scholarly journals The long-term metabolic outcomes of dysglycemia during critical illness

Critical Care ◽  
2010 ◽  
Vol 14 (6) ◽  
pp. 452
Author(s):  
Lavi Oud
Keyword(s):  
Critical Illness ◽  
Metabolic Outcomes

scholarly journals Protein recycling and limb muscle recovery after critical illness in slow- and fast-twitch limb muscle

2019 ◽  
Vol 316 (5) ◽  
pp. R584-R593 ◽  
Author(s):  
Sebastien Preau ◽  
Michael Ambler ◽  
Anna Sigurta ◽  
Anna Kleyman ◽  
Alex Dyson ◽  
...  
Keyword(s):  
Critical Illness ◽  
Functional Disability ◽  
Ex Vivo ◽  
Therapeutic Option ◽  
Limb Muscle ◽  
Fungal Cell ◽  
Hindlimb Muscles ◽  
Initial Reduction ◽  
Male Wistar Rats

An impaired capacity of muscle to regenerate after critical illness results in long-term functional disability. We previously described in a long-term rat peritonitis model that gastrocnemius displays near-normal histology whereas soleus demonstrates a necrotizing phenotype. We thus investigated the link between the necrotizing phenotype of critical illness myopathy and proteasome activity in these two limb muscles. We studied male Wistar rats that underwent an intraperitoneal injection of the fungal cell wall constituent zymosan or n-saline as a sham-treated control. Rats ( n = 74) were killed at 2, 7, and 14 days postintervention with gastrocnemius and soleus muscle removed and studied ex vivo. Zymosan-treated animals displayed an initial reduction of body weight but a persistent decrease in mass of both lower hindlimb muscles. Zymosan increased chymotrypsin- and trypsin-like proteasome activities in gastrocnemius at days 2 and 7 but in soleus at day 2 only. Activated caspases-3 and -9, polyubiquitin proteins, and 14-kDa fragments of myofibrillar actin (proteasome substrates) remained persistently increased from day 2 to day 14 in soleus but not in gastrocnemius. These results suggest that a relative proteasome deficiency in soleus is associated with a necrotizing phenotype during long-term critical illness. Rescuing proteasome clearance may offer a potential therapeutic option to prevent long-term functional disability in critically ill patients.

Long-term recovery In critical illness myopathy is complete, contrary to polyneuropathy

2014 ◽  
Vol 50 (3) ◽  
pp. 431-436 ◽  
Author(s):  
Susanne Koch ◽  
Tobias Wollersheim ◽  
Jeffrey Bierbrauer ◽  
Kurt Haas ◽  
Rudolf Mörgeli ◽  
...  
Keyword(s):  
Critical Illness ◽  
Critical Illness Myopathy

Motoric Subtypes of Delirium and Long-Term Functional and Mental Health Outcomes in Adults After Critical Illness

2021 ◽  
Vol 49 (5) ◽  
pp. e521-e532
Author(s):  
Kimberly F. Rengel ◽  
Christina J. Hayhurst ◽  
James C. Jackson ◽  
Christina S. Boncyk ◽  
Mayur B. Patel ◽  
...  
Keyword(s):  
Mental Health ◽  
Critical Illness ◽  
Health Outcomes ◽  
Mental Health Outcomes

scholarly journals Long-term neuromuscular sequelae of critical illness

2012 ◽  
Vol 260 (1) ◽  
pp. 151-157 ◽  
Author(s):  
Alexander Semmler ◽  
Torsten Okulla ◽  
Markus Kaiser ◽  
Burkhardt Seifert ◽  
Michael T. Heneka
Keyword(s):  
Critical Illness

scholarly journals Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study

2018 ◽  
Vol 6 (3) ◽  
pp. 213-222 ◽  
Author(s):  
Timothy D Girard ◽  
Jennifer L Thompson ◽  
Pratik P Pandharipande ◽  
Nathan E Brummel ◽  
James C Jackson ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cognitive Impairment ◽  
Critical Illness ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Clinical Phenotypes
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