scholarly journals Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection

2007 ◽  
Vol 83 (3) ◽  
pp. 755-764 ◽  
Author(s):  
Hye-Young Jeong ◽  
Youn-Jae Lee ◽  
Su-Kil Seo ◽  
Soo-Woong Lee ◽  
Sung-Jae Park ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
T Cell ◽  
Chronic Hepatitis C ◽  
T Cell Immunity ◽  
Hepatitis C Infection ◽  
Cell Immunity

scholarly journals Chronic hepatitis C viral infection subverts vaccine‐induced T‐cell immunity in humans

Hepatology ◽  
2016 ◽  
Vol 63 (5) ◽  
pp. 1455-1470 ◽  
Author(s):  
Christabel Kelly ◽  
Leo Swadling ◽  
Stefania Capone ◽  
Anthony Brown ◽  
Rachel Richardson ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
T Cell ◽  
Viral Infection ◽  
Chronic Hepatitis C ◽  
T Cell Immunity ◽  
Cell Immunity

scholarly journals T-cell immunity and hepatitis C virus reinfection after cure of chronic hepatitis C with an interferon-free antiviral regimen in a chimpanzee

Hepatology ◽  
2014 ◽  
Vol 60 (5) ◽  
pp. 1531-1540 ◽  
Author(s):  
Benoit Callendret ◽  
Heather B. Eccleston ◽  
Shelby Hall ◽  
William Satterfield ◽  
Stefania Capone ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Chronic Hepatitis C ◽  
T Cell Immunity ◽  
Cell Immunity

scholarly journals Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

2009 ◽  
Vol 83 (18) ◽  
pp. 9122-9130 ◽  
Author(s):  
Lucy Golden-Mason ◽  
Brent E. Palmer ◽  
Nasim Kassam ◽  
Lisa Townshend-Bulson ◽  
Stephen Livingston ◽  
...  
Keyword(s):  
T Cells ◽  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Viral Infection ◽  
Chronic Hepatitis C ◽  
Effector Memory ◽  
Hepatitis C Infection ◽  
Ligand Interaction

ABSTRACT A number of emerging molecules and pathways have been implicated in mediating the T-cell exhaustion characteristic of chronic viral infection. Not all dysfunctional T cells express PD-1, nor are they all rescued by blockade of the PD-1/PD-1 ligand pathway. In this study, we characterize the expression of T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) in chronic hepatitis C infection. For the first time, we found that Tim-3 expression is increased on CD4+ and CD8+ T cells in chronic hepatitis C virus (HCV) infection. The proportion of dually PD-1/Tim-3-expressing cells is greatest in liver-resident T cells, significantly more so in HCV-specific than in cytomegalovirus-specific cytotoxic T lymphocytes. Tim-3 expression correlates with a dysfunctional and senescent phenotype (CD127low CD57high), a central rather than effector memory profile (CD45RAnegative CCR7high), and reduced Th1/Tc1 cytokine production. We also demonstrate the ability to enhance T-cell proliferation and gamma interferon production in response to HCV-specific antigens by blocking the Tim-3-Tim-3 ligand interaction. These findings have implications for the development of novel immunotherapeutic approaches to this common viral infection.

scholarly journals Correction: A Crucial Role for Kupffer Cell-Derived Galectin-9 in Regulation of T Cell Immunity in Hepatitis C Infection

PLoS ONE ◽  
2010 ◽  
Vol 5 (3) ◽  
Author(s):  
John A. Mengshol ◽  
Lucy Golden-Mason ◽  
Tomohiro Arikawa ◽  
Maxwell Smith ◽  
Toshiro Niki ◽  
...  
Keyword(s):  
Hepatitis C ◽  
T Cell ◽  
Kupffer Cell ◽  
Crucial Role ◽  
T Cell Immunity ◽  
Hepatitis C Infection ◽  
Cell Immunity

scholarly journals Association of Chronic Hepatitis C Infection With T-Cell Phenotypes in HIV-Negative and HIV-Positive Women

2014 ◽  
Vol 67 (3) ◽  
pp. 295-303 ◽  
Author(s):  
Mark H. Kuniholm ◽  
Xianhong Xie ◽  
Kathryn Anastos ◽  
Robert C. Kaplan ◽  
Xiaonan Xue ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
T Cell ◽  
Chronic Hepatitis C ◽  
Hiv Positive ◽  
Hepatitis C Infection ◽  
Hiv Positive Women ◽  
T Cell Phenotypes ◽  
Cell Phenotypes ◽  
Hiv Negative
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