scholarly journals Clinical effects of polymyxin B immobilised fiber with direct hemoperfusion for the patients of severe sepsis or septic shock caused by intra-abdominal infections

Critical Care ◽  
2009 ◽  
Vol 13 (Suppl 1) ◽  
pp. P283
Author(s):  
T Ikeda ◽  
K Ikeda ◽  
H Taniuchi ◽  
S Suda ◽  
Y Takahashi
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Polymyxin B ◽  
Clinical Effects ◽  
Direct Hemoperfusion ◽  
Abdominal Infections

Clinical Effects of Direct Hemoperfusion Using a Polymyxin-B Immobilized Column in Solid Organ Transplanted Patients with Signs of Severe Sepsis and Septic Shock. a Pilot Study

2007 ◽  
Vol 30 (10) ◽  
pp. 915-922 ◽  
Author(s):  
F. Ruberto ◽  
F. Pugliese ◽  
A. D'alio ◽  
S. Martelli ◽  
K. Bruno ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Lipid A ◽  
Polymyxin B ◽  
Consensus Conference ◽  
Solid Organ ◽  
Clinical Effects ◽  
Direct Hemoperfusion ◽  
Respiratory Parameters ◽  
Sepsis And Septic Shock

Background Polymyxin B (PMX-B) is a polycationic antibiotic, known to bind the lipid A portion of endotoxin, a cell wall component found exclusively in gram negative bacteria (GNB). An extracorporeal hemoperfusion device (TORAYMYXIN) has been developed: PMX is covalently bound on the surface of an insoluble carrier material so that the endotoxin can be inactivated in the blood without exerting its toxicity on the brain and kidney The aim of this study was to clarify the efficacy, safety and clinical effects of direct hemoperfusion with an immobilized polymyxin-B fiber column (DHP-PMX) in solid organ transplanted patients with severe sepsis or septic shock. Methods From June 2004 to May 2005, 15 patients (10 men and 5 women), mean age 55 years old (46–65 range), underwent kidney or liver transplantation and developed severe sepsis or septic shock, as defined by the Consensus Conference of American College Physicians/Society of Critical Care Medicine (ACCP/SCCM) criteria. GNB were detected in all the patients receiving conventional treatments including antibiotic therapy, vasopressive or inotropic agents, and ventilation support. The DHP-PMX treatment was performed three times in each patient. Hemodynamic and respiratory parameters, dosage of vasopressor/inotropic drugs were assessed at baseline and after each treatment. Results No adverse events occurred. From baseline to 3rd treatment, mean arterial pressure (MAP) was increased (from 63±5 to 83±4 mmHg), while the dosage of dobutamine (from 7.5±3 to 3±2 mcg/kg/min) and noradrenaline (from 1.3±0.45 to 0.05±0.02 mcg/kg/min) were reduced. The PaO2/FiO2 ratio increased (from 234±38.47 to 290±107.48 mmHg). Conclusion The use of DHP-PMX in association with conventional therapy may be an important aid in patients with sepsis.

Clinical Effects of a Longer Duration of Polymyxin B-Immobilized Fiber Column Direct Hemoperfusion Therapy for Severe Sepsis and Septic Shock

2015 ◽  
Vol 19 (4) ◽  
pp. 316-323 ◽  
Author(s):  
Chizuru Yamashita ◽  
Yoshitaka Hara ◽  
Naohide Kuriyama ◽  
Tomoyuki Nakamura ◽  
Osamu Nishida
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Polymyxin B ◽  
Clinical Effects ◽  
Direct Hemoperfusion ◽  
Sepsis And Septic Shock

Clinical Effects and Outcomes After Polymyxin B–Immobilized Fiber Column Direct Hemoperfusion Treatment for Septic Shock in Preterm Neonates*

2020 ◽  
Vol 21 (2) ◽  
pp. 156-163 ◽  
Author(s):  
Naoto Nishizaki ◽  
Taichi Hara ◽  
Kaoru Obinata ◽  
Mayu Nakagawa ◽  
Toshiaki Shimizu
Keyword(s):  
Septic Shock ◽  
Polymyxin B ◽  
Preterm Neonates ◽  
Clinical Effects ◽  
Direct Hemoperfusion

Clinical Effects of Use Polymyxin B Fixed on Fibers in Liver Transplant Patients With Severe Sepsis or Septic Shock

2007 ◽  
Vol 39 (6) ◽  
pp. 1953-1955 ◽  
Author(s):  
F. Ruberto ◽  
F. Pugliese ◽  
A. D’Alio ◽  
S. Martelli ◽  
K. Bruno ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Liver Transplant ◽  
Polymyxin B ◽  
Clinical Effects ◽  
Transplant Patients
Sign in / Sign up

Export Citation Format

Share Document