scholarly journals Risk factors for poor outcome in patients with osmotic demyelination syndrome

Critical Care ◽  
2012 ◽  
Vol 16 (S1) ◽  
Author(s):  
MA Peters ◽  
JG Van der Hoeven ◽  
C Hoedemaekers
Keyword(s):  
Risk Factors ◽  
Osmotic Demyelination Syndrome ◽  
Poor Outcome ◽  
Osmotic Demyelination

scholarly journals Osmotic Demyelination Syndrome Following Correction of Hyponatremia by ≤10 mEq/L per day

Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0004402021
Author(s):  
Srijan Tandukar ◽  
Richard H. Sterns ◽  
Helbert Rondon-Berrios
Keyword(s):  
Risk Factors ◽  
Serum Sodium ◽  
Alcohol Use Disorder ◽  
Neurological Deficits ◽  
Osmotic Demyelination Syndrome ◽  
European Guidelines ◽  
Osmotic Demyelination ◽  
Chronic Hyponatremia ◽  
The Mean ◽  
Sodium Correction

Background: Overly rapid correction of chronic hyponatremia may lead to osmotic demyelination syndrome. European guidelines recommend a correction to ≤10 mEq/L in 24 hours to prevent this complication. However, osmotic demyelination syndrome may occur despite adherence to these guidelines. Methods: We searched the literature for reports of osmotic demyelination syndrome with rates of correction of hyponatremia <10 mEq/L in 24 hours. The reports were reviewed to identify specific risk factors for this complication. Results: We identified 19 publications with a total of 21 patients that were included in our analysis. The mean age was 52 years of which 67% were male. All of the patients had community acquired chronic hyponatremia. Twelve patients had an initial serum sodium <115 mEq/L, of which seven had an initial serum sodium ≤105 mEq/L. Other risk factors identified included alcohol use disorder (n=11), hypokalemia (n=5), liver disease (n=6), and malnutrition (n=11). The maximum rate of correction in patients with serum sodium <115 mEq/L was at least 8 mEq/L in all but 1 patient. In contrast, correction was <8 mEq/L in all but 2 patients with serum sodium >115 mEq/L. Among the latter group, osmotic demyelination syndrome developed before hospital admission or was unrelated to hyponatremia overcorrection. Four patients died (19%), 5 had full recovery (24%) and 9 (42%) had varying degrees of residual neurological deficits. Conclusions: Osmotic demyelination syndrome can occur in patients with chronic hyponatremia with a serum sodium <115 mEq/L despite rates of serum sodium correction <10 mEq/L in 24 hours. In patients with severe hyponatremia and high risk features, especially those with serum sodium <115 mEq/L, we recommend limiting serum sodium correction to <8 mEq/L. Thiamine supplementation is advisable for any hyponatremic patient whose dietary intake has been poor.

scholarly journals Role of Risk Factors in Developing Osmotic Demyelination Syndrome During Correction of Hyponatremia: A Case Study

Cureus ◽  
2020 ◽  
Author(s):  
Tom D.Y. Reijnders ◽  
Wilbert M.T. Janssen ◽  
S.M. Laila Niamut ◽  
Andrea B Kramer
Keyword(s):  
Risk Factors ◽  
Osmotic Demyelination Syndrome ◽  
Osmotic Demyelination

scholarly journals Osmotic Demyelination Syndrome in a Patient with Hypokalemia but No Hyponatremia

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Carolina Ormonde ◽  
Raquel Cabral ◽  
Sara Serpa
Keyword(s):  
Risk Factors ◽  
Central Nervous System ◽  
Nervous System ◽  
Rare Case ◽  
Rapid Rise ◽  
Osmotic Demyelination Syndrome ◽  
Multiple Risk Factors ◽  
Osmotic Demyelination ◽  
The Central Nervous System ◽  
Rapid Correction

Osmotic demyelination syndrome (ODS) is characterized by loss of myelin in various parts of the central nervous system. It is mainly caused by a rapid correction of hyponatremia, although other factors that may cause rapid rise in serum osmolality can also be associated with its development. Its prognosis is poor and the recovery rate is unknown. The authors report a rare case of a patient with multiple risk factors for ODS, without hyponatremia, who developed ODS and surprisingly recovered. This case report highlights the importance of recognizing risk factors for the development of ODS, even if the main one is not present.

scholarly journals A case of Osmotic demyelination syndrome despite normal rate of Sodium correction with good recovery

2018 ◽  
Vol 17 (3) ◽  
pp. 160-163
Author(s):  
Shiva Mongolu ◽  
Keyword(s):  
Risk Factors ◽  
Sodium Concentration ◽  
Good Recovery ◽  
Osmotic Demyelination Syndrome ◽  
Good Clinical Outcome ◽  
Osmotic Demyelination ◽  
Severe Hyponatraemia ◽  
Sodium Correction ◽  
Hospital Inpatients ◽  
Rapid Correction

The Osmotic demyelination syndrome (ODS) primarily occurs with rapid correction of severe hyponatraemia that has been present for more than two or three days. Some patients are, however at risk and can develop ODS at higher sodium concentration and lower rates of correction. A case of Osmotic demyelination Syndrome which developed despite an ‘optimal’ rate of correction of serum Sodium with good clinical outcome is described. The risk factors that contribute to development of ODS and strategies to prevent this complication are discussed, along with recommendations on how to manage this condition in hospital inpatients.

