scholarly journals Mesenchymal properties of SJL mice-stem cells and their efficacy as autologous therapy in a relapsing–remitting multiple sclerosis model

2014 ◽  
Vol 5 (6) ◽  
pp. 134 ◽  
Author(s):  
Carmen Marin-Bañasco ◽  
Margarita García ◽  
Issac Guerrero ◽  
Rafael Sánchez ◽  
Guillermo Estivill-Torrús ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cells ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Autologous Therapy ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Multiple Sclerosis Model

Expression of cathepsins S and D signals a distinctive biochemical trait in CD34+ hematopoietic stem cells of relapsing–remitting multiple sclerosis patients

2013 ◽  
Vol 19 (11) ◽  
pp. 1443-1453 ◽  
Author(s):  
Sabata Martino ◽  
Simona Montesano ◽  
Ilaria di Girolamo ◽  
Roberto Tiribuzi ◽  
Maria Di Gregorio ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Specific Cell ◽  
Hematopoietic Stem ◽  
Biochemical Trait ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Multiple Sclerosis Patients ◽  
Relapsing Remitting Multiple Sclerosis

Background: The elucidation of mechanistic aspects of relapsing–remitting multiple sclerosis (RRMS) pathogenesis may offer valuable insights into diagnostic decisions and medical treatment. Results: Two lysosomal proteases, cathepsins S and D (CatS and CatD), display an exclusive pattern of expression in CD34+ hematopoietic stem cells (HSCs) from peripheral blood of acute MS (A-MS) patients ( n = 20). While both enzymes normally exist as precursor forms in the HSCs of healthy individuals ( n = 30), the same cells from A-MS patients consistently exhibit mature enzymes. Further, mature cathepsins are expressed at lower rates in stable MS subjects (S-MS, n = 15) and revert to precursor proteins after interferon-β1a treatment ( n = 5). Mature CatD and CatS were induced in HSCs of healthy donors that were either co-cultured with PBMCs of A-MS patients or exposed to their plasma, suggesting a functional involvement of soluble agents. Following HSC exposure to several cytokines known to be implicated in MS, and based on relative cytokine levels displayed in A-MS, S-MS and control individuals, we identified IL-16 as a specific cell signaling factor associated with cathepsin processing. Conclusions: These data point to an evident correlation between CatS and CatD expression and MS clinical stage, and define a biochemical trait in HSCs with functional, medical, and diagnostic relevance.

Effects of relapsing-remitting multiple sclerosis on the stomatognathic system: preliminary findings

2020 ◽  
Vol 179 (6) ◽  
Author(s):  
Gabriel Pádua da Silva ◽  
Marcelo Palinkas ◽  
Robson F. Tosta Lopes ◽  
Saulo C. Vallin Fabrin ◽  
Bruno Ferreira ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Stomatognathic System ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis
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