scholarly journals Pharmacokinetics of micafungin in patients with severe burn injuries

Critical Care ◽  
2011 ◽  
Vol 15 (S1) ◽  
Author(s):  
J Sasaki ◽  
S Kishino ◽  
S Hori ◽  
N Aikawa
Keyword(s):  
Burn Injuries ◽  
Severe Burn ◽  
Severe Burn Injuries

Effects of Exercise Training on Fat Mass in Individuals with Severe Burn Injuries

2002 ◽  
Vol 23 ◽  
pp. S77
Author(s):  
O. E. Suman ◽  
R. P. Mlcak ◽  
S. J. Thomas ◽  
D. N. Herndon
Keyword(s):  
Exercise Training ◽  
Fat Mass ◽  
Burn Injuries ◽  
Severe Burn ◽  
Severe Burn Injuries

The rise of factor X level in blood plasma of patients at severe burn injuries

2021 ◽  
Author(s):  
George P Kozynets ◽  
Volodymyr P Tsyhankov ◽  
Daria S Korolova ◽  
Olga V Gornytska ◽  
Olexiy M Savchuk ◽  
...  
Keyword(s):  
Protein C ◽  
Antithrombin Iii ◽  
Burn Injury ◽  
Activated Partial Thromboplastin Time ◽  
Burn Injuries ◽  
Factor X ◽  
Severe Burn ◽  
Clotting Factors ◽  
Thrombotic Complications ◽  
Severe Burn Injuries

Abstract This work is dedicated to the detection of imbalance between the pro- and anti-coagulant branches of hemostasis at severe burn injuries by evaluating the content or activity of individual clotting factors. To select the targets for accurate diagnostics we measured the concentrations of soluble fibrin monomeric complexes and fibrinogen, levels of total prothrombin, factor X, protein C and antithrombin III, and recorded the time of clotting in activated partial thromboplastin time and prothrombin time tests. Factor X level was increased in 26 % of patients on the first day after the burn and it rose further in 62 % patients on the 14 th day of recovery. Increasing factor X level is assumed to be a risk factor of thrombotic complications. We propose to use it as a marker of predisposition to thrombosis at severe burn injury.

Endotoxemia and complement activation after severe burn injuries-effects on leukocytes, soluble selectins, and inflammatory cytokines

Inflammation ◽  
1996 ◽  
Vol 20 (3) ◽  
pp. 229-241 ◽  
Author(s):  
O. Ljunghusen ◽  
J. Lundahl ◽  
H. Nettelblad ◽  
B. Nilsson ◽  
F. Sj�gren ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Complement Activation ◽  
Burn Injuries ◽  
Severe Burn ◽  
Severe Burn Injuries

scholarly journals Case report of Wolfe grafting for the management of bilateral cicatricial eyelid ectropion following severe burn injuries

2018 ◽  
Vol 34 ◽  
pp. 58-61 ◽  
Author(s):  
Nina Jovanovic ◽  
Admira Dizdarevic ◽  
Nedzad Dizdarevic ◽  
Amir Haracic ◽  
Lamija Gafurovic
Keyword(s):  
Case Report ◽  
Burn Injuries ◽  
Severe Burn ◽  
Severe Burn Injuries

Expansion potential of skin grafts with novel I-shaped auxetic incisions

2021 ◽  
Author(s):  
Vivek Gupta ◽  
Arnab Chanda
Keyword(s):  
Skin Grafting ◽  
Burn Injuries ◽  
Skin Grafts ◽  
Severe Burn ◽  
Thickness Skin ◽  
Split Thickness Skin Grafting ◽  
Shape Pattern ◽  
Severe Burn Injuries ◽  
Poisson's Ratios ◽  
Poisson’S Ratios

