scholarly journals Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone marrow-derived dendritic cells in nonobese diabetic mice: from regulatory mechanism to clinical implication

2003 ◽  
Vol 75 (2) ◽  
pp. 293-306 ◽  
Author(s):  
Shu-Fen Wu ◽  
Tan-Mei Liu ◽  
Yu-Chun Lin ◽  
Huey-Kang Sytwu ◽  
Hsueh-Fen Juan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Clinical Implication ◽  
Regulatory Mechanism ◽  
Diabetic Mice ◽  
Decoy Receptor ◽  
Nonobese Diabetic ◽  
Decoy Receptor 3 ◽  
Nonobese Diabetic Mice ◽  
And Function

scholarly journals Transgenic Expression of Decoy Receptor 3 Protects Islets from Spontaneous and Chemical-induced Autoimmune Destruction in Nonobese Diabetic Mice

2004 ◽  
Vol 199 (8) ◽  
pp. 1143-1151 ◽  
Author(s):  
Hsiang-Hsuan Sung ◽  
Jyuhn-Huarng Juang ◽  
Yu-Chun Lin ◽  
Chien-Hung Kuo ◽  
Jung-Tung Hung ◽  
...  
Keyword(s):  
Fas Ligand ◽  
Therapeutic Potential ◽  
Autoimmune Diabetes ◽  
Dependent Manner ◽  
Diabetic Mice ◽  
Decoy Receptor ◽  
Nonobese Diabetic ◽  
Decoy Receptor 3 ◽  
Nonobese Diabetic Mice ◽  
Islet Transplants

Decoy receptor 3 (DCR3) halts both Fas ligand– and LIGHT-induced cell deaths, which are required for pancreatic β cell damage in autoimmune diabetes. To directly investigate the therapeutic potential of DCR3 in preventing this disease, we generated transgenic nonobese diabetic mice, which overexpressed DCR3 in β cells. Transgenic DCR3 protected mice from autoimmune and cyclophosphamide-induced diabetes in a dose-dependent manner and significantly reduced the severity of insulitis. Local expression of the transgene did not alter the diabetogenic properties of systemic lymphocytes or the development of T helper 1 or T regulatory cells. The transgenic islets had a higher transplantation success rate and survived for longer than wild-type islets. We have demonstrated for the first time that the immune-evasion function of DCR3 inhibits autoimmunity and that genetic manipulation of grafts may improve the success and survival of islet transplants.

scholarly journals Bone Marrow Precursors of Nonobese Diabetic Mice Develop into Defective Macrophage-Like Dendritic Cells In Vitro

2004 ◽  
Vol 173 (7) ◽  
pp. 4342-4351 ◽  
Author(s):  
Tatjana Nikolic ◽  
Marjolijn Bunk ◽  
Hemmo A. Drexhage ◽  
Pieter J. M. Leenen
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals Development and Function of Diabetogenic T-cells in B-cell-Deficient Nonobese Diabetic Mice

Diabetes ◽  
2001 ◽  
Vol 50 (4) ◽  
pp. 763-770 ◽  
Author(s):  
P. P.L. Chiu ◽  
D. V. Serreze ◽  
J. S. Danska
Keyword(s):  
T Cells ◽  
B Cell ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice ◽  
And Function
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