scholarly journals Systemic dengue infection associated with a new dengue virus type 2 introduction in Brazil – a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Marielton dos Passos Cunha ◽  
Amaro Nunes Duarte-Neto ◽  
Shahab Zaki Pour ◽  
Ludhmila Abrahão Hajjar ◽  
Fernando Pereira Frassetto ◽  
...  
Keyword(s):  
Puerto Rico ◽  
Dengue Virus ◽  
Fatal Case ◽  
Dengue Infection ◽  
Febrile Illness ◽  
Case Presentation ◽  
Wide Range ◽  
Viral Sequencing ◽  
Dengue Type 2 Virus

Abstract Background Dengue infection is caused by an arbovirus with a wide range of presentations, varying from asymptomatic disease to unspecific febrile illness and haemorrhagic syndrome with shock, which can evolve to death. In Brazil, the virus circulates since the 1980s with many introductions of new serotypes, genotypes, and lineages since then. Here we report a fatal case of dengue associated with a Dengue virus (DENV) lineage not detected in the country until now. Case presentation The patient, a 58-year-old man arrived at the hospital complaining of fever and severe abdominal pain due to intense gallbladder edema, mimicking acute abdomen. After 48 h of hospital admission, he evolved to refractory shock and death. DENV RNA was detected in all tissues collected (heart, lung, brain, kidney, spleen, pancreas, liver, and testis). Viral sequencing has shown that the virus belongs to serotype 2, American/Asian genotype, in a new clade, which has never been identified in Brazil before. The virus was phylogenetically related to isolates from central America [Puerto Rico (2005–2007), Martinique (2005), and Guadeloupe (2006)], most likely arriving in Brazil from Puerto Rico. Conclusion In summary, this was the first fatal documented case with systemic dengue infection associated with the new introduction of Dengue type 2 virus in Brazil during the 2019 outbreak.

scholarly journals Complete Genome Sequences of Dengue Virus Type 2 Strains from Kilifi, Kenya

2019 ◽  
Vol 8 (4) ◽  
Author(s):  
Everlyn Kamau ◽  
Charles N. Agoti ◽  
Joyce M. Ngoi ◽  
Zaydah R. de Laurent ◽  
John Gitonga ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Complete Genome ◽  
Sequence Data ◽  
Dengue Infection ◽  
Clinical Samples ◽  
Genome Sequences ◽  
Coastal Kenya ◽  
Dengue Virus Type 2

Dengue infection remains poorly characterized in Africa and little is known regarding its associated viral genetic diversity. Here, we report dengue virus type 2 (DENV-2) sequence data from 10 clinical samples, including 5 complete genome sequences of the cosmopolitan genotype, obtained from febrile adults seeking outpatient care in coastal Kenya.

scholarly journals The detection of anti-dengue virus IgM in urine in participants enrolled in an acute febrile illness study in Puerto Rico

2020 ◽  
Vol 14 (1) ◽  
pp. e0007971
Author(s):  
Elba Caraballo ◽  
B. Katherine Poole-Smith ◽  
Kay M. Tomashek ◽  
Brenda Torres-Velasquez ◽  
Luisa I. Alvarado ◽  
...  
Keyword(s):  
Puerto Rico ◽  
Dengue Virus ◽  
Febrile Illness ◽  
Acute Febrile Illness ◽  
Illness Study

Maiden outbreaks of dengue virus 1 genotype III in rural central India

2014 ◽  
Vol 143 (2) ◽  
pp. 412-418 ◽  
Author(s):  
P. V. BARDE ◽  
B. K. KORI ◽  
M. K. SHUKLA ◽  
P. K. BHARTI ◽  
G. CHAND ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Phylogenetic Analyses ◽  
Dengue Infection ◽  
Central India ◽  
Febrile Illness ◽  
Control Measures ◽  
Serum Samples ◽  
Serological Tests ◽  
Genotype Iii ◽  
Virus Serotype

