scholarly journals Angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and circulating ACE levels are not associated with outcome in septic critically ill patients

Critical Care ◽  
2011 ◽  
Vol 15 (S1) ◽  
Author(s):  
I Tsangaris ◽  
A Tsantes ◽  
P Kopterides ◽  
G Tsaknis ◽  
G Antonakos ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Converting Enzyme ◽  
Deletion Polymorphism

Angiotensin converting enzyme insertion/deletion genetic polymorphism: Its impact on renal function in critically ill patients*

2008 ◽  
Vol 36 (12) ◽  
pp. 3178-3183 ◽  
Author(s):  
Damien du Cheyron ◽  
Sabine Fradin ◽  
Michel Ramakers ◽  
Nicolas Terzi ◽  
Damien Guillotin ◽  
...  
Keyword(s):  
Renal Function ◽  
Genetic Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Converting Enzyme

Angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and circulating ACE levels are not associated with outcome in critically ill septic patients

2012 ◽  
Vol 50 (2) ◽  
Author(s):  
Argirios Tsantes ◽  
Iraklis Tsangaris ◽  
Petros Kopterides ◽  
Georgios Nikolopoulos ◽  
Eleni Kalamara ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Prognostic Significance ◽  
Serum Levels ◽  
Converting Enzyme ◽  
Ace Polymorphism ◽  
Cardiovascular Failure ◽  
Severity Scores

AbstractIn critically ill patients independent studies have shown contradictory findings regarding the prognostic significance of the D/D genotype of the I/D angiotensin converting enzyme (ACE) polymorphism. The study aim was to evaluate the effect of both ACE I/D polymorphism and ACE serum levels on the clinical outcomes of critically ill septic patients.This study recruited 186 Caucasian patients with sepsis, severe sepsis or septic shock. Epidemiological, clinical data, co-morbidities and severity scores were recorded. Measurements of serum ACE activity and genotyping for ACE I/D polymorphism were carried out. Primary outcomes were the 28- and the 90-day mortality; secondary outcomes included the number of days without renal or cardiovascular failure and ventilation-free days over the 28-day period following study enrolment.Neither 28- nor 90-day mortality were associated with ACE I/D polymorphism (p=0.59 and 0.34, respectively) or circulating ACE levels (p=0.17 and 0.25, respectively). Similarly, ACE polymorphism and levels were not related to ventilation-free days (p=0.14 and 0.25, respectively), days without cardiovascular failure (p=0.14 and 0.81, respectively) and days without renal failure (p=0.64 and 0.27, respectively).Neither ACE I/D polymorphism nor serum ACE levels seem to be significant prognostic factors of clinical outcomes in septic, critically ill patients.

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