Risk factors for poor outcome after ECMO treatment of low cardiac output after cardiac surgery

2007 ◽  
Vol 55 (S 1) ◽  
Author(s):  
S Deiters ◽  
H Welp ◽  
J Graf ◽  
A Löher ◽  
S Schneider ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiac Output ◽  
Cardiac Surgery ◽  
Low Cardiac Output ◽  
Poor Outcome ◽  
Ecmo Treatment

scholarly journals A-126 Clinical Utility of Risk Factors to Predict Self-reported Neurobehavioral Outcome Following Traumatic Brain Injury: PTSD, Sleep, Resilience, and Lifetime Blast Exposure

2020 ◽  
Vol 35 (6) ◽  
pp. 919-919
Author(s):  
Lange R ◽  
Lippa S ◽  
Hungerford L ◽  
Bailie J ◽  
French L ◽  
...  
Keyword(s):  
Risk Factors ◽  
Traumatic Brain Injury ◽  
Risk Factor ◽  
Brain Injury ◽  
Clinical Utility ◽  
Poor Sleep ◽  
Post Injury ◽  
Poor Outcome ◽  
Blast Exposure ◽  
Neurobehavioral Outcome

Abstract Objective To examine the clinical utility of PTSD, Sleep, Resilience, and Lifetime Blast Exposure as ‘Risk Factors’ for predicting poor neurobehavioral outcome following traumatic brain injury (TBI). Methods Participants were 993 service members/veterans evaluated following an uncomplicated mild TBI (MTBI), moderate–severe TBI (ModSevTBI), or injury without TBI (Injured Controls; IC); divided into three cohorts: (1) &lt; 12 months post-injury, n = 237 [107 MTBI, 71 ModSevTBI, 59 IC]; (2) 3-years post-injury, n = 370 [162 MTBI, 80 ModSevTBI, 128 IC]; and (3) 10-years post-injury, n = 386 [182 MTBI, 85 ModSevTBI, 119 IC]. Participants completed a 2-hour neurobehavioral test battery. Odds Ratios (OR) were calculated to determine whether the ‘Risk Factors’ could predict ‘Poor Outcome’ in each cohort separately. Sixteen Risk Factors were examined using all possible combinations of the four risk factor variables. Poor Outcome was defined as three or more low scores (&lt; 1SD) on five TBI-QOL scales (e.g., Fatigue, Depression). Results In all cohorts, the vast majority of risk factor combinations resulted in ORs that were ‘clinically meaningful’ (ORs &gt; 3.00; range = 3.15 to 32.63, all p’s &lt; .001). Risk factor combinations with the highest ORs in each cohort were PTSD (Cohort 1 & 2, ORs = 17.76 and 25.31), PTSD+Sleep (Cohort 1 & 2, ORs = 18.44 and 21.18), PTSD+Sleep+Resilience (Cohort 1, 2, & 3, ORs = 13.56, 14.04, and 20.08), Resilience (Cohort 3, OR = 32.63), and PTSD+Resilience (Cohort 3, OR = 24.74). Conclusions Singularly, or in combination, PTSD, Poor Sleep, and Low Resilience were strong predictors of poor outcome following TBI of all severities and injury without TBI. These variables may be valuable risk factors for targeted early interventions following injury.

scholarly journals A primary cilium in oligodendrocytes: a fine structure signal of repairs in thalamic Osmotic Demyelination Syndrome (ODS)

2021 ◽  
pp. 1-30
Author(s):  
Jacques Gilloteaux ◽  
Joanna Bouchat ◽  
Valery Bielarz ◽  
Jean-Pierre Brion ◽  
Charles Nicaise
Keyword(s):  
Fine Structure ◽  
Primary Cilium ◽  
Osmotic Demyelination Syndrome ◽  
Osmotic Demyelination

Osmotic demyelination syndrome in patients with non-Hodgkin lymphoma: A case report and literature review

2021 ◽  
pp. 1-6
Author(s):  
Miguel García-Grimshaw ◽  
Amado Jiménez-Ruiz ◽  
José Luis Ruiz-Sandoval ◽  
Carlos Cantú-Brito ◽  
Erwin Chiquete
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Hodgkin Lymphoma ◽  
Osmotic Demyelination Syndrome ◽  
Non Hodgkin Lymphoma ◽  
Osmotic Demyelination
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