scholarly journals T cell contact-mediated activation of respiratory burst in human polymorphonuclear leukocytes is inhibited by high-density lipoproteins and involves CD18

2004 ◽  
Vol 77 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Philippe Cettour-Rose ◽  
Thi Xuan Khanh Nguyen ◽  
Lena Serrander ◽  
Marie-Thérèse Kaufmann ◽  
Jean-Michel Dayer ◽  
...  
Keyword(s):  
T Cell ◽  
Respiratory Burst ◽  
Polymorphonuclear Leukocytes ◽  
High Density ◽  
High Density Lipoproteins ◽  
Cell Contact ◽  
Human Polymorphonuclear Leukocytes

scholarly journals Blockade of T Cell Contact-Activation of Human Monocytes by High-Density Lipoproteins Reveals a New Pattern of Cytokine and Inflammatory Genes

PLoS ONE ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. e9418 ◽  
Author(s):  
Lyssia Gruaz ◽  
Céline Delucinge-Vivier ◽  
Patrick Descombes ◽  
Jean-Michel Dayer ◽  
Danielle Burger
Keyword(s):  
T Cell ◽  
High Density ◽  
High Density Lipoproteins ◽  
Cell Contact ◽  
Human Monocytes ◽  
Contact Activation ◽  
Inflammatory Genes

Role of myeloperoxidase in respiratory burst of human polymorphonuclear leukocytes

Inflammation ◽  
1985 ◽  
Vol 9 (1) ◽  
pp. 21-31 ◽  
Author(s):  
P. Dri ◽  
M. R. Soranzo ◽  
R. Cramer ◽  
R. Menegazzi ◽  
V. Miotti ◽  
...  
Keyword(s):  
Respiratory Burst ◽  
Polymorphonuclear Leukocytes ◽  
Human Polymorphonuclear Leukocytes

scholarly journals High-Density Lipoprotein from Chronic Kidney Disease Patients Modulates Polymorphonuclear Leukocytes

Toxins ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 73 ◽  
Author(s):  
Jana Raupachova ◽  
Chantal Kopecky ◽  
Gerald Cohen
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Systemic Inflammation ◽  
Oxidative Burst ◽  
Polymorphonuclear Leukocytes ◽  
Surface Expression ◽  
High Density ◽  
High Density Lipoproteins ◽  
Signal Transduction Inhibitors ◽  
Uremic Patients

The anti-inflammatory properties of high-density lipoproteins (HDL) are lost in uremia. These HDL may show pro-inflammatory features partially as a result of changed protein composition. Alterations of polymorphonuclear leukocytes (PMNLs) in chronic kidney disease (CKD) may contribute to chronic inflammation and high vascular risk. We investigated if HDL from uremic patients is related to systemic inflammation by interfering with PMNL function. PMNL apoptosis was investigated by assessing morphological features and DNA content. CD11b surface expression was quantified by flow cytometry. Oxidative burst was measured via cytochrome c reduction assay. Chemotaxis was assessed by using an under-agarose migration assay. We found that HDL from CKD and hemodialysis (HD) patients significantly attenuated PMNL apoptosis, whereas HDL isolated from healthy subjects had no effect on PMNL apoptosis. The use of signal transduction inhibitors indicated that uremic HDL exerts anti-apoptotic effects by activating pathways involving phosphoinositide 3-kinase and extracellular-signal regulated kinase. Healthy HDL attenuated the surface expression of CD11b, whereas HDL from CKD and HD patients had no effect. All tested isolates increased the stimulation of oxidative burst, but did not affect PMNL chemotactic movement. In conclusion, HDL may contribute to the systemic inflammation in uremic patients by modulating PMNL functions.

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