scholarly journals Empirical versus preemptive antimycotic therapy in terms of outcome benefit

Critical Care ◽  
2013 ◽  
Vol 17 (S2) ◽  
Author(s):  
S Milanov ◽  
VT Todorova ◽  
G Georgiev ◽  
M Milanov
Keyword(s):  
Antimycotic Therapy

Newer patents in antimycotic therapy

2016 ◽  
Vol 5 (2) ◽  
pp. 115-134 ◽  
Author(s):  
Sukhbir K Shahid
Keyword(s):  
Antimycotic Therapy

Oral Candida and Entembacteriaceae in HIV-1 infection: correlation with clinical candidiasis and antimycotic therapy

1991 ◽  
Vol 20 (10) ◽  
pp. 469-472 ◽  
Author(s):  
Andrea Schmidt-Westhausen ◽  
Reinhold-Andreas Schiller ◽  
Hans Dieter Pohle ◽  
Peter A. Reichart
Keyword(s):  
Antimycotic Therapy ◽  
Oral Candida ◽  
Hiv 1

scholarly journals Detection of Paracoccidioides brasiliensis gp70 Circulating Antigen and Follow-Up of Patients Undergoing Antimycotic Therapy

2004 ◽  
Vol 42 (10) ◽  
pp. 4480-4486 ◽  
Author(s):  
S. H. Marques da Silva ◽  
D. de Mattos Grosso ◽  
J. D. Lopes ◽  
A. L. Colombo ◽  
M. H. S. L. Blotta ◽  
...  
Keyword(s):  
Paracoccidioides Brasiliensis ◽  
Antimycotic Therapy ◽  
Circulating Antigen

Systemic antimycotic therapy of patients with mycosis of the oral mucosa and periodontal Сandida etiology

2021 ◽  
pp. 70-76
Author(s):  
R. V. Ushakov ◽  
V. N. Tsarev ◽  
Т. V. Ushakova ◽  
Т. V. Tsareva ◽  
A. R. Ushakov ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Oral Mucosa ◽  
Traditional Method ◽  
Fungicidal Activity ◽  
Oral Candidiasis ◽  
Chromogenic Medium ◽  
Antimycotic Therapy ◽  
Yeast Fungi ◽  
Scanning Electron

Candidiasis is the most common mycosis. Оral candidiasis occurs in the form of stomatitis, including the so-called prosthetic stomatitis. Somewhat less often, fungi of the genus Candida are detected with gingivitis and periodontitis, manifestations of red lichen planus on the oral mucosa.The purpose of the work: to analyze the results of mycological studies and determine the sensitivity of fungi isolated from the oral cavity in vari-ous oral pathologies to the main antimycotics, as well as the formation on this basis of an algorithm for antimycotic therapy of candidal lesions of the oral mucosa and periodontium.Material and methods. The paper uses the results of studies of patients with candidiasis of the oral mucosa (127 patients), prosthetic stomatitis (136 patients), candida-associated periodontitis (168 patients). Primary inoculation was performed quantitatively on Sabouraud’s medium and duplicated on M1297 chromogenic medium (Himedia Labs, India).To study the biofilm formed on the oral mucosa, fixed preparations of gold-coated scrapings were prepared for scanning electron microscopy, which was performed using a Quanta 200 3D bi-beam microscope (USA). Sensitivity to antimycotics was assessed using the traditional method of disks.The results of the study. When studying the species composition of yeast-like fungi isolated from the material, it was found that the species C. albicans was isolated in 80% of patients, in association with other species: C. Krusei, C. guilliermondii and C. glabrata. The second place was taken by the species C. Krusei, which was detected in 13.3% of patients. Representatives of this genus of yeast fungi are characterized by the formation of a biofilm with a pronounced mantle, which protects the microorganism from aggressive factors, including antimycotics and antiseptics. All the studied preparations showed fungicidal activity against these strains of yeast-like fungi. When registering the results, it was found that the most pronounced sensitivity of yeast-like fungi of this species was to drugs from the group of azole derivatives. The most pronounced antifungal activity was noted by us in voriconazole.Conclusion. Based on the obtained data, an algorithm of systemic antimycotic therapy for oral candidiasis has been developed.

scholarly journals Allergic bronchopulmonary aspergillosis in patients with asthma: dynamics of immunological parameters during antimycotic therapy

2016 ◽  
Vol 13 (6) ◽  
pp. 37-42
Author(s):  
Y I Kozlova ◽  
A V Sobolev ◽  
E V Frolova ◽  
A E Uchevatkina ◽  
L V Filippova ◽  
...  
Keyword(s):  
Allergic Bronchopulmonary Aspergillosis ◽  
Specific Ige ◽  
Absolute Number ◽  
Skin Tests ◽  
Immunological Parameters ◽  
Total Ige ◽  
Antimycotic Therapy ◽  
Fungal Allergens ◽  
Ifn Γ ◽  
Serum Total Ige

Background. To determine the frequency of allergic bronchopulmonary aspergillosis in patients with asthma and to study the dynamics of immunological parameters in patients with allergic bronchopulmonary aspergillosis during antimycotic therapy. Methods. During investigation of 176 patients with asthma the group of patients with allergic bronchopulmonary aspergillosis was isolated. Allergological (skin tests with fungal allergens, serum total IgE, specific IgE to fungal allergens), immunological (IFN-γ, IL-10) and mycological (microscopy and culture of respiratory samples) examination was performed. Computer tomography of the chest was done when indicated. Results. In patients with asthma frequency of sensitization to Aspergillus spp. was 27%, with allergic bronchopulmonary aspergillosis - 4%. The increased activity of T-helper type 2 in patients with allergic bronchopulmonary aspergillosis (n=7) was revealed. After itraconazole treatment during 24 weeks serum total IgE reduced (p=0,04), spontaneous and induced production of IFN-γ ratio was normalized. The reduction of the absolute number of eosinophils in 4 (80%) patients, decreased production of sIgE to Aspergillus spp. in 3 (60%) patients were noted. Conclusion. All patients with severe asthma needed additional allergological and mycological examination for the detection of allergic bronchopulmonary aspergillosis. Itraconazole therapy was effective, reduced fungal burden, and resulted to restoring of Th2/Th1 imbalance in patients with allergic bronchopulmonary aspergillosis.

scholarly journals Efficacy and utility of a protocol for pre-emptive antimycotic therapy

Critical Care ◽  
2010 ◽  
Vol 14 (Suppl 1) ◽  
pp. P70 ◽  
Author(s):  
SG Milanov ◽  
G Georgiev ◽  
V Todorova ◽  
L Kozarov ◽  
M Milanov
Keyword(s):  
Antimycotic Therapy
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