Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson’s disease

2007 ◽  
Vol 82 (5) ◽  
pp. 1083-1094 ◽  
Author(s):  
Ashley D. Reynolds ◽  
Rebecca Banerjee ◽  
Jianou Liu ◽  
Howard E. Gendelman ◽  
R. Lee Mosley
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
T Cells ◽  
Regulatory T Cells

scholarly journals Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease

2010 ◽  
Vol 184 (5) ◽  
pp. 2261-2271 ◽  
Author(s):  
Ashley D. Reynolds ◽  
David K. Stone ◽  
Jessica A. L. Hutter ◽  
Eric J. Benner ◽  
R. Lee Mosley ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
T Cells ◽  
Regulatory T Cells ◽  
Th17 Cell ◽  
Dopaminergic Neurodegeneration ◽  
Nigrostriatal Dopaminergic Neurodegeneration

scholarly journals A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinson's disease induced by MPTP

2012 ◽  
Vol 165 (7) ◽  
pp. 2213-2227 ◽  
Author(s):  
Hyo Jin Son ◽  
Ji Ae Lee ◽  
Nari Shin ◽  
Ji Hyun Choi ◽  
Jai Woong Seo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model

scholarly journals Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet

2010 ◽  
Vol 299 (4) ◽  
pp. R1082-R1090 ◽  
Author(s):  
Jill K. Morris ◽  
Gregory L. Bomhoff ◽  
John A. Stanford ◽  
Paige C. Geiger
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
Locomotor Activity ◽  
Substantia Nigra ◽  
High Fat Diet ◽  
Model Assessment ◽  
High Fat

Despite numerous clinical studies supporting a link between type 2 diabetes (T2D) and Parkinson's disease (PD), the clinical literature remains equivocal. We, therefore, sought to address the relationship between insulin resistance and nigrostriatal dopamine (DA) in a preclinical animal model. High-fat feeding in rodents is an established model of insulin resistance, characterized by increased adiposity, systemic oxidative stress, and hyperglycemia. We subjected rats to a normal chow or high-fat diet for 5 wk before infusing 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle. Our goal was to determine whether a high-fat diet and the resulting peripheral insulin resistance would exacerbate 6-OHDA-induced nigrostriatal DA depletion. Prior to 6-OHDA infusion, animals on the high-fat diet exhibited greater body weight, increased adiposity, and impaired glucose tolerance. Two weeks after 6-OHDA, locomotor activity was tested, and brain and muscle tissue was harvested. Locomotor activity did not differ between the groups nor did cholesterol levels or measures of muscle atrophy. High-fat-fed animals exhibited higher homeostatic model assessment of insulin resistance (HOMA-IR) values and attenuated insulin-stimulated glucose uptake in fast-twitch muscle, indicating decreased insulin sensitivity. Animals in the high-fat group also exhibited greater DA depletion in the substantia nigra and the striatum, which correlated with HOMA-IR and adiposity. Decreased phosphorylation of HSP27 and degradation of IκBα in the substantia nigra indicate increased tissue oxidative stress. These findings support the hypothesis that a diet high in fat and the resulting insulin resistance may lower the threshold for developing PD, at least following DA-specific toxin exposure.

T cells and Parkinson's disease

2017 ◽  
Vol 16 (10) ◽  
pp. 769-771 ◽  
Author(s):  
R Lee Mosley ◽  
Howard E Gendelman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
T Cells

The key role of T cells in Parkinson's disease pathogenesis and therapy

2019 ◽  
Vol 60 ◽  
pp. 25-31 ◽  
Author(s):  
Jill K. Baird ◽  
Dennis Bourdette ◽  
Charles K. Meshul ◽  
Joseph F. Quinn
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
T Cells ◽  
Disease Pathogenesis
Sign in / Sign up

Export Citation Format

Share Document