scholarly journals Adrenomedullin blockade improves catecholamine responsiveness and kidney function in resuscitated murine septic shock

Critical Care ◽  
2012 ◽  
Vol 16 (S1) ◽  
Author(s):  
K Wagner ◽  
U Wachter ◽  
J Vogt ◽  
S Weber ◽  
M Groeger ◽  
...  
Keyword(s):  
Septic Shock ◽  
Kidney Function ◽  
Catecholamine Responsiveness

scholarly journals Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock

2013 ◽  
Vol 1 (1) ◽  
pp. 2 ◽  
Author(s):  
Katja Wagner ◽  
Ulrich Wachter ◽  
Josef A Vogt ◽  
Angelika Scheuerle ◽  
Oscar McCook ◽  
...  
Keyword(s):  
Septic Shock ◽  
Kidney Function ◽  
Catecholamine Responsiveness

scholarly journals The Impact of The [TIMP-2] × [IGFBP7]-Guided Checklist for Early Recognition and Treatment of Acute Illness on The Prevention of Acute Kidney Injury In Patients With Septic Shock

2021 ◽  
Author(s):  
Jingjing Wang ◽  
Jing Li ◽  
Dongqiang Wang ◽  
Yongqiang Wang ◽  
Lin Dou ◽  
...  
Keyword(s):  
Septic Shock ◽  
Mechanical Ventilation ◽  
Acute Kidney Injury ◽  
Length Of Stay ◽  
Kidney Function ◽  
Early Recognition ◽  
Kidney Injury ◽  
Acute Illness ◽  
Lower Proportion ◽  
Icu Length Of Stay

Abstract Background: Sepsis is the main aetiology of acute kidney injury (AKI) in critically ill patients, with high morbidity and mortality. The early identification of septic patients at high risk for AKI, followed by the timely implementation of appropriate interventions, is crucial for improving patient outcomes. Tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 ([TIMP-2] × [IGFBP7]) are promising biomarkers for AKI. Furthermore, the Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN) is a tool for evaluating and treating acute illness in a timely manner based on best practices. We hypothesized that the use of this biomarker-guided point-of-care tool would improve the prognosis of patients with sepsis-associated acute kidney injury (SA-AKI).Methods: This was a single-centre prospective before-and-after study in the ICU of a comprehensive tertiary hospital. From June 2015 to December 2020, we assessed and managed patients with septic shock based on the biomarker-guided CERTAIN checklist. A checklist based on the Sepsis 3.0 bundle and urinary [TIMP-2] × [IGFBP7]>0.3(ng/mL)2/1000 within 12 hours were used as the inclusion criteria. The CERTAIN checklist includes the care bundles recommended in the Sepsis 3.0 bundle and Kidney Disease: Improving Global Outcomes (KDIGO) 2012 guidelines. The primary outcome was the incidence of moderate-to-severe AKI on the first day and within seven days after enrolment and mortality at 90 days after discharge from the hospital. The secondary outcomes were the ICU length of stay, non-mechanical ventilation duration, and the proportions of patients with the recovery of renal function and major adverse kidney events (MAKEs) at 90 days after exposure to events initiating AKI.Results: At the end of the study, 124 patients had been treated based on the checklist. When compared to a cohort of 112 patients matched for disease, the CERTAIN group had a lower proportion of patients needing mechanical ventilation, a lower proportion of patients needing vasoactive agents, a shorter ICU length of stay, and a higher proportion of patients with recovered kidney function. Furthermore, there was a trend towards a higher 90-day survival rate in the CERTAIN group.Conclusions: Implementation of the CERTAIN checklist was associated with improvements in the short-term recovery of kidney function, airway and haemodynamic management and mortality in patients with SA-AKI.Trial registration: NCT01973829; Date of registration: November 1, 2013.