SUMMARYDengue is regarded as the most important arboviral disease. Although sporadic cases have been reported, serotypes responsible for outbreaks have not been identified from central India over the last 20 years. We investigated two outbreaks of febrile illness, in August and November 2012, from Korea district (Chhattisgarh) and Narsinghpur district (Madhya Pradesh), respectively. Fever and entomological surveys were conducted in the affected regions. Molecular and serological tests were conducted on collected serum samples. Dengue-specific amplicons were sequenced and phylogenetic analyses were performed. In Korea and Narsinghpur districts 37·3% and 59% of cases were positive, respectively, for dengue infection, with adults being the worst affected. RT–PCR confirmed dengue virus serotype 1 genotype III as the aetiology. Ninety-six percent of infections were primary. This is the first time that dengue virus 1 outbreaks have been documented from central India. Introduction of the virus into the population and a conducive mosquitogenic environment favouring increased vector density caused the outbreak. Timely diagnosis and strengthening vector control measures are essential to avoid future outbreaks.

scholarly journals The 1993 dengue 2 epidemic in Charters Towers, North Queensland: clinical features and public health impact

1998 ◽  
Vol 121 (1) ◽  
pp. 151-156 ◽  
Author(s):  
W. J. H. McBRIDE ◽  
H. MULLNER ◽  
J. T. LaBROOY ◽  
I. WRONSKI
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Neutralizing Antibody ◽  
Symptomatic Patient ◽  
Health Impact ◽  
Subclinical Infection ◽  
Dengue Virus Infection ◽  
Dengue Virus Type 2

In 1993 an epidemic caused by dengue virus type 2 occurred in several North Queensland population centres. Charters Towers, estimated population 10000, had 155 officially notified cases. An analysis of symptoms was undertaken using a random sample of 1000 residents to determine specificity of symptoms, the subclinical infection rate, and to establish the true extent of the epidemic. Retrospective diagnoses of dengue fever were based on the presence of both serum dengue 2 neutralizing antibody and presence of symptoms. An estimated 20% of the population had dengue fever. The rate of subclinical infections in this epidemic was 14·6%. There were no symptoms that were specific for dengue fever. Bleeding occurred more frequently in people who recalled a previous dengue infection during a dengue 1 epidemic 12 years earlier (55·6% vs. 16·8%, P=0·003). Surveillance for future epidemics should be based on serological and virological confirmation of dengue virus infection amongst symptomatic patient.

Mice immunized with a dengue type 2 virus E and NS1 fusion protein made in Escherichia coli are protected against lethal dengue virus infection

Vaccine ◽  
1995 ◽  
Vol 13 (13) ◽  
pp. 1251-1258 ◽  
Author(s):  
Ashok Kumar Srivastava ◽  
Joseph Robert Putnak ◽  
Richard Lloyd Warren ◽  
Charles Hearn Hoke
Keyword(s):  
Escherichia Coli ◽  
Virus Infection ◽  
Fusion Protein ◽  
Dengue Virus ◽  
Dengue Virus Infection ◽  
Dengue Type 2 Virus ◽  
Made In

scholarly journals Dengue Virus Infection of Mice: Morphology and Morphogenesis of Dengue Type-2 Virus in Suckling Mouse Neurones

1973 ◽  
Vol 8 (6) ◽  
pp. 1017-1028 ◽  
Author(s):  
Siriporn Sriurairatna ◽  
Natth Bhamarapravati ◽  
Oranuj Phalavadhtana
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Suckling Mouse ◽  
Dengue Virus Infection ◽  
Dengue Type 2 Virus

scholarly journals Frequency and Clinical Manifestations of Dengue in Urban Medellin, Colombia

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Berta Nelly Restrepo ◽  
Mark E. Beatty ◽  
Yenny Goez ◽  
Ruth E. Ramirez ◽  
G. William Letson ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Low Income ◽  
Dengue Infection ◽  
Diagnostic Testing ◽  
Clinical Manifestations ◽  
Febrile Illness ◽  
Hemorrhagic Fever ◽  
Dengue Virus Infection ◽  
Medical Facilities

A dengue fever surveillance study was conducted at three medical facilities located in the low-income district of San Javier in Medellin, Colombia. During March 2008 to 2009, 781 patients with fever regardless of chief complaint were recruited for acute dengue virus infection testing. Of the 781 tested, 73 (9.3%) were positive for dengue infection. Serotypes DENV-2 (77%) and -3 (23%) were detected by PCR. One patient met the diagnostic criteria for dengue hemorrhagic fever. Only 3 out of 73 (4.1%) febrile subjects testing positive for dengue infection were diagnosed with dengue fever by the treating physician. This study confirms dengue virus as an important cause of acute febrile illness in Medellin, Colombia, but it is difficult to diagnose without dengue diagnostic testing.

