scholarly journals Differences of calcium binding protein immunoreactivities in the young hippocampal CA1 region from the adult following transient ischemic damage

Critical Care ◽  
2013 ◽  
Vol 17 (S2) ◽  
Author(s):  
CW Park ◽  
HY Lee ◽  
JH Cho ◽  
MH Won
Keyword(s):  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Ischemic Damage ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Hippocampal Ca1

scholarly journals Ischemic Damage and Subsequent Proliferation of Oligodendrocytes in Hippocampal CA1 Region following Repeated Brief Cerebral Ischemia

Pathobiology ◽  
2009 ◽  
Vol 76 (4) ◽  
pp. 204-211 ◽  
Author(s):  
Hiro Eda ◽  
Shigeru Sato ◽  
Yoshihiro Sasaki ◽  
Akiko Adachi ◽  
Mohammad Ghazizadeh
Keyword(s):  
Cerebral Ischemia ◽  
Ischemic Damage ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Hippocampal Ca1

Fast spiking cells in rat hippocampus (CA1 region) contain the calcium-binding protein parvalbumin

1987 ◽  
Vol 416 (2) ◽  
pp. 369-374 ◽  
Author(s):  
Yasuo Kawaguchi ◽  
Hironobu Katsumaru ◽  
Toshio Kosaka ◽  
Claus W. Heizmann ◽  
Kiyoshi Hama
Keyword(s):  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Rat Hippocampus ◽  
Ca1 Region ◽  
Fast Spiking

Age-related changes in ionized calcium-binding adapter molecule 1 in the gerbil hippocampal CA1 region

2007 ◽  
Vol 58 ◽  
pp. S74
Author(s):  
Jung Hoon Choi ◽  
Choong Hyun Lee ◽  
Dae Won Chung ◽  
In Ku Hwang ◽  
Moo Ho Won ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Ionized Calcium ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Age Related ◽  
Hippocampal Ca1 ◽  
Adapter Molecule ◽  
Age Related Changes

Ionized Calcium-binding Adapter Molecule 1 Immunoreactive Cells Change in the Gerbil Hippocampal CA1 Region after Ischemia/Reperfusion

2006 ◽  
Vol 31 (7) ◽  
pp. 957-965 ◽  
Author(s):  
In Koo Hwang ◽  
Ki-Yeon Yoo ◽  
Dae Won Kim ◽  
Soo Young Choi ◽  
Tae-Cheon Kang ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Ischemia Reperfusion ◽  
Ionized Calcium ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Hippocampal Ca1 ◽  
Adapter Molecule

scholarly journals Neuroprotective Effects of Purpurin Against Ischemic Damage via Anti-inflammatory and MAPK Pathway

2021 ◽  
Author(s):  
Woosuk Kim ◽  
Hyun Jung Kwon ◽  
Hyo Young Jung ◽  
Kyu Ri Hahn ◽  
Yeo Sung Yoon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mapk Pathway ◽  
Ischemic Damage ◽  
Neuroprotective Effects ◽  
Ht22 Cells ◽  
Protein Levels ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Hippocampal Ca1 ◽  
Anti Inflammatory

Abstract Purpurin has various effects, including anti-inflammatory effects, and can efficiently cross the blood-brain barrier. In the present study, we investigated the effects of purpurin on oxidative stress in HT22 cells and ischemic damage in the hippocampal CA1 region of gerbils. Oxidative stress induced by H2O2 was significantly ameliorated by treatment with purpurin, based on changes in cell death, DNA fragmentation, formation of reactive oxygen species, and apoptosis (Bcl-2)/antiapoptosis (Bax)-related protein levels. In addition, treatment with purpurin significantly reduced the phosphorylation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase 1/2 (ERK), and p38 signaling in HT22 cells. Transient forebrain ischemia in gerbils led to a significant increase in locomotor activity 1 day after ischemia and significant decrease in number of surviving cells in the CA1 region 4 days after ischemia. Administration of purpurin reduced the travel distance 1 day after ischemia and increased the number of NeuN-immunoreactive neurons in the hippocampal CA1 region of the dentate gyrus 4 days after ischemia. Purpurin treatment significantly decreased microglial activation in the hippocampal CA1 region 4 days after ischemia and ameliorated the ischemia-induced increases in interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α 6 h after ischemia. In addition, purpurin significantly alleviated the ischemia-induced phosphorylation of JNK, ERK, and p38 in the hippocampus 1 day after ischemia. These results suggest that purpurin has neuroprotective potential to reduce inflammatory processes and the phosphorylation of JNK, ERK, and p38 in the hippocampus.

Sign in / Sign up

Export Citation Format

Share Document