scholarly journals Human Wharton’s jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells

2013 ◽  
Vol 4 (3) ◽  
pp. 59 ◽  
Author(s):  
Tao Du ◽  
Xiangyu Zou ◽  
Jun Cheng ◽  
Shuai Wu ◽  
Liang Zhong ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Hepatocyte Growth Factor ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Renal Fibrosis ◽  
Wharton’S Jelly ◽  
Tubular Epithelial Cells ◽  
Wharton's Jelly ◽  
Hepatocyte Growth

Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action

2004 ◽  
Vol 287 (1) ◽  
pp. F7-F16 ◽  
Author(s):  
Youhua Liu
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Hepatocyte Growth Factor ◽  
Renal Fibrosis ◽  
Molecular Mechanisms ◽  
Mesangial Cells ◽  
Glomerular Mesangial Cells ◽  
Tubular Epithelial Cells ◽  
Mesenchymal Transition ◽  
Hepatocyte Growth

Hepatocyte growth factor (HGF) is a pleiotropic factor that plays an imperative role in tubular repair and regeneration after acute renal injury. Growing evidence indicates that HGF is also an endogenous renoprotective factor that possesses a potent antifibrotic ability. HGF prevents the initiation and progression of chronic renal fibrosis and inhibits transforming growth factor (TGF)-β1 expression in a wide variety of animal models. In vitro, HGF counteracts the action of TGF-β1 in different types of kidney cells, resulting in blockade of the myofibroblastic activation from interstitial fibroblasts and glomerular mesangial cells, as well as inhibition of the mesenchymal transition from tubular epithelial cells. Recent studies reveal that HGF antagonizes the profibrotic actions of TGF-β1 by intercepting Smad signal transduction through diverse mechanisms. In interstitial fibroblasts, HGF blocks activated Smad-2/3 nuclear translocation, whereas it specifically upregulates the expression of the Smad transcriptional corepressor SnoN in tubular epithelial cells. In glomerular mesangial cells, HGF stabilizes another Smad corepressor, TGIF, by preventing it from degradation. Smad corepressors bind to activated Smad-2/3 and sequester their ability to transcriptionally activate TGF-β target genes. This article reviews recent advances in our understanding of the cellular and molecular mechanisms underlying HGF inhibition of renal fibrosis.

scholarly journals Mesenchymal Stromal Cells Modulate Corneal Alloimmunity via Secretion of Hepatocyte Growth Factor

2019 ◽  
Vol 8 (10) ◽  
pp. 1030-1040 ◽  
Author(s):  
Sharad K. Mittal ◽  
William Foulsham ◽  
Sachin Shukla ◽  
Elsayed Elbasiony ◽  
Masahiro Omoto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Hepatocyte Growth

scholarly journals Data supporting that miR-92a suppresses angiogenic activity of adipose-derived mesenchymal stromal cells by down-regulating hepatocyte growth factor

Data in Brief ◽  
2016 ◽  
Vol 6 ◽  
pp. 295-310 ◽  
Author(s):  
Anastassia Efimenko ◽  
Georgiy Sagaradze ◽  
Zhanna Akopyan ◽  
Tatiana Lopatina ◽  
Natalia Kalinina
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Angiogenic Activity ◽  
Hepatocyte Growth

Hepatocyte growth factor is a potent mitogen for cultured rabbit renal tubular epithelial cells

1991 ◽  
Vol 174 (2) ◽  
pp. 831-838 ◽  
Author(s):  
Tsukasa Igawa ◽  
Shigeru Kanda ◽  
Hiroshi Kanetake ◽  
Yutaka Saitoh ◽  
Akira Ichihara ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Hepatocyte Growth Factor ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Renal Tubular ◽  
Hepatocyte Growth
Sign in / Sign up

Export Citation Format

Share Document