scholarly journals Interleukin-4 biases differentiation of B cells from Trypanosoma cruzi-infected mice and restrains their fratricide: role of Fas ligand down-regulation and MHC class II-transactivator up-regulation

2003 ◽  
Vol 73 (1) ◽  
pp. 127-136 ◽  
Author(s):  
E. V. Acosta Rodriguez
Keyword(s):  
B Cells ◽  
Trypanosoma Cruzi ◽  
Mhc Class Ii ◽  
Fas Ligand ◽  
Class Ii ◽  
Interleukin 4 ◽  
Down Regulation ◽  
Class Ii Transactivator ◽  
Mhc Class Ii Transactivator

scholarly journals The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins

2021 ◽  
Vol 22 (3) ◽  
pp. 1074
Author(s):  
Jorge Alfonso León Machado ◽  
Viktor Steimle
Keyword(s):  
Gene Expression ◽  
Mhc Class Ii ◽  
Protein Interactions ◽  
Transcriptional Regulator ◽  
Class Ii ◽  
Class Ii Transactivator ◽  
Mhc I ◽  
Mhc Ii ◽  
Mhc Class Ii Transactivator

In this review, we discuss the major histocompatibility complex (MHC) class II transactivator (CIITA), which is the master regulator of MHC class II gene expression. CIITA is the founding member of the mammalian nucleotide-binding and leucine-rich-repeat (NLR) protein family but stood apart for a long time as the only transcriptional regulator. More recently, it was found that its closest homolog, NLRC5 (NLR protein caspase activation and recruitment domain (CARD)-containing 5), is a regulator of MHC-I gene expression. Both act as non-DNA-binding activators through multiple protein–protein interactions with an MHC enhanceosome complex that binds cooperatively to a highly conserved combinatorial cis-acting module. Thus, the regulation of MHC-II expression is regulated largely through the differential expression of CIITA. In addition to the well-defined role of CIITA in MHC-II GENE regulation, we will discuss several other aspects of CIITA functions, such as its role in cancer, its role as a viral restriction element contributing to intrinsic immunity, and lastly, its very recently discovered role as an inhibitor of Ebola and SARS-Cov-2 virus replication. We will briefly touch upon the recently discovered role of NLRP3 as a transcriptional regulator, which suggests that transcriptional regulation is, after all, not such an unusual feature for NLR proteins.

scholarly journals Aberrant Expression of Fas Ligand in Mice Deficient for the MHC Class II Transactivator

2002 ◽  
Vol 168 (9) ◽  
pp. 4414-4419 ◽  
Author(s):  
Tania S. Gourley ◽  
Dipak R. Patel ◽  
Kevin Nickerson ◽  
Soon-Cheol Hong ◽  
Cheong-Hee Chang
Keyword(s):  
Mhc Class Ii ◽  
Fas Ligand ◽  
Class Ii ◽  
Class Ii Transactivator ◽  
Aberrant Expression ◽  
Mhc Class Ii Transactivator

scholarly journals Class II transactivator regulates the expression of multiple genes involved in antigen presentation.

1995 ◽  
Vol 181 (2) ◽  
pp. 765-767 ◽  
Author(s):  
C H Chang ◽  
R A Flavell
Keyword(s):  
Antigen Presentation ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Class Ii Transactivator ◽  
Leukocyte Antigen ◽  
Expression Of Genes ◽  
Mhc Class Ii Transactivator ◽  
Mutant Cells ◽  
Mhc Class Ii Genes

CIITA (a major histocompatibility complex [MHC] class II transactivator) has been shown to be required for the expression of MHC class II genes in both B cells and interferon gamma-inducible cells. Here we demonstrate that CIITA not only activates MHC class II genes but also genes required for antigen presentation. Mutant HeLa cells, defective in the expression of classic MHC class II genes, invariant chain, and the newly described human histocompatibility leukocyte antigen-DM genes, were used to study the role of CIITA in the regulation of these genes. Upon transfection with CIITA cDNA, the mutant cells expressed all three genes, suggesting that CIITA is a global regulator for the expression of genes involved in antigen presentation.

scholarly journals The MHC Class II transactivator CIITA inhibits the persistent activation of NF-kB by Tax-1

Retrovirology ◽  
2015 ◽  
Vol 12 (S1) ◽  
Author(s):  
Greta Forlani ◽  
Rawan Abdallah ◽  
Luisa Guidali ◽  
Roberto S Accolla ◽  
Giovanna Tosi
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Class Ii Transactivator ◽  
Mhc Class Ii Transactivator

scholarly journals Revisiting the specificity of the MHC class II transactivator CIITA in classical murine dendritic cells in vivo

2017 ◽  
Vol 47 (8) ◽  
pp. 1317-1323 ◽  
Author(s):  
David A. Anderson ◽  
Gary E. Grajales-Reyes ◽  
Ansuman T. Satpathy ◽  
Carlos E. Vasquez Hueichucura ◽  
Theresa L. Murphy ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Class Ii Transactivator ◽  
Mhc Class Ii Transactivator
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