scholarly journals Endurance, Refuge, and Reemergence of Dengue Virus Type 2, Puerto Rico, 1986–2007

2011 ◽  
Vol 17 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Kate L. McElroy ◽  
Gilberto A. Santiago ◽  
Niall J. Lennon ◽  
Bruce W. Birren ◽  
Matthew R. Henn ◽  
...  
Keyword(s):  
Puerto Rico ◽  
Dengue Virus ◽  
Virus Type ◽  
Dengue Virus Type 2

scholarly journals Trend of Dengue Virus Infection with Seasonal Variation at HIMS, Varanasi, Uttar Pradesh, India

2021 ◽  
Author(s):  
Hari Om Trivedi ◽  
Asim Kumar Singh ◽  
Mukesh Kumar Singh
Keyword(s):  
Platelet Count ◽  
Seasonal Variation ◽  
Dengue Virus ◽  
Dengue Infection ◽  
Uttar Pradesh ◽  
Febrile Illness ◽  
Cerebral Hypoperfusion ◽  
Structural Protein ◽  
Igg Antibody ◽  
Ns1 Antigen

Introduction: Dengue is the most common mosquito borne arboviral infection in India, and it has become endemic in India with consistent episodes. Dengue is an acute febrile illness caused by Dengue Virus (DENV-1, DENV-2, DENV-3, DENV-4), an arthropod of family Flaviviridae, transmitted through the bite of female Aedes aegypti mosquitoes. Although, dengue is more prevalent in humans but also it may sometimes be seen in monkeys. The only animals to be affected when bitten by a mosquito, infected with dengue fever are monkeys other animals do not carry or spread dengue. Patient presents with hyperthermia, headache, severe joint and muscle pain, fatigue and skin rashes. Neurological manifestation in sever dengue results from multiorgan dysfunction due to cerebral edema, haemorrhage due to vascular leak, cerebral hypoperfusion, and electrolyte disturbances. Aim: To study serological markers with association of platelet count and trend of DENV infection with seasonal variation. Materials and Methods: The present retrospective study was conducted for a period of two years in Heritage Institute of Medical Sciences (HIMS), Varanasi, Uttar Pradesh, India, from January 2017 to December 2018. Blood samples were collected for 2140 suspected dengue patients. Out of the serologically positive cases, serological confirmation and platelet count was done for dengue infection. Data was presented as percentages. Results: Total 2140 suspected cases were admitted and out of them 199 (9.3%) were found to be seropositive for dengue infection. Non structural protein 1 (NS1) positive cases out of which total seropositive cases were reported to be 127 (63.81%) and 147 (73.86%) cases were positive for NS1 antigen either alone or along with antibody. Out of the total 199 positive cases thrombocytopenia was observed in 126 (63.31%) cases. Positive cases which were under 15 years of age were reported to be 92 (46.23%). Conclusion: The study concludes that NS1 antigen and IgM- IgG antibody consideration in the diagnosis of dengue infection builds the opportunity of early diagnosis so as to keep away the complications significantly.

scholarly journals Dengue infection in Paracambi, State of Rio de Janeiro, 1990-1995

1997 ◽  
Vol 30 (5) ◽  
pp. 379-383 ◽  
Author(s):  
Rivaldo Venâncio da Cunha ◽  
Renato C. Maspero ◽  
Marize P. Miagostovich ◽  
Eliane S.M. de Araújo ◽  
Daniele da C. Luz ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Aedes Albopictus ◽  
Rio De Janeiro ◽  
Dengue Infection ◽  
Haemagglutination Inhibition ◽  
Older Children ◽  
Dengue Virus Type 2

A seroepidemiological survey was carried out during 1994 in the municipality of Paracambi, state of Rio de Janeiro. Haemagglutination inhibition test positivity was detected in 145 out of 370 (39.2%) schoolchildren. The frequency of positive test by sex was 53.8% (78/145) female and 46.2% (67/145) male. Distribution by age showed the increasing of antibody posivity in older children. Strains of dengue virus type 1 and dengue virus type 2 were isolated before (1990) showing the co-circulation of both serotypes in that area. The house index infestation of Aedes albopictus and Aedes aegypti has been determined.

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