scholarly journals Use of tissue oxygenation saturation in association with skin temperature as an indicator of the peripheral tissue perfusion in critically ill patients

Critical Care ◽  
2009 ◽  
Vol 13 (Suppl 1) ◽  
pp. P236
Author(s):  
A Lima ◽  
C Ince ◽  
J Bakker
Keyword(s):  
Skin Temperature ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Tissue Oxygenation ◽  
Tissue Perfusion ◽  
Peripheral Tissue

PRELIMINARY USE OF NONINVASIVE, NIRS-MEASURED TISSUE PERFUSION IN CRITICALLY ILL PATIENTS.

2005 ◽  
Vol 33 ◽  
pp. A126
Author(s):  
Jacqueline Wu ◽  
Olusola Soyemi ◽  
Matthias Walz ◽  
Ye Yang ◽  
Babs Soller ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Tissue Perfusion

scholarly journals Study protocol and pilot results of an observational cohort study evaluating effect of red blood cell transfusion on oxygenation and mitochondrial oxygen tension in critically ill patients with anaemia: the INsufficient Oxygenation in the Intensive Care Unit (INOX ICU-2) study

BMJ Open ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. e036351 ◽  
Author(s):  
Meryem Baysan ◽  
Mendi S Arbous ◽  
Egbert G Mik ◽  
Nicole P Juffermans ◽  
Johanna G van der Bom
Keyword(s):  
Intensive Care ◽  
Blood Cell ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Critically Ill Patients ◽  
Tissue Oxygenation ◽  
Protoporphyrin Ix ◽  
Oxygen Balance ◽  
Mixed Effect ◽  
Rbc Transfusion

IntroductionThe recently developed protoporphyrin IX-triple state lifetime technique measures mitochondrial oxygenation tension (mitoPO2) in vivo at the bedside. MitoPO2might be an early indicator of oxygen disbalance in cells of critically ill patients and therefore may support clinical decisions regarding red blood cell (RBC) transfusion. We aim to investigate the effect of RBC transfusion and the associated changes in haemoglobin concentration on mitoPO2 and other physiological measures of tissue oxygenation and oxygen balance in critically ill patients with anaemia. We present the protocol and pilot results for this study.Methods and analysisWe perform a prospective multicentre observational study in three mixed intensive care units in the Netherlands with critically ill patients with anaemia in whom an RBC transfusion is planned. The skin of the anterior chest wall of the patients is primed with a 5-aminolevulinic acid patch for 4 hours for induction of mitochondrial protoporphyrin-IX to enable measurements of mitoPO2, which is done with the COMET monitoring device. At multiple predefined moments, before and after RBC transfusion, we assess mitoPO2 and other physiological parameters of oxygen balance and tissue oxygenation. Descriptive statistics will be used to describe the data. A linear mixed-effect model will be used to study the association between RBC transfusion and mitoPO2 and other traditional parameters of oxygenation, oxygen delivery and oxygen balance. Missing data will be imputed using multiple imputation methods.Ethics and disseminationThe institutional ethics committee of each participating centre approved the study (reference P16.303), which will be conducted according to the 1964 Helsinki declaration and its later amendments. The results will be submitted for publication in peer-reviewed journals and presented at scientific conferences.Trial registration numberNCT03092297.

Monitoring Tissue Perfusion, Oxygenation, and Metabolism in Critically Ill Patients

CHEST Journal ◽  
2013 ◽  
Vol 143 (6) ◽  
pp. 1799-1808 ◽  
Author(s):  
Nasirul J. Ekbal ◽  
Alex Dyson ◽  
Claire Black ◽  
Mervyn Singer
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Tissue Perfusion
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