scholarly journals Peroxisome proliferator-activated receptor agonist rosiglitazone improves host defense against Pseudomonas aeruginosa in a murine model of pneumonia

Critical Care ◽  
2013 ◽  
Vol 17 (Suppl 4) ◽  
pp. P111
Author(s):  
Crisitina Nagae ◽  
Cassiano Gonçalves-de-Albuquerque ◽  
Alessandra Ferreira ◽  
Raysa Captivo ◽  
Larissa Camisão ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Host Defense ◽  
Murine Model ◽  
Receptor Agonist ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor

scholarly journals The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis

2017 ◽  
Vol 1 (6) ◽  
pp. 524-537 ◽  
Author(s):  
Guillaume Wettstein ◽  
Jean-Michel Luccarini ◽  
Laurence Poekes ◽  
Patrick Faye ◽  
Francine Kupkowski ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Metabolic Disorders ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
New Generation

scholarly journals Autophagy-activating strategies to promote innate defense against mycobacteria

2019 ◽  
Vol 51 (12) ◽  
pp. 1-10 ◽  
Author(s):  
Yi Sak Kim ◽  
Prashanta Silwal ◽  
Soo Yeon Kim ◽  
Tamotsu Yoshimori ◽  
Eun-Kyeong Jo
Keyword(s):  
Host Defense ◽  
Defense Mechanism ◽  
Multidrug Resistant ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Innate Defense ◽  
Host Defense Mechanism ◽  
A Cell

AbstractMycobacterium tuberculosis (Mtb) is a major causal pathogen of human tuberculosis (TB), which is a serious health burden worldwide. The demand for the development of an innovative therapeutic strategy to treat TB is high due to drug-resistant forms of TB. Autophagy is a cell-autonomous host defense mechanism by which intracytoplasmic cargos can be delivered and then destroyed in lysosomes. Previous studies have reported that autophagy-activating agents and small molecules may be beneficial in restricting intracellular Mtb infection, even with multidrug-resistant Mtb strains. Recent studies have revealed the essential roles of host nuclear receptors (NRs) in the activation of the host defense through antibacterial autophagy against Mtb infection. In particular, we discuss the function of estrogen-related receptor (ERR) α and peroxisome proliferator-activated receptor (PPAR) α in autophagy regulation to improve host defenses against Mtb infection. Despite promising findings relating to the antitubercular effects of various agents, our understanding of the molecular mechanism by which autophagy-activating agents suppress intracellular Mtb in vitro and in vivo is lacking. An improved understanding of the antibacterial autophagic mechanisms in the innate host defense will eventually lead to the development of new therapeutic strategies for human TB.

The effects of Peroxisome Proliferator-Activated Receptor-γ agonist on a murine model of experimental allergic rhinitis

2008 ◽  
Vol 139 (1) ◽  
pp. 124-130 ◽  
Author(s):  
Eun-Ju Jeon ◽  
Seung Kyun Lee ◽  
Yong-Soo Park ◽  
Dong-Hyun Kim ◽  
Jin Ho Yum ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Murine Model ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Experimental Allergic
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