitrodifferentiated Tregs compared to naïve CD4+T cells. We also show that the histone deacetylase inhibitor TSA stimulated thein vitrodifferentiation of naïve CD4+T cells into Tregs and that this induction was accompanied by a global increase in histone H3 acetylation. Importantly, we also demonstrated that Tregs generated in the presence of TSA have phenotypical and functional differences from the Tregs generated in the absence of TSA. Thus, TSA-generated Tregs showed increased suppressive activities, which could potentially be explained by a mechanism involving the ectonucleotidases CD39 and CD73. Our data show that TSA could potentially be used to enhance the differentiation and suppressive function of CD4+Foxp3+Treg cells.

scholarly journals SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Xiaoyan Yu ◽  
Yimin Lao ◽  
Xiao-Lu Teng ◽  
Song Li ◽  
Yan Zhou ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
The Stability ◽  
And Function
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