scholarly journals B cell receptor triggering sensitizes human B cells to TRAIL-induced apoptosis

2010 ◽  
Vol 88 (5) ◽  
pp. 937-945 ◽  
Author(s):  
Andre Ortlieb Guerreiro-Cacais ◽  
Jelena Levitskaya ◽  
Victor Levitsky
Keyword(s):  
B Cells ◽  
B Cell ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Human B Cells ◽  
Induced Apoptosis

scholarly journals Rewiring of B cell receptor signaling by Epstein–Barr virus LMP2A

2020 ◽  
Vol 117 (42) ◽  
pp. 26318-26327
Author(s):  
Kamonwan Fish ◽  
Federico Comoglio ◽  
Arthur L. Shaffer ◽  
Yanlong Ji ◽  
Kuan-Ting Pan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
B Cells ◽  
B Cell ◽  
Epstein Barr Virus ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Barr Virus ◽  
Human B Cells ◽  
Bcr Signaling ◽  
Epstein Barr

Epstein–Barr virus (EBV) infects human B cells and reprograms them to allow virus replication and persistence. One key viral factor in this process is latent membrane protein 2A (LMP2A), which has been described as a B cell receptor (BCR) mimic promoting malignant transformation. However, how LMP2A signaling contributes to tumorigenesis remains elusive. By comparing LMP2A and BCR signaling in primary human B cells using phosphoproteomics and transcriptome profiling, we identified molecular mechanisms through which LMP2A affects B cell biology. Consistent with the literature, we found that LMP2A mimics a subset of BCR signaling events, including tyrosine phosphorylation of the kinase SYK, the calcium initiation complex consisting of BLNK, BTK, and PLCγ2, and its downstream transcription factor NFAT. However, the majority of LMP2A-induced signaling events markedly differed from those induced by BCR stimulation. These included differential phosphorylation of kinases, phosphatases, adaptor proteins, transcription factors such as nuclear factor κB (NF-κB) and TCF3, as well as widespread changes in the transcriptional output of LMP2A-expressing B cells. LMP2A affected apoptosis and cell-cycle checkpoints by dysregulating the expression of apoptosis regulators such as BCl-xL and the tumor suppressor retinoblastoma-associated protein 1 (RB1). LMP2A cooperated with MYC and mutant cyclin D3, two oncogenic drivers of Burkitt lymphoma, to promote proliferation and survival of primary human B cells by counteracting MYC-induced apoptosis and by inhibiting RB1 function, thereby promoting cell-cycle progression. Our results indicate that LMP2A is not a pure BCR mimic but rather rewires intracellular signaling in EBV-infected B cells that optimizes cell survival and proliferation, setting the stage for oncogenic transformation.

scholarly journals B-cell-activating factor inhibits CD20-mediated and B-cell receptor-mediated apoptosis in human B cells

Immunology ◽  
2008 ◽  
Vol 125 (4) ◽  
pp. 570-590 ◽  
Author(s):  
Yohei Saito ◽  
Yoshitaka Miyagawa ◽  
Keiko Onda ◽  
Hideki Nakajima ◽  
Ban Sato ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
B Cell Activating Factor ◽  
Human B Cells

Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcγRIIb with Fc-engineered antibodies

2008 ◽  
Vol 45 (15) ◽  
pp. 3926-3933 ◽  
Author(s):  
Seung Y. Chu ◽  
Igor Vostiar ◽  
Sher Karki ◽  
Gregory L. Moore ◽  
Greg A. Lazar ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Human B Cells

SYK and LYN Mediate B-cell Receptor-independent Calcium-induced Apoptosis in DT-40 Lymphoma B-cells

2002 ◽  
Vol 43 (11) ◽  
pp. 2165-2170 ◽  
Author(s):  
De-Min Zhu ◽  
Heather E. Tibbles ◽  
Alexei O. Vassilev ◽  
Fatih M. Uckun
Keyword(s):  
B Cells ◽  
B Cell ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Induced Apoptosis

scholarly journals B Cell Receptor Engagement and T Cell Contact Inducebcl-6Somatic Hypermutation in Human B Cells: Identity with Ig Hypermutation

2000 ◽  
Vol 165 (2) ◽  
pp. 830-839 ◽  
Author(s):  
Hong Zan ◽  
Zongdong Li ◽  
Kozaburo Yamaji ◽  
Patricia Dramitinos ◽  
Andrea Cerutti ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
B Cell ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Cell Contact ◽  
Human B Cells

scholarly journals TGFβ Activated Kinase 1 (TAK1) at the Crossroad of B Cell Receptor and Toll-Like Receptor 9 Signaling Pathways in Human B Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96381 ◽  
Author(s):  
Dániel Szili ◽  
Zsuzsanna Bankó ◽  
Eszter Angéla Tóth ◽  
György Nagy ◽  
Bernadette Rojkovich ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Signaling Pathways ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Toll Like Receptor ◽  
Human B Cells
Sign in / Sign up

Export Citation Format

Share Document