scholarly journals Long-term adverse neuropsychological functioning in children who survived meningococcal septic shock: is there a relationship with sedation and analgesia during paediatric ICU admission?

Critical Care ◽  
2012 ◽  
Vol 16 (S1) ◽  
Author(s):  
HL Van Zellem ◽  
E Utens ◽  
SN De Wildt ◽  
WC Hop ◽  
NJ Vet ◽  
...  
Keyword(s):  
Septic Shock ◽  
Neuropsychological Functioning ◽  
Icu Admission ◽  
Meningococcal Septic Shock ◽  
Sedation And Analgesia

scholarly journals Long-term Health Status in Childhood Survivors of Meningococcal Septic Shock

2008 ◽  
Vol 162 (11) ◽  
pp. 1036 ◽  
Author(s):  
Corinne M. P. Buysse ◽  
Hein Raat ◽  
Jan A. Hazelzet ◽  
Jessie M. Hulst ◽  
Karlien Cransberg ◽  
...  
Keyword(s):  
Septic Shock ◽  
Health Status ◽  
Meningococcal Septic Shock ◽  
Childhood Survivors

scholarly journals Improved Survival beyond 28 Days up to 1 Year after CytoSorb Treatment for Refractory Septic Shock: A Propensity-Weighted Retrospective Survival Analysis

2020 ◽  
pp. 1-7
Author(s):  
Willem P. Brouwer ◽  
Servet Duran ◽  
Can Ince
Keyword(s):  
Septic Shock ◽  
Positive Predictive Value ◽  
Predictive Value ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Factors Associated ◽  
Icu Admission ◽  
Lactate Levels

<b><i>Background and Aims:</i></b> It is currently unknown whether CytoSorb treatment for septic shock improves long-term survival beyond 28 days from intensive care unit (ICU) admission and which factors determine outcome. <b><i>Methods:</i></b> This was a long-term follow-up retrospective analysis of patients with septic shock who were treated with continuous renal replacement therapy (CRRT) + CytoSorb (<i>n</i> = 67) or CRRT alone (<i>n</i> = 49). These patients were previously analyzed for 28-day mortality. The primary outcome was the time to long-term all-cause mortality. Factors associated with time to event were analyzed both weighted by stabilized inverse probability of treatment weights (sIPTW) as well as unweighted stratified by therapy received. <b><i>Results:</i></b> The median follow-up for the total cohort was 30 days (interquartile range [IQR]: 5–334, maximum 1,059 days) after ICU admission and 333 days (IQR: 170–583) for those who survived beyond 28 days (<i>n</i> = 59). Survival beyond 28 days was sustained up to 1 year after ICU admission for both treatment regimens: 80% (standard error [SE] 7%) vs. 87% (SE 7%), for CytoSorb vs. CRRT, respectively, <i>p</i> = 0.853. By sIPTW, CytoSorb was significantly associated with long-term outcome compared to CRRT (adjusted hazard ratio [aHR] 0.59, 95% confidence interval [CI] 0.37–0.93, <i>p</i> = 0.025). Independent factors associated with long-term outcome in CytoSorb-treated patients were baseline log<sub>10</sub> lactate levels (aHR 5.1, <i>p</i> = 0.002), age in the presence of comorbidity (aHR 2.60, <i>p</i> = 0.013), and presence of abdominal sepsis (aHR 0.34, <i>p</i> = 0.004). A lactate level above 6.0 mmol/L at the start of CytoSorb therapy had a positive predictive value of 79% for mortality (<i>p</i> = 0.013). <b><i>Conclusions:</i></b> Survival is achieved with CytoSorb and CRRT for patients with septic shock beyond 28 days from ICU admission and may be improved for CytoSorb treatment. Lactate levels above 6.0 mmol/L at the start of CytoSorb therapy are predictive of worse outcome with high specificity and positive predictive value.

scholarly journals Surviving meningococcal septic shock in childhood: long-term overall outcome and the effect on health-related quality of life

Critical Care ◽  
2010 ◽  
Vol 14 (3) ◽  
pp. R124 ◽  
Author(s):  
Corinne MP Buysse ◽  
Lindy CAC Vermunt ◽  
Hein Raat ◽  
Jan A Hazelzet ◽  
Wim CJ Hop ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Septic Shock ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Meningococcal Septic Shock

Long-term skin scarring and orthopaedic sequelae in survivors of meningococcal septic shock

2009 ◽  
Vol 94 (5) ◽  
pp. 381-386 ◽  
Author(s):  
C M P Buysse ◽  
A P Oranje ◽  
E Zuidema ◽  
J A Hazelzet ◽  
W C J Hop ◽  
...  
Keyword(s):  
Septic Shock ◽  
Meningococcal Septic Shock

Long-term health-related quality of life in survivors of meningococcal septic shock in childhood and their parents

2007 ◽  
Vol 16 (10) ◽  
pp. 1567-1576 ◽  
Author(s):  
Corinne M. P. Buysse ◽  
Hein Raat ◽  
Jan A. Hazelzet ◽  
Lindy C. A. C. Vermunt ◽  
Elisabeth M. W. J. Utens ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Septic Shock ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Meningococcal Septic Shock

scholarly journals Persistently higher serum sCD40L levels are associated with outcome in septic patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yingjian Liang ◽  
Chengrui Zhu ◽  
Yini Sun ◽  
Zhiliang Li ◽  
Liang Wang ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Septic Shock ◽  
Odds Ratio ◽  
Cd40 Ligand ◽  
Surgical Patients ◽  
Soluble Cd40 Ligand ◽  
Icu Admission ◽  
Time Changes ◽  
And Control ◽  
Type Of Surgery

