scholarly journals Protective role of autophagy in mouse cecal ligation and puncture-induced sepsis model

Critical Care ◽  
2013 ◽  
Vol 17 (S2) ◽  
Author(s):  
W Takahashi ◽  
H Hatano ◽  
H Hirasawa ◽  
S Oda
Keyword(s):  
Cecal Ligation ◽  
Protective Role ◽  
Cecal Ligation And Puncture ◽  
Sepsis Model

scholarly journals Kinetics and protective role of autophagy in a mouse cecal ligation and puncture-induced sepsis

Critical Care ◽  
2013 ◽  
Vol 17 (4) ◽  
pp. R160 ◽  
Author(s):  
Waka Takahashi ◽  
Eizo Watanabe ◽  
Lisa Fujimura ◽  
Haruko Watanabe-Takano ◽  
Hiroyuki Yoshidome ◽  
...  
Keyword(s):  
Cecal Ligation ◽  
Protective Role ◽  
Cecal Ligation And Puncture

scholarly journals Protective Role of Coenzyme Q10 in Acute Sepsis-Induced Liver Injury in BALB/c Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Qian-wei Li ◽  
Qin Yang ◽  
Hong-Yang Liu ◽  
Yu-ling Wu ◽  
Yu-Hua Hao ◽  
...  
Keyword(s):  
Liver Injury ◽  
Coenzyme Q10 ◽  
Cecal Ligation ◽  
Protective Role ◽  
Hepatic Tissue ◽  
Control Group ◽  
Cecal Ligation And Puncture ◽  
Sequestosome 1

Sepsis increases the risk of the liver injury development. According to the research works, coenzyme Q10 exhibits hepatoprotective properties in vivo as well as in vitro. Current work aimed at investigating the protective impacts of coenzyme Q10 against liver injury in septic BALB/c mice. The male BALB/c mice were randomly segregated into 4 groups: the control group, the coenzyme Q10 treatment group, the puncture and cecal ligation group, and the coenzyme Q10+cecal ligation and puncture group. Cecal ligation and puncture was conducted after gavagaging the mice with coenzyme Q10 during two weeks. Following 48 h postcecal ligation and puncture, we estimated hepatic biochemical parameters and histopathological changes in hepatic tissue. We evaluated the expression of factors associated with autophagy, pyroptosis, and inflammation. Findings indicated that coenzyme Q10 decreased the plasma levels in alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase in the cecal ligation and puncture group. Coenzyme Q10 significantly inhibited the elevation of sequestosome-1, interleukin-1β, oligomerization domain-like receptor 3 and nucleotide-binding, interleukin-6, and tumor necrosis factor-α expression levels; coenzyme Q10 also increased beclin 1 levels. Coenzyme Q10 might be a significant agent in the treatment of liver injury induced by sepsis.

scholarly journals A study for a role of inducible NO synthase in septic rats with cecal ligation and puncture (CLP)

1999 ◽  
Vol 79 ◽  
pp. 97
Author(s):  
Masayoshi Abe ◽  
Iku Okamoto ◽  
Kazuhiko Shibata ◽  
Keiichi Tanaka ◽  
Noriyuki Sakata ◽  
...  
Keyword(s):  
Cecal Ligation ◽  
No Synthase ◽  
Cecal Ligation And Puncture ◽  
Inducible No Synthase

Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats

Shock ◽  
2009 ◽  
pp. 1 ◽  
Author(s):  
Elif Cadirci ◽  
Berrin Zuhal Altunkaynak ◽  
Zekai Halici ◽  
Fehmi Odabasoglu ◽  
M. Hamidullah Uyanik ◽  
...  
Keyword(s):  
Lung Injury ◽  
Lipoic Acid ◽  
Cecal Ligation ◽  
Alpha Lipoic Acid ◽  
Cecal Ligation And Puncture ◽  
Potential Target ◽  
Sepsis Model

scholarly journals Role of Lipopolysaccharide and Cecal Ligation and Puncture on Blood Coagulation and Inflammation in Sensitive and Resistant Mice Models

2005 ◽  
Vol 166 (4) ◽  
pp. 1089-1098 ◽  
Author(s):  
Javier Corral ◽  
José Yélamos ◽  
David Hernández-Espinosa ◽  
Yolanda Monreal ◽  
Ruben Mota ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Cecal Ligation ◽  
Cecal Ligation And Puncture

scholarly journals Volatile Anesthetics Improve Survival after Cecal Ligation and Puncture

2013 ◽  
Vol 119 (4) ◽  
pp. 901-906 ◽  
Author(s):  
Inge K. Herrmann ◽  
Maricela Castellon ◽  
David E. Schwartz ◽  
Melanie Hasler ◽  
Martin Urner ◽  
...  
Keyword(s):  
Overall Survival ◽  
Cecal Ligation ◽  
Volatile Anesthetics ◽  
Study Data ◽  
Cecal Ligation And Puncture ◽  
Immunomodulatory Effects ◽  
Organ Function ◽  
Minimal Alveolar Concentration ◽  
Sepsis Model ◽  
Sepsis Induction

Abstract Background: Sepsis remains a leading cause of death in intensive care units. There is growing evidence that volatile anesthetics have beneficial immunomodulatory effects on complex inflammation-mediated conditions. The authors investigated the effect of volatile anesthetics on the overall survival of mice in a sepsis model of cecal ligation and puncture (CLP). Methods: Mice (N = 12 per treatment group) were exposed to anesthetic concentrations of desflurane, isoflurane, and sevoflurane either during induction of sepsis or when the mice showed pronounced symptoms of inflammation. Overall survival, as well as organ function and inflammation was compared with the CLP group without intervention. Results: With desflurane and sevoflurane conditioning (1.2 minimal alveolar concentration for 2 h immediately after induction of CLP) overall survival was improved to 58% and 83%, respectively, compared with 17% in the untreated CLP group. Isoflurane did not significantly affect outcome. Application of sevoflurane 24 h after sepsis induction significantly improved overall survival to 66%. Conclusions: Administration of the volatile anesthetics desflurane and sevoflurane reduced CLP-induced mortality. Anesthesia may be a critical confounder when comparing study data where different anesthesia protocols were used.

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