scholarly journals Doppler resistive index to reflect regulation of renal vascular tone during sepsis and acute kidney injury

Critical Care ◽  
2012 ◽  
Vol 16 (5) ◽  
pp. R165 ◽  
Author(s):  
Antoine Dewitte ◽  
Julien Coquin ◽  
Bertrand Meyssignac ◽  
Olivier Joannès-Boyau ◽  
Catherine Fleureau ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Vascular Tone ◽  
Resistive Index ◽  
Kidney Injury ◽  
Renal Vascular ◽  
Renal Vascular Tone

scholarly journals Doppler resistive index to reflect risk of acute kidney injury after major abdominal surgery: A prospective observational trial

2019 ◽  
Vol 63 (7) ◽  
pp. 551 ◽  
Author(s):  
Satyen Parida ◽  
Kavitha Muthukrishnan ◽  
SDeepak Barathi ◽  
AshokShankar Badhe ◽  
SandeepKumar Mishra
Keyword(s):  
Acute Kidney Injury ◽  
Abdominal Surgery ◽  
Resistive Index ◽  
Kidney Injury ◽  
Major Abdominal Surgery ◽  
Observational Trial

scholarly journals Bedside Renal Doppler Ultrasonography and Acute Kidney Injury after TAVR

2020 ◽  
Vol 9 (4) ◽  
pp. 905
Author(s):  
Marilou Peillex ◽  
Benjamin Marchandot ◽  
Sophie Bayer ◽  
Eric Prinz ◽  
Kensuke Matsushita ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Severe Aortic Stenosis ◽  
Resistive Index ◽  
Kidney Injury ◽  
Right Atrial ◽  
Renal Resistive Index ◽  
Serum Cystatin C ◽  
Systemic Hemodynamic ◽  
Dismal Prognosis ◽  
Renal Doppler

Acute kidney injury (AKI) following transcatheter aortic valve replacement (TAVR) is associated with a dismal prognosis. Elevated renal resistive index (RRI), through renal Doppler ultrasound (RDU) evaluation, has been associated with AKI development and increased systemic arterial stiffness. Our pilot study aimed to investigate the performance of Doppler based RRI to predict AKI and outcomes in TAVR patients. From May 2018 to May 2019, 100 patients with severe aortic stenosis were prospectively enrolled for TAVR and concomitant RDU evaluation at our institution (Nouvel Hôpital Civil, Strasbourg University, France). AKI by serum Creatinine (sCr-AKI) was defined according to the VARC-2 definition and AKI by serum Cystatin C (sCyC-AKI) was defined as an sCyC increase of greater than 15% with baseline value. Concomitant RRI measurements as well as renal and systemic hemodynamic parameters were recorded before, one day, and three days after TAVR. It was found that 10% of patients presented with AKIsCr and AKIsCyC. The whole cohort showed higher baseline RRI values (0.76 ± 0.7) compared to normal known and accepted values. AKIsCyC had significant higher post-procedural RRI one day (Day 1) after TAVR (0.83 ± 0.1 vs. 0.77 ± 0.6, CI 95%, p = 0.005). AUC for AKIsCyC was 0.766 and a RRI cut-off value of ≥ 0.795 had the most optimal sensitivity/specificity (80/62%) combination. By univariate Cox analysis, Mehran Risk Score, higher baseline right atrial pressure at baseline >0.8 RRI values one day after TAVR (HR 6.5 (95% CI 1.3–32.9; p = 0.021) but not RRI at baseline were significant predictors of AKIsCyC. Importantly, no significant impact of baseline biological parameters, renal or systemic parameters could be demonstrated. Doppler-based RRI can be helpful for the non-invasive assessment of AKI development after TAVR.

scholarly journals SP171THE SYNTHETIC TIE2 AGONIST VASCULOTIDE PROTECTS RENAL VASCULAR BARRIER FUNCTION IN ISCHEMIC ACUTE KIDNEY INJURY

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i144-i144
Author(s):  
Eva Rübig ◽  
Daniel J Dumont ◽  
Paul van Slyke ◽  
Jörg Stypmann ◽  
Alexander Lukasz ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Barrier Function ◽  
Kidney Injury ◽  
Ischemic Acute Kidney Injury ◽  
Renal Vascular

Semiquantitative Power Doppler Ultrasound Score to Predict Acute Kidney Injury in Patients With Sepsis or Cardiac Failure: A Prospective Observational Study

2019 ◽  
Vol 36 (1) ◽  
pp. 115-122 ◽  
Author(s):  
Hai Jun Zhi ◽  
Jing Zhao ◽  
Shen Nie ◽  
Yun Jie Ma ◽  
Xiao Ya Cui ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Doppler Ultrasound ◽  
Cardiac Failure ◽  
Power Doppler ◽  
Resistive Index ◽  
Kidney Injury ◽  
Renal Resistive Index ◽  
Power Doppler Ultrasound ◽  
Predictive Values ◽  
Ultrasound Score

