scholarly journals Effects of inhaled iloprost on right ventriculovascular coupling and ventricular interdependence in acute pulmonary hypertension

Critical Care ◽  
2008 ◽  
Vol 12 (Suppl 2) ◽  
pp. P261
Author(s):  
S Rex ◽  
C Missant ◽  
P Claus ◽  
W Buhre ◽  
R Rossaint ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Ventricular Interdependence ◽  
Inhaled Iloprost ◽  
Acute Pulmonary Hypertension

Effects of inhaled iloprost in acute pulmonary hypertension: Mechanisms beyond pure vasodilation

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
S Rex ◽  
C Missant ◽  
P Claus ◽  
R Autschbach ◽  
R Rossaint ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Inhaled Iloprost ◽  
Acute Pulmonary Hypertension

Acute Improved Hemodynamics following Inhaled Iloprost in Chronic Thromboembolic Pulmonary Hypertension

Respiration ◽  
2008 ◽  
Vol 76 (2) ◽  
pp. 154-159 ◽  
Author(s):  
Sabine Krug ◽  
Stefan Hammerschmidt ◽  
Hans Pankau ◽  
Hubert Wirtz ◽  
Hans-Jürgen Seyfarth
Keyword(s):  
Pulmonary Hypertension ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Inhaled Iloprost ◽  
Thromboembolic Pulmonary Hypertension

Combination Therapy with Oral Sildenafil and Inhaled Iloprost for Severe Pulmonary Hypertension

2002 ◽  
Vol 136 (7) ◽  
pp. 515 ◽  
Author(s):  
Hossein Ardeschir Ghofrani ◽  
Ralph Wiedemann ◽  
Frank Rose ◽  
Horst Olschewski ◽  
Ralph Theo Schermuly ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Combination Therapy ◽  
Severe Pulmonary Hypertension ◽  
Inhaled Iloprost

Pulmonary vasodilation by nitric oxide gas and prodrug aerosols in acute pulmonary hypertension

1998 ◽  
Vol 84 (2) ◽  
pp. 435-441 ◽  
Author(s):  
Christophe Adrie ◽  
Fumito Ichinose ◽  
Alexandra Holzmann ◽  
Larry Keefer ◽  
William E. Hurford ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Vascular Resistance ◽  
Pulmonary Circulation ◽  
Half Life ◽  
Hemodynamic Effects ◽  
Pulmonary Vasodilation ◽  
Short Half Life ◽  
Acute Pulmonary Hypertension ◽  
Inhaled No

Adrie, Christophe, Fumito Ichinose, Alexandra Holzmann, Larry Keefer, William E. Hurford, and Warren M. Zapol. Pulmonary vasodilation by nitric oxide gas and prodrug aerosols in acute pulmonary hypertension. J. Appl. Physiol. 84(2): 435–441, 1998.—Sodium 1-( N, N-diethylamino)diazen-1-ium-1,2-diolate {DEA/NO; Et2N[N(O)NO]Na} is a compound that spontaneously generates nitric oxide (NO). Because of its short half-life (2.1 min), we hypothesized that inhaling DEA/NO aerosol would selectively dilate the pulmonary circulation without decreasing systemic arterial pressure. We compared the pulmonary selectivity of this new NO donor with two other reference drugs: inhaled NO and inhaled sodium nitroprusside (SNP). In seven awake sheep with pulmonary hypertension induced by the infusion of U-46619, we compared the hemodynamic effects of DEA/NO with those of incremental doses of inhaled NO gas. In seven additional awake sheep, we examined the hemodynamic effects of incremental doses of inhaled nitroprusside (i.e., SNP). Inhaled NO gas selectively dilated the pulmonary vasculature. Inhaled DEA/NO produced nonselective vasodilation; both systemic vascular resistance (SVR) and pulmonary vascular resistance (PVR) were reduced. Inhaled SNP selectively dilated the pulmonary circulation at low concentrations (≤10−2 M), inducing a decrease of PVR of up to 42% without any significant decrease of SVR (−5%), but nonselectively dilated the systemic circulation at larger doses (>10−2 M). In conclusion, despite its short half-life, DEA/NO is not a selective pulmonary vasodilator compared with inhaled NO. Inhaled SNP appears to be selective to the pulmonary circulation at low doses but not at higher levels.

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