scholarly journals Risk factors associated with delirium in a general ICU: role of S-100 protein

Critical Care ◽  
2008 ◽  
Vol 12 (Suppl 2) ◽  
pp. P513
Author(s):  
A Rubino ◽  
F Forfori ◽  
G Licitra ◽  
P Cosimini ◽  
F Foltran ◽  
...  
Keyword(s):  
Risk Factors ◽  
Factors Associated ◽  
S 100

scholarly journals Role of β-Adrenergic Receptors and Nitric Oxide Signaling in Exercise-Mediated Cardioprotection

Physiology ◽  
2013 ◽  
Vol 28 (4) ◽  
pp. 216-224 ◽  
Author(s):  
John W. Calvert ◽  
David J. Lefer
Keyword(s):  
Nitric Oxide ◽  
Risk Factors ◽  
Adrenergic Receptors ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Nitric Oxide Signaling ◽  
Factors Associated ◽  
Cardioprotective Effects ◽  
Β Adrenergic Receptors

Exercise promotes cardioprotection in both humans and animals not only by reducing risk factors associated with cardiovascular disease but by reducing myocardial infarction and improving survival following ischemia. This article will define the role that nitric oxide and β-adrenergic receptors play in mediating the cardioprotective effects of exercise in the setting of ischemia-reperfusion injury.

scholarly journals ROLE OF VARIOUS RISK FACTORS ASSOCIATED WITH CARDIOVASCULAR DISEASES

2013 ◽  
Vol 4 (5) ◽  
pp. 44-50
Author(s):  
Pranay Wal ◽  
Ankita Wal ◽  
Nikita Saraswat ◽  
Shalini Singh ◽  
Shikha Bajpai
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Factors Associated

Risk factors associated with sensitive skin and potential role of lifestyle habits: a cross-sectional study

2017 ◽  
Vol 42 (6) ◽  
pp. 656-658 ◽  
Author(s):  
D. Falcone ◽  
R. J. H. Richters ◽  
N. E. Uzunbajakava ◽  
P. E. J. van Erp ◽  
P. C. M. van de Kerkhof
Keyword(s):  
Risk Factors ◽  
Potential Role ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Sensitive Skin ◽  
Lifestyle Habits ◽  
Cross Sectional ◽  
Factors Associated

scholarly journals Overexpressing PLA2G6 mutations cause symptoms of young–onset dystonia–parkinsonism type 14 and reduction in DHA levels in zebrafish model

2020 ◽  
Author(s):  
Tu-Hsueh Yeh ◽  
Han-Fang Liu ◽  
Mei-Ling Cheng ◽  
Yin-Cheng Huang ◽  
Ying-Zu Huang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dopaminergic Neurons ◽  
Molecular Mechanisms ◽  
Motor Disorder ◽  
Loss Of Function ◽  
Phospholipase Activity ◽  
Young Onset ◽  
Factors Associated ◽  
Metabolomics Analysis

Abstract Background: Parkinson’s disease (PD) is the most common neurodegenerative motor disorder, which is currently incurable. Mutations in many genes have been demonstrated to be the primary risk factors associated with the familial or idiopathic PD; however, the mechanisms underlying these genetic mutations resulting in parkinsonism remains unclear. Phospholipase A2 group VI (PLA2G6) has been shown to regulate lipid metabolism and homeostasis in the nervous system. Previous studies have shown that point mutations in PLA2G6 might be the risk factors associated with the young–onset of dystonia–parkinsonism type 14 (PARK14). However, limited information is available regarding its pathogenic role and the mechanism underlying its function. Methods: To study the role of PLA2G6 mutations in zebrafish PARK14 models, we injected different mutation constructs of human PLA2G6 genes and zebrafish pla2g6 deletion constructs in the zebrafish larvae. We analyzed the locomotion behavior, performed immunohistochemistry to examine the formation of dopaminergic neurons, and identified the defective metabolites affected by PLA2G6 mutations through metabolomics analysis. Results: Injection of human PLA2G6 mutations and zebrafish pla2g6 deletion constructs induced symptoms such as motility defects and reduced number of dopaminergic neurons, and these symptoms resembled those observed in PARK14. These phenotypes could be rescued by treatment with L-dopa. Furthermore, the injection of two PLA2G6 mutation constructs, D331Y and T572I, led to a decrease in the phospholipase activity of PLA2G6 and its lipid metabolites, indicating that these two mutations are the loss-of-function mutations. We further performed metabolomics analysis to identify which lipids are majorly affected by the overexpression of PLA2G6 and PLA2G6 mutants. We found that injecting D331Y or T572I mutation constructs led to higher phospholipid and lower DHA levels. Conclusions: D331Y and T572I injections in zebrafish were sufficient to create a PD phenotypes. In addition, D331Y and T572I are loss of function mutations and cause defective phospholipase activity and reduced the level of DHA. These results have helped us elucidate the role of PLA2G6 mutations in PARK14 and further led to a deeper understanding of the molecular mechanisms underlying PD. The results of this study may also facilitate the development of therapeutic strategies for PD.

