scholarly journals Age and decisions to limit life support for patients with acute lung injury: a prospective cohort study

Critical Care ◽  
2014 ◽  
Vol 18 (3) ◽  
pp. R107 ◽  
Author(s):  
Alison E Turnbull ◽  
Bryan M Lau ◽  
A Ruhl ◽  
Pedro A Mendez-Tellez ◽  
Carl B Shanholtz ◽  
...  
Keyword(s):  
Cohort Study ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Life Support

scholarly journals Lung protective mechanical ventilation and two year survival in patients with acute lung injury: prospective cohort study

BMJ ◽  
2012 ◽  
Vol 344 (apr05 2) ◽  
pp. e2124-e2124 ◽  
Author(s):  
D. M. Needham ◽  
E. Colantuoni ◽  
P. A. Mendez-Tellez ◽  
V. D. Dinglas ◽  
J. E. Sevransky ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Cohort Study ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Protective Mechanical Ventilation ◽  
Lung Protective Mechanical Ventilation

Six-month survival of patients with acute lung injury: Prospective cohort study*

2007 ◽  
Vol 35 (10) ◽  
pp. 2303-2308 ◽  
Author(s):  
Murat Yilmaz ◽  
Remzi Iscimen ◽  
Mark T. Keegan ◽  
Nicholas E. Vlahakis ◽  
Bekele Afessa ◽  
...  
Keyword(s):  
Cohort Study ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Prospective Cohort Study ◽  
Prospective Cohort

scholarly journals Early outcomes of tocilizumab in adults hospitalized with severe COVID-19 - The Vall d’Hebron COVID-19 prospective cohort study

2020 ◽  
Author(s):  
Adrián Sánchez-Montalvá ◽  
Júlia Sellarés-Nadal ◽  
Juan Espinosa-Pereiro ◽  
Nuria Fernández-Hidalgo ◽  
Santiago Pérez-Hoyos ◽  
...  
Keyword(s):  
Cohort Study ◽  
Lung Injury ◽  
Median Time ◽  
Prospective Cohort Study ◽  
Symptom Onset ◽  
Prospective Cohort ◽  
Hazard Ratio ◽  
University Hospital ◽  
Secondary Endpoints ◽  
Improve Patient

ABSTRACTBackgroundModulation of the immune system to prevent lung injury is being widely used against the new coronavirus disease (COVID-19) despite the scarcity of evidence.MethodsWe report the preliminary results from the Vall d’Hebron prospective cohort study at Vall d’Hebron University Hospital, in Barcelona (Spain), including all consecutive patients who had a confirmed infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and who were treated with tocilizumab until March 25th. The primary endpoint was mortality at 7 days after tocilizumab administration. Secondary endpoints were admission to the intensive care unit, development of ARDS and respiratory insufficiency among others.Results82 patients with COVID-19 received at least one dose of tocilizumab. The mean (± SD) age was 59.1 (19.8) years, 63% were male, 22% were of non-Spanish ancestry, and the median (IQR) age-adjusted Charlson index at baseline was 3 (1-4) points. Respiratory failure and ARDS developed in 62 (75.6%) and 45 (54.9%) patients, respectively. Median time from symptom onset to ARDS development was 8 (5-11) days. The median time from symptom onset to the first dose of tocilizumab was 9 (7-11) days. Mortality at 7 days was 26.8%. Hazard ratio for mortality was 3.3; 95% CI, 1.3 to 8.5 (age-adjusted hazard ratio for mortality 2.1; 95% CI, 0.8 to 5.8) if tocilizumab was administered after the onset of ARDS.ConclusionTime from lung injury onset to tocilizumab administration may be critical to patient recovery. Our preliminary data could inform bedside decisions until more data from clinical trials becomes available.Summary of the article’s main pointIn patient with COVID-19 and lung injury, time from lung injury onset to tocilizumab administration may be critical to patient recovery. Early administration of host-directed therapies may improve patient outcome.

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