scholarly journals Time-dependent apoptosis induction after spontaneous-breathing or ventilation-analogue experimental mechanostimulation of monolayer lung cell cultures

Critical Care ◽  
2014 ◽  
Vol 18 (Suppl 1) ◽  
pp. P279
Author(s):  
S Meyer ◽  
S Schumann ◽  
J Guttmann ◽  
K Gamerdinger
Keyword(s):  
Cell Cultures ◽  
Spontaneous Breathing ◽  
Time Dependent ◽  
Apoptosis Induction ◽  
Lung Cell Cultures

Time-dependent behavior of phenylpropanoid pathway in response to methyl jasmonate in Scrophularia striata cell cultures

2019 ◽  
Vol 39 (2) ◽  
pp. 227-243 ◽  
Author(s):  
Ehsan Sadeghnezhad ◽  
Mohsen Sharifi ◽  
Hassan Zare-Maivan ◽  
Najmeh Ahmadian Chashmi
Keyword(s):  
Methyl Jasmonate ◽  
Cell Cultures ◽  
Phenylpropanoid Pathway ◽  
Time Dependent ◽  
Dependent Behavior ◽  
Scrophularia Striata

Effects of Amiodarone on Elastin Biosynthesis in Primary Hamster Lung Cell Cultures

1991 ◽  
Vol 196 (4) ◽  
pp. 415-420
Author(s):  
K. A. Costa ◽  
J. M. Cerreta ◽  
N. Z. Baturay
Keyword(s):  
Cell Cultures ◽  
Lung Cell Cultures

scholarly journals Curcuma longa Linn extract suppresses neuronal apoptosis induction by sevoflurane via activation of the ERK1/2 pathway

2022 ◽  
Vol 20 (2) ◽  
pp. 269-274
Author(s):  
Zhou Yu ◽  
Yao Yan ◽  
Ying Lou
Keyword(s):  
Neuronal Apoptosis ◽  
Caspase 3 ◽  
Neuronal Damage ◽  
Curcuma Longa ◽  
Inhibitory Effect ◽  
Time Dependent ◽  
Apoptosis Induction ◽  
Viability Assessment ◽  
Neuronal Proliferation ◽  
Induced Apoptosis

Purpose: To investigate Curcuma longa Linn against neuronal damage induced by exposure to sevoflurane during surgical procedures. Methods: A sealed box made of transparent glass was used for anaesthetic exposure of neurons. The neurons were exposed to Curcuma longa Linn at doses of 1.5, 3, 6 and 12 μM prior to viability assessment using MTT assay. The effect of Curcuma longa Linn treatment on protein expression was determined using western blotting. Results: Sevoflurane exposure led to significant and time-dependent reductions in neuronal proliferation, when compared to unexposed cells (p < 0.05). Curcuma longa Linn at doses of 1.5, 3, 6 and 12 μM significantly decreased sevoflurane-mediated neuronal apoptosis. It reduced cleaved caspase-3 and Bax levels in neurons. However, the Curcuma longa Linn-mediated inhibition of sevoflurane-induced neuronal apoptosis was significantly suppressed by VPC23019 (p < 0.05). The p- ERK1/2 level was dose-dependently up-regulated in neurons exposed to sevoflurane on treatment with Curcuma longa Linn. Moreover, VPC23019 reversed the upregulatory effect of Curcuma longa Linn on p-ERK1/2 expression in sevoflurane-exposed neurons (p < 0.05). Conclusion: Curcuma longa Linn reversed sevoflurane-induced neuronal apoptosis by elevating p- ERK1/2 expression. Therefore, Curcuma longa Linn exerts inhibitory effect on anaesthesia-induced apoptosis in neurons, and may be useful for the treatment of this condition.

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