scholarly journals Clinical outcomes of patients requiring ventilatory support in Brazilian intensive care units: a multicenter, prospective, cohort study

Critical Care ◽  
2013 ◽  
Vol 17 (2) ◽  
Author(s):  
Luciano CP Azevedo ◽  
◽  
Marcelo Park ◽  
Jorge IF Salluh ◽  
Alvaro Rea-Neto ◽  
...  
Keyword(s):  
Cohort Study ◽  
Intensive Care ◽  
Clinical Outcomes ◽  
Intensive Care Units ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Ventilatory Support ◽  
Multicenter Prospective Cohort Study ◽  
Multicenter Prospective Cohort

scholarly journals Acute renal failure in children. Multicenter prospective cohort study in medium-complexity intensive care units from the Colombian southeast

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0235976
Author(s):  
Jaime M. Restrepo ◽  
Mónica V. Mondragon ◽  
Jessica M. Forero-Delgadillo ◽  
Rubén E. Lasso ◽  
Eliana Zemanate ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Cohort Study ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Multicenter Prospective Cohort Study ◽  
Multicenter Prospective Cohort

scholarly journals Relationship Between The Appropriateness of Antibiotic Treatment and Clinical Outcomes of Patients With Community-Acquired Acute Pyelonephritis: A Multicenter Prospective Cohort Study

2021 ◽  
Author(s):  
Choseok Yoon ◽  
Se Yoon Park ◽  
Bongyoung Kim ◽  
Ki Tae Kwon ◽  
Seong-yeol Ryu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Outcomes ◽  
Antibiotic Treatment ◽  
Prospective Cohort Study ◽  
Acute Pyelonephritis ◽  
Prospective Cohort ◽  
Clinical Symptoms ◽  
Medical Costs ◽  
Multicenter Prospective Cohort Study ◽  
Multicenter Prospective Cohort

Abstract Background Inappropriate use of antibiotics not only increases antibiotic resistance as collateral damage but also increases clinical failure rates and medical costs. The purpose of this study was to determine the relationship between the appropriateness of antibiotic prescription and clinical outcomes of community-acquired acute pyelonephritis (CA-APN). Methods A multicenter prospective cohort study was conducted at eight hospitals in Korea between September 2017 and August 2018. All hospitalized patients aged ≥ 19 years who were diagnosed with CA-APN on admission were recruited. The appropriateness of empirical and definitive antibiotics, as well as the appropriateness of antibiotic treatment duration and route of administration, was evaluated. Clinical outcomes were compared between patients who were administered antibiotics ‘appropriately’ and ‘inappropriately.’ Results A total of 397 and 318 patients were eligible for the analysis of the appropriateness of empirical and definitive antibiotics, respectively. Of them, 10 (2.5%) and 18 (5.7%) were administered ‘inappropriately’ empirical and definitive antibiotics, respectively. Of the 119 patients whose use of both empirical and definitive antibiotics was classified as ‘optimal,’ 57 (47.9%) received antibiotics over a longer duration than that recommended; 67 (56.3%) did not change to oral antibiotics on day 7 of hospitalization, even after stabilization of the clinical symptoms. Patients who were administered empirical antibiotics ‘appropriately’ had shorter hospitalization days (9 vs. 12.5 days, P = 0.014) and lower medical costs (2,332.7 vs. 4,531.2 USD, P = 0.007) than those who were administered them ‘inappropriately.’ Similar findings were observed for patients administered both empirical and definitive antibiotics ‘appropriately’ and those administered either empirical or definitive antibiotics ‘inappropriately’ Conclusions Appropriate use of antibiotics leads to better clinical outcomes, including reduced hospitalization duration and medical costs.

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