scholarly journals Serine/threonine kinase-protein kinase B and extracellular signal-regulated kinase regulate ventilator-induced pulmonary fibrosis after bleomycin-induced acute lung injury: a prospective, controlled animal experiment

Critical Care ◽  
2008 ◽  
Vol 12 (4) ◽  
pp. R103 ◽  
Author(s):  
Li-Fu Li ◽  
Shuen-Kuei Liao ◽  
Chung-Chi Huang ◽  
Ming-Jui Hung ◽  
Deborah A Quinn
Keyword(s):  
Acute Lung Injury ◽  
Protein Kinase ◽  
Pulmonary Fibrosis ◽  
Lung Injury ◽  
Animal Experiment ◽  
Protein Kinase B ◽  
Serine Threonine Kinase ◽  
Threonine Kinase ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

scholarly journals Antimelanogenic Effects of Polygonum tinctorium Flower Extract from Traditional Jeju Fermentation via Upregulation of Extracellular Signal-Regulated Kinase and Protein Kinase B Activation

2018 ◽  
Vol 19 (10) ◽  
pp. 2895 ◽  
Author(s):  
You Chung ◽  
Ji-Hye Ko ◽  
Hyun-Kyu Kang ◽  
Seoyeon Kim ◽  
Choon Kang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
High Performance ◽  
Protein Kinase B ◽  
Skin Irritation ◽  
Akt Inhibitor ◽  
Western Blot Assay ◽  
Extracellular Signal Regulated Kinase ◽  
Flower Extract ◽  
Extracellular Signal ◽  
Polygonum Tinctorium

This study was carried out to investigate the antimelanogenic effects of a Polygonum tinctorium flower extract obtained using red nuruk, a traditional Jeju barley-based fermentation starter. We also studied the mechanism of action of the P. tinctorium fermented flower extract (PTFFE) in mouse melanoma cells (B16F10). Cells were treated with various concentrations (62.5, 125 and 250 μg/mL) of PTFFE and the results showed that PTFFE significantly decreased the melanin content and tyrosinase activity without being cytotoxic. In addition, PTFFE strongly inhibited the expression of tyrosinase and tyrosinase-related protein 2 by decreasing the expression of the microphthalmia-associated transcription factor, as shown by a western blot assay. Furthermore, PTFFE inhibited melanogenesis via upregulation of the phosphorylation of extracellular signal-regulated kinase (ERK) and protein kinase B, also known as AKT. We also used inhibitors such as PD98059 (a specific ERK inhibitor) or LY294002 (an AKT inhibitor) to determine whether the signaling pathways are involved. High-performance liquid chromatography fingerprinting showed the presence of a quercetin glucoside (isoquercitrin) and quercetin in PTFFE. To test the potential for PTFFE application as a cosmetic material, we also performed a primary skin irritation test on human skin. In this assay, PTFFE did not induce any adverse reactions at the treatment dose. Based on these results, we suggest that PTFFE may be considered a potential antimelanogenesis candidate for topical applications.

scholarly journals Hinokitiol reduces tumor metastasis by inhibiting heparanase via extracellular signal-regulated kinase and protein kinase B pathway

2020 ◽  
Vol 17 (3) ◽  
pp. 403-413
Author(s):  
Yueh-Jung Wu ◽  
Wei-Jie Hsu ◽  
Li-Hsien Wu ◽  
Huei-Pu Liou ◽  
Christian Ronquillo Pangilinan ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Tumor Metastasis ◽  
Protein Kinase B ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal
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