1468: THE EFFECTS OF BALANCED FLUID VERSUS SALINE ON KIDNEY FUNCTION IN SEPTIC SHOCK PATIENTS

2018 ◽  
Vol 46 (1) ◽  
pp. 718-718 ◽  
Author(s):  
Jingyuan Xu ◽  
Xu Liu ◽  
Yi Yang ◽  
Haibo Qiu
Keyword(s):  
Septic Shock ◽  
Kidney Function

scholarly journals TO013ADSORPTION THERAPY AND SEPTIC SHOCK: A RETROSPECTIVE STUDY COMPARING COUPLED PLASMA FILTRATION-ADSORPTION AND CYTOSORB

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Vittorio Di Maso ◽  
Domenico Grecò ◽  
Martina Cozzi ◽  
Elisa Bedina ◽  
Ugo Gerini ◽  
...  
Keyword(s):  
Septic Shock ◽  
Observational Study ◽  
Kidney Function ◽  
Sofa Score ◽  
Pressure Ratio ◽  
Complete Recovery ◽  
Post Treatment ◽  
Retrospective Observational Study ◽  
Renal Outcome ◽  
Plasma Filtration

Abstract Background and Aims Septic shock is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Excessive release of cytokines and other inflammatory mediators is a key mechanism and cytokines adsorption therapies are applied in this context to restore a balanced immune homeostasis. Different adsorption techniques are available but there are no studies comparing these different adsorption approaches. The aim of this retrospective observational study was to compare Coupled Plasma Filtration Adsorption (CPFA) and CytoSorbTM in terms of hemodynamic and clinical response, mortality and renal function recovery. Method A retrospective observational study was designed enrolling all patients admitted to ICU with a diagnosis of septic shock treated with blood adsorption, either CPFA or CytoSorbTM, from January 2015 to December 2017. Primary endpoints of the study were the assessment of changes in NE dosage, MAP values, SOFA score and PCT levels before and after blood adsorption. Secondary endpoints ICU length of stay (LOS), mortality at 30, 60 and 90 days from adsorption initiation; renal outcome at 30 and 90 days from adsorption initiation. Results The study included 28 patients (14 CPFA, 14 CytosorbTM). Adsorption treatment was associated with a significant (p=0.03) improvement in hemodynamics with a Norepinephrine/Mean Arterial Pressure ratio (NE/MAP) of 0.64 (0.14-2.6) pre-treatment vs 0.11 (0.0-0.32) post-treatment regardless of the applied technique. Furthermore, a significant (p<0.001) procalcitonin (PCT) post treatment reduction was demonstrated with a comparable effect in the two groups (p=0.32) (Fig.1). No difference has been found in SOFA score changes (p=0.06) and again without any difference between groups (p=0.17). Overall Survival (OS) rate at 30 days was comparable between groups being 64.3% in CPFA and 78.6% in CytoSorbTM group (p=0.34). Finally, a complete recovery of kidney function at 30 and 90 days has been obtained in respectively 90% and 100% of survived patients without any difference between groups (p=1.00) (Fig.2). Conclusion These data confirmed the effectiveness of adsorption in terms of short-term clinical improvement independently from the applied technique, supporting the role of both these adjunctive therapies in septic shock treatment. CPFA and CytosorbTM have comparable effects in terms of hemodynamic improvement, clinical outcome, mortality and recovery of kidney function from septic shock AKI.

Inpatient Kidney Function Recovery among Septic Shock Patients Who Initiated Kidney Replacement Therapy in the Hospital

Nephron ◽  
2020 ◽  
Vol 144 (8) ◽  
pp. 363-371
Author(s):  
Joy C.Y. Chen ◽  
Bo Hu ◽  
Ryan D. Frank ◽  
Kianoush B. Kashani
Keyword(s):  
Septic Shock ◽  
Replacement Therapy ◽  
Kidney Function ◽  
Function Recovery ◽  
Kidney Replacement Therapy

The relationship of intravenous fluid chloride content to kidney function in patients with severe sepsis or septic shock

2015 ◽  
Vol 33 (3) ◽  
pp. 439-443 ◽  
Author(s):  
Faheem W. Guirgis ◽  
Deborah J. Williams ◽  
Matthew Hale ◽  
Abubakr A. Bajwa ◽  
Adil Shujaat ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Kidney Function ◽  
Chloride Content ◽  
Intravenous Fluid ◽  
Relationship Of ◽  
The Relationship

Benefical effects of low-dose dexamethasone on cardiovascular and kidney function in septic shock in the rat are not related to iNOS inhibition

2007 ◽  
Vol 24 (Supplement 39) ◽  
pp. 153
Author(s):  
T. Johannes ◽  
E. G. Mik ◽  
H. -J. Dieterich ◽  
K. E. Unertl ◽  
C. Ince
Keyword(s):  
Septic Shock ◽  
Kidney Function ◽  
Low Dose ◽  
Inos Inhibition
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