scholarly journals Overexpression of PD-1-related molecules is associated with lymphocyte anergy, mortality, and development of nosocomial infections in septic shock patients

Critical Care ◽  
2010 ◽  
Vol 14 (Suppl 2) ◽  
pp. P22
Author(s):  
C Guignant ◽  
F Venet ◽  
H Kherouf ◽  
A Ayala ◽  
A Lepape ◽  
...  
Keyword(s):  
Septic Shock ◽  
Nosocomial Infections ◽  
Lymphocyte Anergy

Extensively drug-resistant Acinetobacter baumannii nosocomial pneumonia successfully treated with a novel antibiotic combination

2021 ◽  
Author(s):  
Noor Zaidan ◽  
J. Patrik Hornak ◽  
David Reynoso
Keyword(s):  
Septic Shock ◽  
Drug Development ◽  
Acinetobacter Baumannii ◽  
Nosocomial Infections ◽  
Drug Resistant ◽  
Access Protocol ◽  
The Poor ◽  
Extensively Drug Resistant ◽  
Poor Outcomes ◽  
Antibiotic Combination

Extremely drug resistant (XDR) Acinetobacter baumannii cause challenging nosocomial infections. We report the case of a patient with XDR A. baumannii pneumonia and septic shock successfully treated with cefiderocol and a novel antibiotic obtained via expanded access protocol. With focused research and drug development efforts, the poor outcomes associated with these infections may be mitigated.

scholarly journals Increased circulating regulatory T cells (CD4+CD25+CD127−) contribute to lymphocyte anergy in septic shock patients

2008 ◽  
Vol 35 (4) ◽  
pp. 678-686 ◽  
Author(s):  
Fabienne Venet ◽  
Chun-Shiang Chung ◽  
Hakim Kherouf ◽  
Anne Geeraert ◽  
Chistophe Malcus ◽  
...  
Keyword(s):  
Septic Shock ◽  
T Cells ◽  
Regulatory T Cells ◽  
Lymphocyte Anergy

scholarly journals Deciphering heterogeneity of septic shock patients using immune functional assays: a proof of concept study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Chloé Albert Vega ◽  
Guy Oriol ◽  
François Bartolo ◽  
Jonathan Lopez ◽  
Alexandre Pachot ◽  
...  
Keyword(s):  
Septic Shock ◽  
Immune Response ◽  
Nosocomial Infections ◽  
Added Value ◽  
Functional Assay ◽  
Proof Of Concept ◽  
Concept Study ◽  
The Third ◽  
Molecular Features ◽  
Therapeutic Decisions

Abstract The complexity of sepsis pathophysiology hinders patient management and therapeutic decisions. In this proof-of-concept study we characterised the underlying host immune response alterations using a standardised immune functional assay (IFA) in order to stratify a sepsis population. In septic shock patients, ex vivo LPS and SEB stimulations modulated, respectively, 5.3% (1/19) and 57.1% (12/21) of the pathways modulated in healthy volunteers (HV), highlighting deeper alterations induced by LPS than by SEB. SEB-based clustering, identified 3 severity-based groups of septic patients significantly different regarding mHLA-DR expression and TNFα level post-LPS, as well as 28-day mortality, and nosocomial infections. Combining the results from two independent cohorts gathering 20 HV and 60 patients, 1 cluster grouped all HV with 12% of patients. The second cluster grouped 42% of patients and contained all non-survivors. The third cluster grouped 46% of patients, including 78% of those with nosocomial infections. The molecular features of these clusters indicated a distinctive contribution of previously described genes defining a “healthy-immune response” and a “sepsis-related host response”. The third cluster was characterised by potential immune recovery that underlines the possible added value of SEB-based IFA to capture the sepsis immune response and contribute to personalised management.

Persistent high level of circulating midregional-proadrenomedullin and increased risk of nosocomial infections after septic shock

2012 ◽  
Vol 72 (1) ◽  
pp. 293-296 ◽  
Author(s):  
Caroline Guignant ◽  
Nicolas Voirin ◽  
Fabienne Venet ◽  
Alain Lepape ◽  
Guillaume Monneret
Keyword(s):  
Septic Shock ◽  
Nosocomial Infections ◽  
Increased Risk ◽  
High Level

Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock

2010 ◽  
Vol 36 (11) ◽  
pp. 1859-1866 ◽  
Author(s):  
Caroline Landelle ◽  
Alain Lepape ◽  
Nicolas Voirin ◽  
Eve Tognet ◽  
Fabienne Venet ◽  
...  
Keyword(s):  
Septic Shock ◽  
Human Leukocyte Antigen ◽  
Nosocomial Infections ◽  
Human Leukocyte ◽  
Leukocyte Antigen

Nosocomial infections related to fibreoptic intubation

Anaesthesia ◽  
2000 ◽  
Vol 55 (8) ◽  
pp. 816-817 ◽  
Author(s):  
W. R. Garrett ◽  
M. B. Hough
Keyword(s):  
Nosocomial Infections ◽  
Fibreoptic Intubation

Low-Dose Steroids Cut Mortality in Septic Shock

2006 ◽  
Vol 36 (19) ◽  
pp. 24
Author(s):  
BRUCE JANCIN
Keyword(s):  
Septic Shock ◽  
Low Dose

Septic shock patient and ultrasound in the emergency room

2016 ◽  
Vol 37 (S 01) ◽  
Author(s):  
M Algaba Montes ◽  
AÁ Oviedo García ◽  
M Patricio Bordomás
Keyword(s):  
Septic Shock ◽  
Emergency Room ◽  
Septic Shock Patient

Combination of Antibiotic Treatment with the Thrombin Inhibitor Recombinant Hirudin for the Therapy of Experimental Klebsiella pneumoniae Sepsis

1994 ◽  
Vol 71 (06) ◽  
pp. 768-772 ◽  
Author(s):  
Gerhard Dickneite ◽  
Jörg Czech
Keyword(s):  
Septic Shock ◽  
Klebsiella Pneumoniae ◽  
Organ Failure ◽  
Therapeutic Effect ◽  
Disseminated Intravascular Coagulation ◽  
Post Infection ◽  
Thrombin Inhibitor ◽  
Bolus Administration ◽  
Bacterial Burden ◽  
Recombinant Hirudin

SummaryRats which were infected with the gramnegative pathogen Klebsiella pneumoniae develop disseminated intravascular coagulation (DIC), multi-organ failure (MOF) and finally die in a septic shock. We investigated the therapeutic effect of antibiotic (tobramycin) treatment combined with the infusion of the highly specific thrombin inhibitor rec. hirudin. Although administration of 2 mg/kg tobramycin alone leads to a decrease of the bacterial burden, DIC could not be prevented. Infusion of rec. hirudin (0.25 mg/kg x h) for 4 h (start of treatment 1 h post infection), in addition to a bolus administration of tobramycin, led to an amelioration of DIC parameters as fibrinogen, thrombin-antithrombin complex (TAT) and platelets. Serum transaminase levels (GOT, GPT) as a marker of MOF were significantly improved by rec. hirudin, the T50 value increased from 17 h in the tobramycin group to 42 h in the tobramycin + rec. hirudin giuup, muilality rates were 90% or 60%, respectively. Combination of heparin (10011/kg x h) and tobramycin was not effective on survival.

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