scholarly journals Evaluation of the implementation of a fully automated algorithm (eMPC) in an interacting infusion pump system for the establishment of tight glycaemic control in medical ICU patients

Critical Care ◽  
2008 ◽  
Vol 12 (Suppl 2) ◽  
pp. P156
Author(s):  
J Plank ◽  
R Kulnik ◽  
C Pachler ◽  
R Hovorka ◽  
D Röthlein ◽  
...  
Keyword(s):  
Glycaemic Control ◽  
Infusion Pump ◽  
Tight Glycaemic Control ◽  
Pump System ◽  
Icu Patients ◽  
Automated Algorithm

Tight glycaemic control by an automated algorithm with time-variant sampling in medical ICU patients

2008 ◽  
Vol 34 (7) ◽  
pp. 1224-1230 ◽  
Author(s):  
Christoph Pachler ◽  
Johannes Plank ◽  
Heinz Weinhandl ◽  
Ludovic J. Chassin ◽  
Malgorzata E. Wilinska ◽  
...  
Keyword(s):  
Glycaemic Control ◽  
Tight Glycaemic Control ◽  
Icu Patients ◽  
Automated Algorithm

scholarly journals Robust Tight Glycaemic Control of ICU patients

2011 ◽  
Vol 44 (1) ◽  
pp. 4995-5000
Author(s):  
Levente Kovács ◽  
Péter Szalay ◽  
Balázs Benyó ◽  
J. Geoffrey Chase
Keyword(s):  
Glycaemic Control ◽  
Tight Glycaemic Control ◽  
Icu Patients

Tight glycaemic control: clinical implementation of protocols

2009 ◽  
Vol 23 (4) ◽  
pp. 461-472 ◽  
Author(s):  
Frank Nobels ◽  
Patrick Lecomte ◽  
Natascha Deprez ◽  
Inge Van Pottelbergh ◽  
Paul Van Crombrugge ◽  
...  
Keyword(s):  
Glycaemic Control ◽  
Tight Glycaemic Control ◽  
Clinical Implementation

scholarly journals Eptacog Alfa (Activated) Is Physically and Chemically Stable over 24 Hours when Administered as Bolus Injections in an Automated Infusion Pump

TH Open ◽  
2019 ◽  
Vol 03 (01) ◽  
pp. e45-e49 ◽  
Author(s):  
Per Rexen ◽  
Jane Jensen ◽  
Nina Schwerin ◽  
Elena Kozina
Keyword(s):  
Bolus Injection ◽  
Infusion Pump ◽  
Hospital Setting ◽  
Factor Vii ◽  
Acceptance Criteria ◽  
Recombinant Activated Factor Vii ◽  
Pump System ◽  
Promising Alternative ◽  
Bolus Infusion

Introduction Eptacog alfa (activated) is a recombinant activated factor VII (rFVIIa) used for the treatment and prevention of bleeding episodes in patients with congenital hemophilia with inhibitors. Frequent dosing requirements make the use of an automated bolus infusion pump a promising alternative to manual administration. Aims The objective of this in vitro study was to evaluate the physical and chemical stability of room temperature–stable rFVIIa at 25°C over 24 hours in an automated bolus infusion pump. Methods An automated bolus infusion pump with preset bolus injection intervals of 2 to 6 hours was used. Samples of rFVIIa were analyzed for critical quality parameters, presence of leachables, and microbiological growth. The infusion system was evaluated visually. Results rFVIIa is physically and chemically stable when used in an automated bolus infusion pump system for up to 24 hours at 25°C. All critical quality parameter results were within the shelf-life limits and complied with the acceptance criteria. Leachables were observed at concentrations within their respective acceptance criteria. No visual changes in the syringe or infusion tube were observed; inherent particles in the reconstituted rFVIIa similar in size and description to those previously found in rFVIIa were seen. No microbiological growth was detected. Conclusions rFVIIa is stable in a bolus infusion pump system for up to 24 hours at 25°C. Bolus injection intervals of 2 to 6 hours can be used without physical or chemical changes to rFVIIa. This study supports the use of an automated bolus infusion pump in the hospital setting, across all indications for rFVIIa.

Nurse workload in implementing a tight glycaemic control protocol in a UK hospital: a pilot time-in-motion study

2012 ◽  
Vol 17 (6) ◽  
pp. 279-284 ◽  
Author(s):  
Juliane Gartemann ◽  
Elizabeth Caffrey ◽  
Nandini Hadker ◽  
Sheila Crean ◽  
Gary M. Creed ◽  
...  
Keyword(s):  
Glycaemic Control ◽  
Tight Glycaemic Control ◽  
Control Protocol ◽  
Motion Study ◽  
Nurse Workload

Spinal infusion pump-catheter leak detected by high-resolution 3D computed tomography

2011 ◽  
Vol 15 (5) ◽  
pp. 555-557 ◽  
Author(s):  
Jason A. Ellis ◽  
Richard Leung ◽  
Christopher J. Winfree
Keyword(s):  
High Resolution ◽  
Contrast Medium ◽  
Infusion Pump ◽  
Post Injection ◽  
3D Ct ◽  
Intrathecal Catheter ◽  
Pump System ◽  
Plain Radiographs ◽  
Iodinated Contrast ◽  
Catheter System

Implanted intrathecal drug delivery systems may malfunction as a result of fracture of the intrathecal catheter. A suspected catheter fracture not seen on plain radiographs of the catheter system will typically prompt a contrast-enhanced imaging study of the pump. Injection of iodinated contrast medium into the pump system with routine fluoroscopy can sometimes fail to reveal subtle leaks. The authors present a case demonstrating the utility of high-resolution, 3D-CT for intrathecal pump-catheter system interrogation when routine fluoroscopy is unrevealing. In this case, a catheter leak was suspected on the basis of the patient's history, but no obvious fracture was noted on plain radiographs. An intraoperative fluoroscopic study that included multiple injections of contrast medium into the catheter system failed to conclusively show a catheter leak. The authors therefore performed a post-injection 3D-CT study, which clearly demonstrated a leak from the intrathecal catheter just deep to the thoracolumbar fascia. The leak was visible on source images and was especially obvious after 3D reconstruction. This led to surgical revision of the catheter and subsequent resumption of normal pump function. The authors therefore suggest that if a leak is suspected in an implanted intrathecal catheter and routine contrast fluoroscopy is unrevealing, post-injection 3D-CT scanning should be performed to further investigate the possibility of a subtle leak.

Tight glycaemic control can be achieved while avoiding severe hypoglycaemia

2009 ◽  
Vol 33 (3) ◽  
pp. 230-231
Author(s):  
P. Davidson ◽  
R.D. Steed ◽  
B.W. Bode ◽  
H.R. Hebblewhite ◽  
N.S. Welch ◽  
...  
Keyword(s):  
Glycaemic Control ◽  
Severe Hypoglycaemia ◽  
Tight Glycaemic Control
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