scholarly journals A French multicenter randomised trial comparing two dose-regimens of prothrombin complex concentrates in urgent anticoagulation reversal

Critical Care ◽  
2013 ◽  
Vol 17 (1) ◽  
pp. R4 ◽  
Author(s):  
Delphine Kerebel ◽  
Luc-Marie Joly ◽  
Didier Honnart ◽  
Jeannot Schmidt ◽  
Damien Galanaud ◽  
...  
Keyword(s):  
Randomised Trial ◽  
Prothrombin Complex Concentrates ◽  
Anticoagulation Reversal

Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists

2011 ◽  
Vol 106 (09) ◽  
pp. 429-438 ◽  
Author(s):  
Chiara Marchesi ◽  
Matteo Pierfranceschi ◽  
Mark Crowther ◽  
David Garcia ◽  
Elaine Hylek ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Vitamin K ◽  
Meta Analysis ◽  
Vitamin K Antagonists ◽  
Total Mortality ◽  
Thromboembolic Complication ◽  
Thromboembolic Complications ◽  
Weighted Mean ◽  
Prothrombin Complex Concentrates ◽  
Anticoagulation Reversal

SummaryProthrombin complex concentrates (PCCs) are recommended as the treatment of choice in warfarin-related coagulopathy. However, the risk of thromboembolic complications associated with their use is not well defined. We performed a meta-analysis to estimate the rate of thromboembolic complications in patients receiving vitamin K antagonists (VKAs) treated with PCCs for bleeding or before urgent surgery. Medline and Embase databases were searched. Two reviewers performed study selection and extracted data independently. Studies providing data on incidence of thromboembolic complications in VKA-treated patients were eligible for the study. Weighted mean proportion of the rate of thromboembolic complications and the mortality rate were calculated. Twenty-seven studies (1,032 patients) were included. Seven studies used 3-factor, and 20 4-factor PCCs. Twelve patients had a thromboembolic complication (weighted mean 1.4%; 95% CI 0.8–2.1), of which two were fatal. The incidence of thromboembolic events was 1.8% (95% CI 1.0–3.0) in patients treated with 4-factor PCCs, and 0.7% (95% CI 0.0–2.4) in patients treated with 3-factor PCCs. Total mortality rate was 10.6% (95% CI 5.9–16.6). In conclusion, our results suggest there is a low but quantifiable risk of thromboembolism in VKA-treated patients receiving PCCs for anticoagulation reversal. These findings should be confirmed in randomised, controlled trials.

scholarly journals Utilization of anti–factor Xa levels to guide reversal of oral factor Xa inhibitors in the emergency department

2021 ◽  
Author(s):  
Anne E Zepeski ◽  
Brett A Faine ◽  
Anna E Merrill ◽  
Grerk Sutamtewagul ◽  
Sharathkumar Bhagavathi
Keyword(s):  
Emergency Department ◽  
Anticoagulation Therapy ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Prothrombin Complex Concentrates ◽  
Anticoagulation Reversal ◽  
Reversal Agents ◽  
Patient Disposition ◽  
Rule Out

Abstract Disclaimer In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose Oral factor Xa inhibitors (FXaIs) are increasingly utilized for outpatient anticoagulation therapy; however, laboratory monitoring is not routinely used to assess the safety and efficacy of these agents. We aimed to evaluate the role of chromogenic anti–factor Xa (anti-Xa) assays in the emergency department (ED) in the setting of patients with an acute bleed or requiring emergent procedures. Methods A retrospective review was completed of anti-Xa levels obtained in the ED between June 1, 2019, and April 30, 2020. Data were collected to describe the clinical setting of anti-Xa level collection, oral FXaIs used before admission, administration of reversal agents, and patient disposition to further characterize the role of anti-Xa levels in the management of rivaroxaban and apixaban reversal. Results Thirty anti-Xa levels were included in the final analysis. The median time from sample collection to anti-Xa assay result was 45.9 minutes (interquartile range, 35.3-54.7 minutes). Eleven patients (37%) received anticoagulation reversal after their anti-Xa levels were determined. Anticoagulation reversal agents included either activated prothrombin complex concentrates (aPCCs) or prothrombin complex concentrates (PCCs). Anti-Xa levels were collected in 2 patients who had received PCCs before arrival at our ED. Of the patients with anti-Xa levels below 30 ng/mL, none received aPCCs or PCCs after their anti-Xa levels were determined. Anti-Xa assays were used to rule out the presence of FXaIs in 3 patients. Conclusion This study illustrates the novel role of anti-Xa levels in managing patients with an emergent need for reversal in the ED. The assay may be used to rule out the presence of oral FXaIs and avoid unnecessary administrations of anticoagulation reversal agents.

Risk factors for suboptimal efficacy of 3-factor prothrombin complex concentrates in emergency VKA anticoagulation reversal

2014 ◽  
Vol 112 (09) ◽  
pp. 621-623 ◽  
Author(s):  
Davide Imberti ◽  
Eleonora Tamburini Permunian ◽  
Ezio Croci ◽  
Walter Ageno ◽  
Francesco Dentali
Keyword(s):  
Risk Factors ◽  
Prothrombin Complex Concentrates ◽  
Anticoagulation Reversal

scholarly journals Prothrombin Complex Concentrates for Urgent Anticoagulation Reversal in Patients with Intracranial Haemorrhage

2007 ◽  
Vol 36 (5) ◽  
pp. 259-265 ◽  
Author(s):  
D. Imberti ◽  
G. Barillari ◽  
C. Biasioli ◽  
M. Bianchi ◽  
L. Contino ◽  
...  
Keyword(s):  
Intracranial Haemorrhage ◽  
Prothrombin Complex Concentrates ◽  
Anticoagulation Reversal

scholarly journals Prothrombin complex concentrates in warfarin anticoagulation reversal

2012 ◽  
Vol 34 (4) ◽  
pp. 302-304
Author(s):  
Carolina Costa-Lima ◽  
Maiara Marx Luz Fiusa ◽  
Joyce M Annichino-Bizzacchi ◽  
Erich Vinicius de Paula
Keyword(s):  
Prothrombin Complex Concentrates ◽  
Anticoagulation Reversal
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