scholarly journals Effect of low-dose hydrocortisone on gene expression profiles after severe burn injury

Critical Care ◽  
2014 ◽  
Vol 18 (Suppl 1) ◽  
pp. P75
Author(s):  
J Plassais ◽  
MA Cazalis ◽  
F Venet ◽  
G Monneret ◽  
A Pachot ◽  
...  
Keyword(s):  
Gene Expression ◽  
Low Dose ◽  
Burn Injury ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Severe Burn ◽  
Severe Burn Injury

scholarly journals PSIV-11 Effects of very low-dose antibiotics on gene expression profiles in ileal mucosa of weaned pigs infected with a pathogenic E. coli

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 286-286
Author(s):  
Kwangwook Kim ◽  
Sungbong Jang ◽  
Yanhong Liu
Keyword(s):  
Gene Expression ◽  
Systemic Inflammation ◽  
Low Dose ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Post Inoculation ◽  
Growth Promoter ◽  
Weaned Pigs ◽  
Ileal Mucosa ◽  
E Coli

Abstract Our previous studies have shown that supplementation of low-dose antibiotic growth promoter (AGP) exacerbated growth performance and systemic inflammation of weaned pigs infected with pathogenic Escherichia coli (E. coli). The objective of this experiment, which is extension of our previous report, was to investigate the effect of low-dose AGP on gene expression in ileal mucosa of weaned pigs experimentally infected with F18 E. coli. Thirty-four pigs (6.88 ± 1.03 kg BW) were individually housed in disease containment rooms and randomly allotted to one of three treatments (9 to 13 pigs/treatment). The three dietary treatments were control diet (control), and 2 additional diets supplemented with 0.5 or 50 mg/kg of AGP (carbadox), respectively. The experiment lasted 18 d [7 d before and 11 d after first inoculation (d 0)]. The F18 E. coli inoculum was orally provided to all pigs with the dose of 1010 cfu/3 mL for 3 consecutive days. Total RNA [4 to 6 pigs/treatment on d 5; 5 to 7 pigs/treatment on 11 post-inoculation (PI)] was extracted from ileal mucosa to analyze gene expression profiles by Batch-Tag-Seq. The modulated differential gene expression were defined by 1.5-fold difference and a cutoff of P < 0.05 using limma-voom package. All processed data were statistically analyzed and evaluated by PANTHER classification system to determine the biological process function of genes in these lists. Compared to control, supplementation of recommended-dose AGP down-regulated genes related to inflammatory responses on d 5 and 11 PI; whereas, feeding low-dose AGP up-regulated genes associated with negative regulation of metabolic process on d 5, but down-regulated the genes related to immune responses on d 11 PI. The present observations support adverse effects of low-dose AGP in our previous study, indicated by exacerbated the detrimental effects of E. coli infection on pigs’ growth rate, diarrhea and systemic inflammation.

scholarly journals Toll like receptors gene expression of human keratinocytes cultured of severe burn injury

2014 ◽  
Vol 29 (suppl 3) ◽  
pp. 33-38 ◽  
Author(s):  
Sarita Mac Cornick ◽  
Silvana Aparecida Alves Corrêa de Noronha ◽  
Samuel Marcos Ribeiro de Noronha ◽  
Marcus V. B. Cezillo ◽  
Lydia Masako Ferreira ◽  
...  
Keyword(s):  
Gene Expression ◽  
Burn Injury ◽  
Human Keratinocytes ◽  
Severe Burn ◽  
Toll Like Receptors ◽  
Severe Burn Injury

scholarly journals 0041. The effect of low-dose hydrocortisone after severe burn injury: a microarray longitudinal study

2014 ◽  
Vol 2 (S1) ◽  
Author(s):  
J Textoris ◽  
J Plassais ◽  
M-A Cazalis ◽  
F Venet ◽  
T Rimmele ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Low Dose ◽  
Burn Injury ◽  
Severe Burn ◽  
Severe Burn Injury

Screening of Key Genes in Severe Burn Injury at Different Stages via Analyzing Gene Expression Data

2016 ◽  
Vol 37 (3) ◽  
pp. e254-e262 ◽  
Author(s):  
Zhihong Li ◽  
Qihong Wang ◽  
Haifeng Yu ◽  
Kun Zou ◽  
Yong Xi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Data ◽  
Burn Injury ◽  
Expression Data ◽  
Severe Burn ◽  
Key Genes ◽  
Severe Burn Injury

scholarly journals Cellular responses and gene expression profiles of colonic Lgr5+ stem cells after low-dose/low-dose-rate radiation exposure

2017 ◽  
Vol 59 (suppl_2) ◽  
pp. ii18-ii22 ◽  
Author(s):  
Kensuke Otsuka ◽  
Keiji Suzuki ◽  
Yuki Fujimichi ◽  
Masanori Tomita ◽  
Toshiyasu Iwasaki
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Radiation Exposure ◽  
Dose Rate ◽  
Low Dose ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Cellular Responses ◽  
Low Dose Rate

scholarly journals Innate and adaptive immunity gene expression of human keratinocytes cultured of severe burn injury

2014 ◽  
Vol 29 (suppl 3) ◽  
pp. 60-67 ◽  
Author(s):  
Silvana Aparecida Alves Corrêa de Noronha ◽  
Samuel Marcos Ribeiro de Noronha ◽  
Larissa Elias Lanziani ◽  
Lydia Masako Ferreira ◽  
Alfredo Gragnani
Keyword(s):  
Gene Expression ◽  
Adaptive Immunity ◽  
Burn Injury ◽  
Human Keratinocytes ◽  
Severe Burn ◽  
Innate And Adaptive Immunity ◽  
Immunity Gene ◽  
Severe Burn Injury
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