scholarly journals High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53 - NF-kappaB - complex-dependent gene expression in human heart failure

10.1186/gm158 ◽  
2010 ◽  
Vol 2 (6) ◽  
pp. 37 ◽  
Author(s):  
Mun-Kit Choy ◽  
Mehregan Movassagh ◽  
Lee Siggens ◽  
Ana Vujic ◽  
Martin Goddard ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
High Throughput ◽  
Human Heart ◽  
High Throughput Sequencing ◽  
Human Heart Failure ◽  
Associated Factor ◽  
Nf Kappab

scholarly journals Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure

2003 ◽  
Vol 284 (1) ◽  
pp. H268-H276 ◽  
Author(s):  
Charles Steenbergen ◽  
Cynthia A. Afshari ◽  
John G. Petranka ◽  
Jennifer Collins ◽  
Karla Martin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Human Heart ◽  
Compensatory Hypertrophy ◽  
Unknown Etiology ◽  
Inhibitory Protein ◽  
Human Heart Failure ◽  
Altered Gene Expression ◽  
Tnf Α ◽  
Altered Gene

Dilated cardiomyopathy, a disease of unknown etiology and pathogenesis, is associated with heart failure and compensatory hypertrophy. Although cell and animal models suggest a role for altered gene expression in the transition to heart failure, there is a paucity of data derived from the study of human heart tissue. In this study, we used DNA microarray profiling to investigate changes in the expression of genes involved in apoptosis that occur in human idiopathic dilated cardiomyopathic hearts that had progressed to heart failure. We observed altered gene expression consistent with a proapoptotic shift in the TNF-α signaling pathway. Specifically, we found decreased expression of TNF-α- and NF-κB-induced antiapoptotic genes such as growth arrest and DNA damage-inducible ( GADD) 45β, Flice inhibitory protein ( FLIP), and TNF-induced protein 3 ( A20). Consistent with a role for apoptosis in heart failure, we also observed a significant decrease in phosphorylation of BAD at Ser-112. This study identifies several pathways that are altered in human heart failure and provides new targets for therapy.

AT 1 and AT 2 Angiotensin Receptor Gene Expression in Human Heart Failure

Circulation ◽  
1997 ◽  
Vol 95 (5) ◽  
pp. 1201-1206 ◽  
Author(s):  
Guy A. Haywood ◽  
Lars Gullestad ◽  
Tomohiro Katsuya ◽  
Howard G. Hutchinson ◽  
Richard E. Pratt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Human Heart ◽  
Receptor Gene ◽  
Angiotensin Receptor ◽  
Human Heart Failure ◽  
Receptor Gene Expression

scholarly journals Evidence for Coregulation of Myocardial Gene Expression by MEF2 and NFAT in Human Heart Failure

2009 ◽  
Vol 2 (3) ◽  
pp. 212-219 ◽  
Author(s):  
Mary E. Putt ◽  
Sridhar Hannenhalli ◽  
Yun Lu ◽  
Philip Haines ◽  
Hareesh R. Chandrupatla ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Human Heart ◽  
Human Heart Failure ◽  
Myocardial Gene Expression

scholarly journals Sex and Age Dimorphism of Myocardial Gene Expression in Nonischemic Human Heart Failure

2008 ◽  
Vol 1 (2) ◽  
pp. 117-125 ◽  
Author(s):  
David R. Fermin ◽  
Ana Barac ◽  
Sangjin Lee ◽  
Sean P. Polster ◽  
Sridhar Hannenhalli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Human Heart ◽  
Human Heart Failure ◽  
Myocardial Gene Expression

scholarly journals The gene expression fingerprint of human heart failure

2002 ◽  
Vol 99 (17) ◽  
pp. 11387-11392 ◽  
Author(s):  
F.-L. Tan ◽  
C. S. Moravec ◽  
J. Li ◽  
C. Apperson-Hansen ◽  
P. M. McCarthy ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Human Heart ◽  
Human Heart Failure
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