Abstract Severe burn injures lead to millions of fatalities every year due to lack of skin replacements. While skin is a very limited and expensive entity, split thickness skin grafting, which involves the projection of a parallel incision pattern on a small section of healthy excised skin, is typically employed to increase the expansion and cover a larger burn site. To date, the real expansion capacity of such grafts are low (<3 times) and insufficient for treatment of severe burn injuries. In this study, novel I-shaped auxetic incision patterns, which are known to exhibit high negative Poisson’s ratios, have been tested on the skin to investigate their expansion potential. Fourteen two-layer skin graft models with varying incision pattern parameters (i.e., length, spacing, and orientation) were developed using finite element modelling and tested under uniaxial and biaxial tensile loads. The Poisson’s ratio, meshing ratios, and induced stresses were quantified across all models. Graft models tested uniaxially along the orthogonal directions indicated opposite trends in generated Poisson’s ratios, as the length of the I-shape incisions were increased. Biaxially, with a symmetric and closely spaced I-shape pattern, graft meshing ratios up to 15.65 were achieved without overstressing the skin. Overall, the findings from the study indicated that expansion potentials much higher than that of traditional skin grafts can be achieved with novel I-shaped auxetic skin grafts, which would be indispensable for covering large wounds in severe burn injuries.

Severe Burn Injuries Caused by Bioethanol-Design Fireplaces—An Overview on Recreational Fire Threats

2011 ◽  
Vol 32 (2) ◽  
pp. 173-177 ◽  
Author(s):  
Robert Kraemer ◽  
Karsten Knobloch ◽  
Johan Lorenzen ◽  
Karl H. Breuing ◽  
Soeren Koennecker ◽  
...  
Keyword(s):  
Burn Injuries ◽  
Severe Burn ◽  
Severe Burn Injuries

scholarly journals Efficacy and Safety of High Vs Standard Daptomycin Doses Examined in Chinese Patients With Severe Burn Injuries by Pharmacokinetic Evaluation

2020 ◽  
Vol 41 (3) ◽  
pp. 705-713
Author(s):  
Yingzi Huang ◽  
Guozhong Lv ◽  
Linlin Hu ◽  
Yunfu Wu ◽  
Nan Guo ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Burn Injury ◽  
Standard Dose ◽  
Burn Injuries ◽  
Chinese Patients ◽  
High Dose ◽  
Severe Burn ◽  
Serious Adverse Events ◽  
Severe Burn Injuries ◽  
High Doses

Abstract Previous studies and the concentration-dependent antibacterial actions of daptomycin suggested that a high dose would be needed for difficult-to-treat infections in burn patients. Here, we evaluated the effects of administration of low and high doses of daptomycin in patients with severe burn injuries. The study retrospectively analyzed 10 patients with severe burn injuries, using pharmacokinetic (PK) and pharmacodynamic (PD) evaluations of daptomycin doses given to combat serious infections. Daptomycin was administered as a single dose or by multiple doses intravenously at a standard dose of 6 mg/kg/d or a high dose of 12 mg/kg/d for 7 to 14 days. The serum concentrations of daptomycin from patients were analyzed by liquid chromatography–mass spectrometry/mass spectrometry (LC-MS/MS). Burn injury patients treated with high-dose daptomycin had a linear PK profile and a negative correlation between the AUC0–24 and Baux score (R2 = .953 and R2 = .801). The Cmax, AUC0–24, and t(h)½ increased significantly compared with patients given a standard dose. The efficacy of daptomycin against Staphylococcus aureus showed significantly higher rates of (AUC0–24)/MIC and Cmax/MIC after high-dose daptomycin compared with the standard dose, reflected in a significant correlation between a high dose and the Baux score (r = .976, P &lt; .001). Positive S. aureus cultures from two of three high-dose and none of two daptomycin low-dose patients converted from positive to negative after therapy. No serious adverse events or discontinuation of the drug occurred during the treatment period. Daptomycin doses up to 12 mg/kg/d were well tolerated in Chinese patients with severe burn injuries, which were complicated by infections with S. aureus.

Long-term psychosocial adjustment in patients with severe burn injuries: a follow-up study

Burns ◽  
1992 ◽  
Vol 18 (2) ◽  
pp. 121-126 ◽  
Author(s):  
A. Riis ◽  
M. Andersen ◽  
M.B. Pedersen ◽  
K.W. Hall
Keyword(s):  
Psychosocial Adjustment ◽  
Burn Injuries ◽  
Severe Burn ◽  
Follow Up Study ◽  
Severe Burn Injuries
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