scholarly journals Weighted-incidence syndromic combination antibiograms to guide empiric treatment of critical care infections: a retrospective cohort study

Critical Care ◽  
2014 ◽  
Vol 18 (3) ◽  
pp. R112 ◽  
Author(s):  
Varinder Randhawa ◽  
Syed Sarwar ◽  
Sandra Walker ◽  
Marion Elligsen ◽  
Lesley Palmay ◽  
...  
2020 ◽  
Vol 4 (4) ◽  
pp. 123
Author(s):  
Abdulmajeed Alhaidari ◽  
Maram Busuhail ◽  
Sara Alsultan ◽  
Sultan Alshammari ◽  
Abdullah Alshimemeri

2019 ◽  
Vol 39 (4) ◽  
pp. 13-19 ◽  
Author(s):  
Jenny Alderden ◽  
Yunchuan Lucy Zhao ◽  
Donna Thomas ◽  
Ryan Butcher ◽  
Brenda Gulliver ◽  
...  

Author(s):  
Isabelle Vock ◽  
Lisandra Aguilar-Bultet ◽  
Adrian Egli ◽  
Pranita D Tamma ◽  
Sarah Tschudin-Sutter

Abstract We investigated relative proportions of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) versus non-ESBL-PE (nESBL-PE) infections in ESBL-PE colonized patients. ESBL-PE are not causative for the majority of infections in hospitalized patients colonized with ESBL-PE. Site of infection and patient-level exposures may be useful predictors of nESBL-PE infections, potentially guiding empiric treatment recommendations.


CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A669
Author(s):  
Timothy Kable ◽  
Iaswarya Ganapathiraju ◽  
Samuel DuMontier ◽  
Rebecca Sabates ◽  
Jonathan Wadle ◽  
...  

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Nader Habib Bedwani ◽  
William English ◽  
Christopher Smith ◽  
Shailendra Singh ◽  
Paul Vulliamy ◽  
...  

Abstract Aims A better understanding of patient monitoring and outcomes is required following emergency laparotomy. We aimed to evaluate recovery following emergency laparotomy during the ‘first wave’ of the COVID-19 pandemic and assess for COVID-19-associated coagulopathy in this group. Methods We performed a single-centre, retrospective cohort study on adult patients undergoing emergency laparotomy from 23rdMarch – 16thMay 2020 comparing patients with or without suspected or confirmed SARS-CoV-2. Main outcome measures included; 30-day mortality, post-operative respiratory failure, ARDS and other complications, critical care admission and length of stay (CCLOS) and total length of stay (LOS). Laboratory results were collected for three days post-operatively including platelet counts and clotting screen. Results 33 patients undergoing 36 emergency laparotomies were included, of which 9 had confirmed or suspected COVID-19. Patients with COVID-19 were more likely to have severe complications (Clavien-Dindo grade ≥3) (9/9 vs 5/24; p < 0.001), post-operative respiratory failure (9/9 vs 2/24; p < 0.001), ARDS (3/9 vs 0/24; p = 0.015) and need for critical care stay (9/9 vs 12/24; p = 0.012) with a longer LOS and CCLOS (17 vs 7 days; p = 0.004 and 6 vs 1 day; p < 0.001 respectively). Platelet counts were consistently lower on all peri-operative days and patients had a higher incidence of coagulopathy (7/11 vs 3/17; p = 0.020). Conclusions Emergency laparotomy is associated with increased post-operative morbidity in patients with confirmed or suspected COVID-19 with increased respiratory complications and critical care stay. Post-operative patients with COVID-19 show mildly reduced platelet counts and deranged clotting that may be part of a COVID-19-associated coagulopathy.


Author(s):  
Thijs Feuth ◽  
Tarja Saaresranta ◽  
Antti Karlsson ◽  
Mika Valtonen ◽  
Ville Peltola ◽  
...  

Background: In the early phase of the coronavirus disease-19 (Covid-19) pandemic, Southwest Finland remained relatively spared. By the 3rd of May 2020, a total of 28 patients have been admitted to the Turku University Hospital. In this paper, we explore baseline characteristics in order to identify risk for severe Covid-19 disease and critical care admission. Methods For this retrospective cohort study, data were derived from hospital records. Basic descriptive statistics were used to characterise patients, including medians, percentiles and frequencies. Differences were tested with Mann Whitney U-test and Pearson's chi-square test. Results Pre-existent obstructive sleep apnoea (OSA) was present in 29% of patients admitted in the hospital for Covid-19, none of them having severe OSA. Overall, other findings on admission were comparable with those reported elsewhere. C-reactive protein (CRP) and procalcitonin (PCT) were higher in patients who were eventually transferred to critical care in comparison to in those who were not (median CRP 187 mg/L versus 52 mg/L, p<0.005 and median PCT 0.46 versus 0.12, p=0.047). Moreover, there was a trend towards lower oxygen saturation on admission in ICU-patients (87% versus 93%, p=0.09). Discussion OSA was pre-existent in a disproportional large group of patients, which suggests that it is an important risk factor for severe Covid-19. Furthermore, we identified high CRP, PCT and possibly oxygen saturation as useful clinical measures to identify patients at risk for critical care.


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