Abstract Background Soluble CD40 ligand (sCD40L) exhibits proinflammatory and procoagulant effects. Recent data indicated that sCD40L plays a significant role in septic patients. The aim of the present study was to determine sCD40L changes in surgical patients without sepsis (SWS) and surgical sepsis patients (SS) during the first 3 days after intensive care unit (ICU) admission and to observe the association between sCD40L and mortality. Methods Time changes in sCD40L levels were assessed for 3 days after ICU admission in 49 patients with SS and compared with those in 19 SWS patients. Serum sCD40L concentration was detected by ELISA. Survival at 28 days served as the endpoint. Results SS had significantly higher sCD40L levels than SWS and control patients. We observed an association between sCD40L levels ≥1028.75 pg/mL at day 2 and 28-day mortality (odds ratio = 7.888; 95% confidence interval = 1.758 to 35.395; P = 0.007). We could not discover any significant differences in sex, presence of septic shock, site of infection, length of stay in the ICU, PaO2/FiO2 ratio, incidence of AKI, ARDS, or type of surgery between nonsurvivors and survivors. Conclusions Septic patients show persistently higher circulating sCD40L levels in the first 3 days after ICU admission, and serum sCD40L levels are associated with the mortality of patients with sepsis. Thus, serum sCD40L may be used as a reliable biomarker and therapeutic target in sepsis.

scholarly journals Healthcare trajectories before and after critical illness: population-based insight on diverse patients clusters

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Youenn Jouan ◽  
Leslie Grammatico-Guillon ◽  
Noémie Teixera ◽  
Claire Hassen-Khodja ◽  
Christophe Gaborit ◽  
...  
Keyword(s):  
Septic Shock ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Critical Illness ◽  
Length Of Stay ◽  
Population Based ◽  
Hospital Length Of Stay ◽  
Healthcare Use ◽  
Icu Admission ◽  
Icu Discharge

Abstract Background The post intensive care syndrome (PICS) gathers various disabilities, associated with a substantial healthcare use. However, patients’ comorbidities and active medical conditions prior to intensive care unit (ICU) admission may partly drive healthcare use after ICU discharge. To better understand retative contribution of critical illness and PICS—compared to pre-existing comorbidities—as potential determinant of post-critical illness healthcare use, we conducted a population-based evaluation of patients’ healthcare use trajectories. Results Using discharge databases in a 2.5-million-people region in France, we retrieved, over 3 years, all adult patients admitted in ICU for septic shock or acute respiratory distress syndrome (ARDS), intubated at least 5 days and discharged alive from hospital: 882 patients were included. Median duration of mechanical ventilation was 11 days (interquartile ranges [IQR] 8;20), mean SAPS2 was 49, and median hospital length of stay was 42 days (IQR 29;64). Healthcare use (days spent in healthcare facilities) was analyzed 2 years before and 2 years after ICU admission. Prior to ICU admission, we observed, at the scale of the whole study population, a progressive increase in healthcare use. Healthcare trajectories were then explored at individual level, and patients were assembled according to their individual pre-ICU healthcare use trajectory by clusterization with the K-Means method. Interestingly, this revealed diverse trajectories, identifying patients with elevated and increasing healthcare use (n = 126), and two main groups with low (n = 476) or no (n = 251) pre-ICU healthcare use. In ICU, however, SAPS2, duration of mechanical ventilation and length of stay were not different across the groups. Analysis of post-ICU healthcare trajectories for each group revealed that patients with low or no pre-ICU healthcare (which represented 83% of the population) switched to a persistent and elevated healthcare use during the 2 years post-ICU. Conclusion For 83% of ARDS/septic shock survivors, critical illness appears to have a pivotal role in healthcare trajectories, with a switch from a low and stable healthcare use prior to ICU to a sustained higher healthcare recourse 2 years after ICU discharge. This underpins the hypothesis of long-term critical illness and PICS-related quantifiable consequences in healthcare use, measurable at a population level.

LEVELS OF APC, S-PROTEIN C RECEPTOR AND THROMBOMODULIN IN MENINGOCOCCAL SEPTIC SHOCK ARE RELATED TO SURVIVAL.

Shock ◽  
2001 ◽  
Vol 15 (Supplement) ◽  
pp. 55-56
Author(s):  
J A Hazelzet ◽  
E D de Kleijn ◽  
R de Groot ◽  
D. J. Stearns-Kurosawa ◽  
Shinichiro Kurosawa ◽  
...  
Keyword(s):  
Septic Shock ◽  
Protein C ◽  
S Protein ◽  
Meningococcal Septic Shock

Predicting value of prehospital body temperature for ICU admission of septic shock patients

2019 ◽  
Vol 18 (1) ◽  
pp. 56-58
Author(s):  
Romain Jouffroy ◽  
◽  
Anastasia Saade ◽  
Stephane Durand ◽  
Pascal Philippe ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Septic Shock ◽  
Body Temperature ◽  
Propensity Score Analysis ◽  
Call Centre ◽  
Icu Patients ◽  
Icu Admission ◽  
Score Analysis ◽  
The Mean ◽  
Proper Orientation

To specify whether an association exists between pre-hospital body temperature collected by the emergency medical services (EMS) call centre, and intensive care unit (ICU) admission of patients with septic shock. An observational study based on data collected by the EMS of Paris. All septic shocks were included. Among, the 140 calls concerning septic shock, 22 patients (16%) were admitted to ICU. The mean core temperature was 37.4±1.6°C for ICU and 38.6±1.1°C (p<4.10^-5) for non-ICU patients. Using propensity score analysis, the relative risk for ICU admission of patients with pre-hospital fever or hypothermia was 0.31 and 2 respectively. The study highlights the potential usefulness of early temperature measurement in septic shock patients to allow early proper orientation.

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