scholarly journals Dosing patterns for continuous renal replacement therapy in the United States

Critical Care ◽  
2001 ◽  
Vol 5 (Suppl 1) ◽  
pp. P216
Author(s):  
R Venkataraman ◽  
JA Kellum
2016 ◽  
Vol 36 (6) ◽  
pp. 691-693
Author(s):  
Achint Patel ◽  
Harshil Shah ◽  
Shanti Patel ◽  
Girish N. Nadkarni ◽  
Jaime Uribarri

Peritoneal dialysis (PD) is an effective but underutilized renal replacement therapy modality. There are limited data regarding geographical variation in PD catheter insertion and utilization of PD as a first renal replacement therapy in the United States. We explored the variation in catheter insertion and initiation of PD utilizing 2 large, nationally representative databases. The incidence of catheter insertion differed significantly by geographical region, being highest in the South (7.30/100 end-stage renal disease [ESRD] patients; 95% confidence [CI] interval 6.78 – 7.81) and lowest in the West (5.91/100 ESRD patients; 95% CI 5.43 – 6.38). Peritoneal dialysis initiation also differed by region, being highest in the West (7.10/100 ESRD patients; 95% CI 6.83 – 7.30) and lowest in the Northeast (5.12/100 ESRD patients; 95% CI 4.87 – 5.30). Interestingly, the Northeast region, with the lowest rate of PD utilization, had the highest number of nephrologists per population (3.95/100,000 persons), and the West, with the highest PD utilization, had the lowest number of nephrologists (2.54/100,000 persons). Reasons for this variation should be explored further and efforts should be made to standardize PD implementation throughout the United States.


2018 ◽  
Vol 46 (2) ◽  
pp. e158-e165 ◽  
Author(s):  
Thomas S. Valley ◽  
Brahmajee K. Nallamothu ◽  
Michael Heung ◽  
Theodore J. Iwashyna ◽  
Colin R. Cooke

Nephron ◽  
2021 ◽  
pp. 1-7
Author(s):  
Tananchai Petnak ◽  
Charat Thongprayoon ◽  
Wisit Cheungpasitporn ◽  
Khaled Shawwa ◽  
Michael A. Mao ◽  
...  

Background: Serum sodium derangement is common in critically ill patients requiring continuous renal replacement therapy (CRRT). We aimed to assess the association between serum sodium before and during CRRT with mortality. Methods: This is a historical cohort study of 1,520 critically ill patients receiving CRRT from December 2006 through November 2015 in a tertiary hospital in the United States. Using logistic regression analysis, we used serum sodium before CRRT, mean serum sodium, and serum sodium changes during CRRT to predict 90-day mortality after CRRT initiation. Results: Compared with the normal serum sodium levels, the odds ratio (OR) of 90-day mortality in patients with serum sodium before CRRT of 143–147 and ≥148 mmol/L were 1.45 (95% CI 1.03–2.05) and 2.24 (95% CI 1.33–3.87), respectively. There was no significant increase in 90-day mortality in serum sodium of ≤137 mmol/L. During CRRT, the mean serum sodium levels of ≤137 (OR 1.41; 95% CI 1.01–1.98) and ≥143 mmol/L (OR 1.52; 95% CI 1.14–2.03) were associated with higher 90-day mortality. The greater serum sodium changes during CRRT were associated with higher 90-mortality (OR 1.35; 95% CI 1.21–1.51 per 5-mmol/L increase). Conclusion: Before CRRT initiation, hypernatremia and during CRRT, hypo- and hypernatremia were associated with increased mortality.


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