Background: Diagnosing acute kidney injury (AKI) stage 3 in critically ill patients may help physicians in making treatment decisions. This diagnosis relies chiefly on urinary output and serum creatinine, which may be of limited value. This study aimed to explore the diagnostic performance of renal resistive index (RRI) and semiquantitative power Doppler ultrasound (PDU) scores in predicting AKI stage 3 in patients with sepsis or cardiac failure. Methods: This study is a prospective observational study that included 83 patients (40 with sepsis and 43 with cardiac failure). Renal resistive index and semiquantitative PDU scores were measured within 6 hours following admission to the intensive care unit. Acute kidney injury was defined according to the criteria set by Kidney Disease Improving Global Outcomes. Results: The predictive values of RRI (area under the curve [AUC] = 0.772, 95% confidence interval [CI] = 0.658-0.886) and PDU score (AUC = 0.780, 95% CI = 0.667-0.892) were similar in all patients. Power Doppler ultrasound score (AUC = 0.910, 95% CI = 0.815-1.000) could effectively predict AKI stage 3 in the cardiac failure subgroup, and the optimal cutoff for this parameter was ≤ 1 (sensitivity = 87.5%, specificity = 92.6%, Youden index = 0.801, accuracy in our population = 90.7%). However, PDU scores (AUC = 0.620, 95% CI = 0.425-0.814) could not predict AKI stage 3 in the sepsis subgroup. The predictive values of RRI for AKI stage 3 in the cardiac failure (AUC = 0.820, 95% CI = 0.666-0.974) and sepsis (AUC = 0.724, 95% CI = 0.538-0.910) subgroups were similar. Conclusions: Power Doppler ultrasound scores could effectively predict AKI stage 3 in patients with cardiac failure but not in patients with sepsis. Renal resistive index is a poor predictor of AKI stage 3 in patients with sepsis or cardiac failure.

Stimulation of renin release by prostaglandin E2 is mediated by EP2 and EP4 receptors in mouse kidneys

2004 ◽  
Vol 287 (3) ◽  
pp. F427-F433 ◽  
Author(s):  
Frank Schweda ◽  
Jürgen Klar ◽  
Shuh Narumiya ◽  
Rolf M. Nüsing ◽  
Armin Kurtz
Keyword(s):  
Vascular Tone ◽  
Threshold Concentration ◽  
Renin Release ◽  
Receptor Subtypes ◽  
Wild Type ◽  
Adrenoceptor Agonist ◽  
Functional Relevance ◽  
Renal Vascular ◽  
Renal Vascular Tone ◽  
Stimulation Of

PGE2 is a potent stimulator of renin release. So far, the contribution of each of the four PGE2 receptor subtypes (EP1–EP4) in the regulation of renin release has not been characterized. Therefore, we investigated the effects PGE2 on renin secretion rates (RSR) from isolated, perfused kidneys of EP1−/−, EP2−/−, EP3−/−, EP4−/−, and wild-type mice. PGE2 concentration dependently stimulated RSR from kidneys of all four knockout strains with a threshold concentration of 1 nM in EP1−/−, EP2−/−, EP3−/−, and wild-type mice, whereas the threshold concentration was shifted to 10 nM in EP4−/− mice. Moreover, the maximum stimulation of RSR by PGE2 at 1 μM was significantly reduced in EP4−/− (12.8-fold of control) and EP2−/− (15.9-fold) compared with wild-type (20.7-fold), EP1−/− (23.8-fold), and EP3−/− (20.1-fold). In contrast, stimulation of RSR by either the loop diuretic bumetanide or the β-adrenoceptor agonist isoproterenol was similar in all strains. PGE2 exerted a dual effect on renal vascular tone, inducing vasodilatation at low concentrations (1 nmol/) and vasoconstriction at higher concentrations (100 nmol/) in kidneys of wild-type mice. In kidneys of EP2−/− as well as EP4−/− mice, vasodilatation at low PGE2 concentrations was prevented, whereas vasoconstriction at higher concentrations was augmented. In contrast, the vasodilatatory component was pronounced in kidneys of EP1 and EP3 knockout mice, whereas in both genotypes the vasoconstriction at higher PGE2 concentrations was markedly blunted. Our data provide evidence that PGE2 stimulates renin release via activation of EP2 and EP4 receptors, whereas EP1 and EP3 receptors appear to be without functional relevance in juxtaglomerular cells. In contrast, all four receptor subtypes are involved in the control of renal vascular tone, EP1 and EP3 receptors increasing, and EP2 as well as EP4 receptors, decreasing it.

scholarly journals Intraoperative renal resistive index threshold as an acute kidney injury biomarker

2020 ◽  
Vol 61 ◽  
pp. 109626 ◽  
Author(s):  
Anne D. Cherry ◽  
Jennifer N. Hauck ◽  
Benjamin Y. Andrew ◽  
Yi-Ju Li ◽  
Jamie R. Privratsky ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Resistive Index ◽  
Kidney Injury ◽  
Renal Resistive Index
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