scholarly journals Artificial Intelligence and Hypertension: Recent Advances and Future Outlook

2020 ◽  
Vol 33 (11) ◽  
pp. 967-974
Author(s):  
Thanat Chaikijurajai ◽  
Luke J Laffin ◽  
Wai Hong Wilson Tang
Keyword(s):  
Artificial Intelligence ◽  
Risk Factors ◽  
Big Data ◽  
Public Health Problem ◽  
Patient Specific ◽  
Medication Regimen ◽  
Factors Associated ◽  
Promising Tool ◽  
Prevention And Treatment

Abstract Prevention and treatment of hypertension (HTN) are a challenging public health problem. Recent evidence suggests that artificial intelligence (AI) has potential to be a promising tool for reducing the global burden of HTN, and furthering precision medicine related to cardiovascular (CV) diseases including HTN. Since AI can stimulate human thought processes and learning with complex algorithms and advanced computational power, AI can be applied to multimodal and big data, including genetics, epigenetics, proteomics, metabolomics, CV imaging, socioeconomic, behavioral, and environmental factors. AI demonstrates the ability to identify risk factors and phenotypes of HTN, predict the risk of incident HTN, diagnose HTN, estimate blood pressure (BP), develop novel cuffless methods for BP measurement, and comprehensively identify factors associated with treatment adherence and success. Moreover, AI has also been used to analyze data from major randomized controlled trials exploring different BP targets to uncover previously undescribed factors associated with CV outcomes. Therefore, AI-integrated HTN care has the potential to transform clinical practice by incorporating personalized prevention and treatment approaches, such as determining optimal and patient-specific BP goals, identifying the most effective antihypertensive medication regimen for an individual, and developing interventions targeting modifiable risk factors. Although the role of AI in HTN has been increasingly recognized over the past decade, it remains in its infancy, and future studies with big data analysis and N-of-1 study design are needed to further demonstrate the applicability of AI in HTN prevention and treatment.

USSR: creation and collapse of the empire in the context of «risk society»

2020 ◽  
Vol 7 (1) ◽  
pp. 51-58
Author(s):  
Andrey Yu. Mordovcev ◽  
Aleksey Yu. Mamychev ◽  
Tatayna V. Mordovceva
Keyword(s):  
Risk Factors ◽  
Risk Society ◽  
Legal Systems ◽  
Legal Policy ◽  
Factors Associated ◽  
Legal Identity ◽  
Legal Space ◽  
State Actors

The article identifies and analyzes the risk factors associated with the formation and collapse of the USSR as a recreation of the Imperial political and legal space, a type of national and supranational socio-political and legal identity. The authors consider the various processes of integration and disintegration of state actors in the context of the risk society paradigm, recognizing its methodological foundations. Both the emergence and collapse of the USSR are responses to the escalating risks and crises of the Russian political and legal systems, and a way out. When considering such problems, it is impossible to eliminate mental and cultural archetypes, historic state and legal experience, and the place and role of personality in history, especially within the nations contradictory history. In this regard, the article analyzes the positions of leadership of the RSFSR and the Ukrainian SSR in the matter of national legal policy that influenced the collapse of the USSR.

Risk factors associated with live fire training: Buildup of heat stress and fatigue, recovery and role of micro-breaks

2013 ◽  
Vol 11 (2,3) ◽  
pp. 109-121 ◽  
Author(s):  
Ashutosh Mani ◽  
Kristin Musolin ◽  
Kelley James ◽  
Georganne Kincer ◽  
Barbara Alexander ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heat Stress ◽  
Factors Associated ◽  
Fatigue Recovery

Elucidating The Genetic Factors Contributing Towards Susceptibility And Severity Of Covid 19

2021 ◽  
Vol 01 ◽  
Author(s):  
Syeda Marriam Bakhtiar ◽  
Syeda Eeman Zahra Bokhari ◽  
Iqra Riasat ◽  
Erum Dilshad
Keyword(s):  
Risk Factors ◽  
Chronic Disease ◽  
Genetic Factors ◽  
Potential Role ◽  
Viral Transmission ◽  
Modifiable Risk Factors ◽  
Animal Host ◽  
Factors Associated ◽  
Human Source

: COVID-19 or SARS-CoV-2 or 2019-nCov is a pandemic disease that occurred in December 2019 from Wuhan, Hubei Province of China. It was first transmitted from the animal host to a human source, after which it followed human-human transmission and spread exponentially worldwide. Various countries have fallen prey to this virus, but there are certain countries or populations, which have been more affected by this than others. Moreover, the demographics of transmission and affected individuals are also variable from country-country. The purpose of this article is to highlight the non-modifiable risk factors for COVID-19 and their analysis in various populations affecting their susceptibility. Besides age, gender, and blood group, two major genetic factors associated with this disease are discussed here including the potential of IL-6, in causing chronic disease conditions and the rs1800795 G/C-174 IL-6 polymorphism in the IL-6 gene and with the potential role of ACE-2 receptor in viral transmission and pathogenicity with its protective and disease-causing variants.

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