scholarly journals A fast and accurate diagnostic test for severe sepsis using model-based insulin sensitivity and clinical data

Critical Care ◽  
2010 ◽  
Vol 14 (Suppl 2) ◽  
pp. P13
Author(s):  
JD Parente ◽  
D Lee ◽  
J Lin ◽  
JG Chase ◽  
GM Shaw
Keyword(s):  
Severe Sepsis ◽  
Insulin Sensitivity ◽  
Diagnostic Test ◽  
Clinical Data ◽  
Model Based

scholarly journals Model-Based Insulin Sensitivity as a New Biomarker of Sepsis Diagnosis in the Intensive Care Unit

2021 ◽  
Vol 20 (2) ◽  
Author(s):  
Wan Fadzlina Wan Muhd Shukeri ◽  
Mohd Basri Mat-Nor ◽  
Azrina Md. Ralib ◽  
Ummu Kulthum Jamaludin
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Insulin Sensitivity ◽  
Real Time ◽  
Diagnostic Test ◽  
Characteristic Curve ◽  
Diagnostic Value ◽  
Diabetic Patients ◽  
Separate Analysis ◽  
Model Based

INTRODUCTION: Currently, there is a lack of real-time biomarker to diagnose sepsis. Insulin sensitivity (SI) may be determined in real-time using mathematical glucose-insulin models, but its effectiveness as a diagnostic test of sepsis remains unexplored. We aimed to explore the diagnostic value of model-based SI as a new biomarker of sepsis in a mixed cohort of diabetic and non-diabetic patients newly admitted to the intensive care unit (ICU). MATERIALS AND METHODS: In this cross-sectional study, we analysed SI levels derived from the Intensive[1]Control-of-Insulin-Nutrition-Glucose model in septic (n=45) and non-septic (n = 41) patients upon their ICU admission. The diagnostic value of model-based SI for sepsis was determined through analysis of the area under the curve (AUC) of the receiver operating characteristic curve. RESULTS: Baseline SI levels were significantly lower in patients with sepsis than those without sepsis (0.560 (SD=0.676) vs. 1.097 (SD=1.473) x 10-4 L/mU/min, P = 0.037). However, the AUC of 0.588 revealed that model-based SI was a poor diagnostic test of sepsis in the mixed cohort of diabetics and non-diabetics. In a separate analysis among the non-diabetics (n=19), model-based SI predicted sepsis with clinically valid performance (AUC 0.911). CONCLUSION: Presence of sepsis significantly reduced SI in the critically ill patients but a low SI could predict sepsis only in the non-diabetic cohort.

scholarly journals Insulin sensitivity and sepsis score: A correlation between model-based metric and sepsis scoring system in critically ill patients

2017 ◽  
Vol 32 ◽  
pp. 112-123
Author(s):  
Fatanah M. Suhaimi ◽  
J. Geoffrey Chase ◽  
Christopher G. Pretty ◽  
Geoffrey M. Shaw ◽  
Normy N. Razak ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Scoring System ◽  
Model Based ◽  
Sepsis Score

scholarly journals A Prospective, Randomized Pilot Trial of Model-Based Warfarin Dose Initiation using CYP2C9 Genotype and Clinical Data

2005 ◽  
Vol 3 (3) ◽  
pp. 137-145 ◽  
Author(s):  
M. A. Hillman ◽  
R. A. Wilke ◽  
S. H. Yale ◽  
H. J. Vidaillet ◽  
M. D. Caldwell ◽  
...  
Keyword(s):  
Clinical Data ◽  
Pilot Trial ◽  
Warfarin Dose ◽  
Cyp2c9 Genotype ◽  
Model Based

scholarly journals Changes in Identified, Model-based Insulin Sensitivity can be used to Improve Risk and Variability Forecasting in Glycaemic Control

2018 ◽  
Vol 51 (15) ◽  
pp. 311-316 ◽  
Author(s):  
Vincent Uyttendaele ◽  
Jennifer L. Dickson ◽  
Sophie Morton ◽  
Geoffrey Shaw ◽  
Thomas Desaive ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Glycaemic Control ◽  
Model Based

scholarly journals Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis

2015 ◽  
Vol 48 (20) ◽  
pp. 372-376 ◽  
Author(s):  
Fatanah M. Suhaimi ◽  
J. Geoffrey Chase ◽  
Christopher G. Pretty ◽  
Geoffrey M. Shaw ◽  
Normy Razak ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Sepsis Diagnosis ◽  
Model Based

Validation of the Prostate Tumorlet Model Based on Multi-Institution Clinical Data

Brachytherapy ◽  
2014 ◽  
Vol 13 ◽  
pp. S69-S70
Author(s):  
Dorin Todor ◽  
Mitchell S. Anscher ◽  
Michael P. Hagan ◽  
Sebastian Kaden ◽  
Frank-Andre Siebert
Keyword(s):  
Clinical Data ◽  
Model Based

scholarly journals Observation of changes in model-based insulin sensitivity during haemodialysis transitions for critically ill patients

2012 ◽  
Vol 45 (18) ◽  
pp. 349-354
Author(s):  
Ummu K. Jamaludin ◽  
Paul D. Docherty ◽  
J. Geoffrey Chase ◽  
Aaron Le Compte ◽  
Geoffrey M. Shaw
Keyword(s):  
Insulin Sensitivity ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Model Based

Variability of Model based Insulin Sensitivity in Liver Transplanted Patients

2014 ◽  
Vol 47 (3) ◽  
pp. 11595-11598
Author(s):  
J Homlok ◽  
J G Chase ◽  
B Benyó
Keyword(s):  
Insulin Sensitivity ◽  
Model Based
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