scholarly journals Inhibition of caspase-8 activity promotes protective Th1- and Th2-mediated immunity to Leishmania major infection

2013 ◽  
Vol 95 (2) ◽  
pp. 347-355 ◽  
Author(s):  
Wânia F. Pereira-Manfro ◽  
Flávia L. Ribeiro-Gomes ◽  
Alessandra Almeida Filardy ◽  
Natália S. Vellozo ◽  
Landi V. C. Guillermo ◽  
...  
Keyword(s):  
Leishmania Major ◽  
Caspase 8 ◽  
Major Infection ◽  
Th1 And Th2

scholarly journals Inhibition of caspase-8 activity reduces IFN-gamma expression by T cells from Leishmania major infection

2008 ◽  
Vol 80 (1) ◽  
pp. 129-136 ◽  
Author(s):  
Wânia F. Pereira ◽  
Landi V.C. Guillermo ◽  
Flávia L. Ribeiro-Gomes ◽  
Marcela F. Lopes
Keyword(s):  
T Cells ◽  
T Cell ◽  
Lymph Nodes ◽  
Cd8 T Cells ◽  
Leishmania Major ◽  
Caspase 8 ◽  
Ifn Gamma ◽  
Major Infection ◽  
Draining Lymph Nodes

Following infection with Leishmania major, T cell activation and apoptosis can be detected in draining lymph nodes of C57BL/6-infected mice. We investigated the mechanisms involved in apoptosis and cytokine expression following Tcellactivation. After two weeks of infection, apoptotic T cells were not detected in draining lymph nodes but activation with anti-CD3 induced apoptosis in both CD4 and CD8 T cells. Treatment with anti-FasLigand, caspase-8 or caspase- 9 inhibitors did not block activation-induced T-cell death. We also investigated whether the blockade of caspase-8 activity would affect the expression of type-1 or type-2 cytokines. At early stages of infection, both CD4 and CD8 T cells expressed IFN-gamma upon activation. Treatment with the caspase-8 inhibitor zIETD-fmk (benzyl-oxycarbonyl-Ile- Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone) reduced the proportion of CD8 T cells and IFN-gamma expression in both CD4 and CD8T cells. We conclude that a non apoptotic role of caspase-8 activity may be required for T cell-mediated type-1 responses during L. major infection.

Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection

1991 ◽  
Vol 142 (1) ◽  
pp. 28-32 ◽  
Author(s):  
R.M. Locksley ◽  
F.P. Heinzel ◽  
B.J. Holaday ◽  
S.S. Mutha ◽  
S.L. Reiner ◽  
...  
Keyword(s):  
Leishmania Major ◽  
Major Infection ◽  
Th1 And Th2

scholarly journals CD4+CD25+ Regulatory T Cells Suppress Differentiation and Functions of Th1 and Th2 Cells, Leishmania major Infection, and Colitis in Mice

2003 ◽  
Vol 170 (1) ◽  
pp. 394-399 ◽  
Author(s):  
Damo Xu ◽  
Haiying Liu ◽  
Mousa Komai-Koma ◽  
Carol Campbell ◽  
Charlie McSharry ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Leishmania Major ◽  
Th2 Cells ◽  
Major Infection ◽  
Th1 And Th2

scholarly journals Cutaneous Leishmaniasis (Leishmania major Infection) in Dutch Troops Deployed in Northern Afghanistan: Epidemiology, Clinical Aspects, and Treatment

2010 ◽  
Vol 83 (6) ◽  
pp. 1295-1300 ◽  
Author(s):  
Pieter-Paul van Thiel ◽  
Wendy F. van der Meide ◽  
Allard van der Sluis ◽  
Jimmy E. Zeegelaar ◽  
Aldert Bart ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Major ◽  
Clinical Aspects ◽  
Major Infection

scholarly journals Deletion of the Aryl Hydrocarbon Receptor Enhances the Inflammatory Response to Leishmania major Infection

2011 ◽  
Vol 7 (9) ◽  
pp. 1220-1229 ◽  
Author(s):  
Guillermo Elizondo ◽  
Miriam Rodríguez-Sosa ◽  
Elizabet Estrada-Muñiz ◽  
Frank J. Gonzalez ◽  
Libia Vega
Keyword(s):  
Inflammatory Response ◽  
Aryl Hydrocarbon Receptor ◽  
Leishmania Major ◽  
Major Infection ◽  
Aryl Hydrocarbon

scholarly journals Histopathology of Leishmania major infection: revisiting L. major histopathology in the ear dermis infection model

2009 ◽  
Vol 104 (6) ◽  
pp. 918-922 ◽  
Author(s):  
Silvia Dantas Cangussú ◽  
Carolina Carvalho de Souza ◽  
Camila França Campos ◽  
Leda Quercia Vieira ◽  
Luís Carlos Crocco Afonso ◽  
...  
Keyword(s):  
Leishmania Major ◽  
Infection Model ◽  
Major Infection
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