scholarly journals Heparin-binding protein improves prediction of severe sepsis in the emergency department

Critical Care ◽  
2013 ◽  
Vol 17 (Suppl 4) ◽  
pp. P3 ◽  
Author(s):  
Adam Linder ◽  
Ryan Arnold ◽  
Marco Zindovic ◽  
Igor Zindovic ◽  
Anna Lange-Jendeberg ◽  
...  
Keyword(s):  
Emergency Department ◽  
Severe Sepsis ◽  
Binding Protein ◽  
Heparin Binding ◽  
Heparin Binding Protein

Heparin Binding Protein for The Early Diagnosis and Prognosis Of Sepsis In The Emergency Department

Shock ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Konstantinos Katsaros ◽  
Georgios Renieris ◽  
Asimina Safarika ◽  
Evangelia-Maria Adami ◽  
Theologia Gkavogianni ◽  
...  
Keyword(s):  
Emergency Department ◽  
Early Diagnosis ◽  
Binding Protein ◽  
Heparin Binding ◽  
Diagnosis And Prognosis ◽  
Heparin Binding Protein

scholarly journals Heparin-Binding Protein as a Prognostic Biomarker of Sepsis and Disease Severity at the Emergency Department

Shock ◽  
2019 ◽  
Vol 52 (6) ◽  
pp. e135-e145 ◽  
Author(s):  
Fredrik Kahn ◽  
Jonas Tverring ◽  
Lisa Mellhammar ◽  
Nils Wetterberg ◽  
Anna Bläckberg ◽  
...  
Keyword(s):  
Emergency Department ◽  
Disease Severity ◽  
Prognostic Biomarker ◽  
Binding Protein ◽  
Heparin Binding ◽  
Heparin Binding Protein

scholarly journals Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock

Critical Care ◽  
2012 ◽  
Vol 16 (3) ◽  
pp. R90 ◽  
Author(s):  
Adam Linder ◽  
Per Åkesson ◽  
Malin Inghammar ◽  
Carl-Johan Treutiger ◽  
Anna Linnér ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Septic Shock ◽  
Severe Sepsis ◽  
Intensive Care ◽  
Plasma Levels ◽  
Binding Protein ◽  
Heparin Binding ◽  
Elevated Plasma ◽  
Heparin Binding Protein ◽  
Sepsis And Septic Shock

scholarly journals Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department

2015 ◽  
Vol 43 (11) ◽  
pp. 2378-2386 ◽  
Author(s):  
Adam Linder ◽  
Ryan Arnold ◽  
John H. Boyd ◽  
Marko Zindovic ◽  
Igor Zindovic ◽  
...  
Keyword(s):  
Emergency Department ◽  
Organ Dysfunction ◽  
Binding Protein ◽  
Severe Infection ◽  
Heparin Binding ◽  
Heparin Binding Protein ◽  
Protein Measurement

scholarly journals Heparin-Binding Protein in Critically Ill Children With Severe Community-Acquired Pneumonia

2021 ◽  
Vol 9 ◽  
Author(s):  
Caizhi Huang ◽  
Cong Zhang ◽  
Jie Zhang ◽  
Lin Zhang ◽  
Yi Mo ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Critically Ill ◽  
Binding Protein ◽  
Community Acquired Pneumonia ◽  
Critically Ill Children ◽  
Heparin Binding ◽  
Heparin Binding Protein ◽  
Number Of Patients ◽  
Severe Community Acquired Pneumonia ◽  
D Dimer

Objective: The aim of this study was to investigate possible associations between Heparin-binding protein (HBP) and the development of respiratory failure (RF) and sepsis in critically ill children with severe community-acquired pneumonia (CAP).Methods: This study enrolled 157 children with severe CAP admitted to Intensive Care Unit (ICU). At ICU admission, the levels of HBP and other biomarkers, including C-reactive protein, interleukin-6 (IL-6), procalcitonin, white blood cells, neutrophil percentage, and D-dimer, were determined.Results: Of the enrolled patients, 106 developed RF (35 with RF at enrollment and 71 with RF after enrollment), while 51 did not developed RF. The number of patients progressing to sepsis in those with or without RF were 34 (21 with severe sepsis) and 14, respectively. The plasma level of HBP at admission was more than eightfold higher than the upper normal value. HBP, IL-6, and D-dimer could significantly predict the development of RF, and a high level of HBP (odds ratio = 1.008, 95% confidence interval: 1.003–1.013) was independently associated with the development of RF in this population. Compared with other biomarkers, HBP was the best indicator of progression to severe sepsis, with an area under the receiver operating characteristic curve of 0.85, the best specificity at 96.30%, and a positive predictive value of 92.86% at the optimal cut-off value of 340.29 ng/mL. The HBP level was also positively correlated with other conventional biomarkers.Conclusion: HBP might represent a better predictor of disease progression in children with severe CAP than currently used biomarkers.

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