scholarly journals High dose intravenous clonidine is superior to intravenous clomethiazole in severe alcohol withdrawal syndrome (delirium tremens)

Critical Care ◽  
10.1186/cc100 ◽  
1997 ◽  
Vol 1 (Suppl 1) ◽  
pp. P133
Author(s):  
W Sehnert ◽  
HM Brecht ◽  
FG Nowak
Keyword(s):  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Delirium Tremens ◽  
Alcohol Withdrawal Syndrome ◽  
High Dose

P0227 RISK FACTORS FOR DELIRIUM TREMENS IN PATIENTS WITH ALCOHOL WITHDRAWAL SYNDROME IN A HOSPITAL SETTING

2009 ◽  
Vol 20 ◽  
pp. S81
Author(s):  
Rafael Monte ◽  
Ramón Rabuñal ◽  
Milagros Peña ◽  
Hugo López ◽  
Ana Pazos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Delirium Tremens ◽  
Hospital Setting ◽  
Alcohol Withdrawal Syndrome

Alcohol Withdrawal Syndrome in Critically Ill Patients: Identification, Assessment, and Management

2016 ◽  
Vol 36 (1) ◽  
pp. 28-38 ◽  
Author(s):  
Lynsey J. Sutton ◽  
Annemarie Jutel
Keyword(s):  
At Risk ◽  
Alcohol Consumption ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Delirium Tremens ◽  
Alcohol Withdrawal Syndrome ◽  
Rapid Identification ◽  
Severe Withdrawal

Management of alcohol withdrawal in critically ill patients is a challenge. The alcohol consumption histories of intensive care patients are often incomplete, limiting identification of patients with alcohol use disorders. Abrupt cessation of alcohol places these patients at risk for alcohol withdrawal syndrome. Typically benzodiazepines are used as first-line therapy to manage alcohol withdrawal. However, if patients progress to more severe withdrawal or delirium tremens, extra adjunctive medications in addition to benzodiazepines may be required. Sedation and mechanical ventilation may also be necessary. Withdrawal assessment scales such as the Clinical Institute of Withdrawal Assessment are of limited use in these patients. Instead, general sedation-agitation scales and delirium detection tools have been used. The important facets of care are the rapid identification of at-risk patients through histories of alcohol consumption, management with combination therapies, and ongoing diligent assessment and evaluation. (Critical Care Nurse. 2016;36[1]:28–39)

scholarly journals Alcohol withdrawal syndrome in ICU patients: Clinical features, management, and outcome predictors

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261443
Author(s):  
Aliénor Vigouroux ◽  
Charlotte Garret ◽  
Jean-Baptiste Lascarrou ◽  
Maëlle Martin ◽  
Arnaud-Félix Miailhe ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Delirium Tremens ◽  
Multivariable Analysis ◽  
Alcohol Withdrawal Syndrome ◽  
University Hospital ◽  
Icu Patients ◽  
Icu Admission ◽  
Organ Dysfunctions

Background Alcohol withdrawal syndrome (AWS) is a common condition in hospitalized patients, yet its epidemiology in the ICU remains poorly characterized. Methods Retrospective cohort of patients admitted to the Nantes University Hospital ICU between January 1, 2017, and December 31, 2019, and coded for AWS using ICD-10 criteria. The objective of the study was to identify factors associated with complicated hospital stay defined as ICU length of stay ≥7 days or hospital mortality. Results Among 5,641 patients admitted to the ICU during the study period, 246 (4.4%) were coded as having AWS. Among them, 42 had exclusion criteria and 204 were included in the study. The three main reasons for ICU admission were sepsis (29.9%), altered consciousness (29.4%), and seizures (24%). At ICU admission, median Cushman’s score was 6 [4–9] and median SOFA score was 3 [2–6]. Delirium tremens occurred in half the patients, seizures in one fifth and pneumonia in one third. Overall, 48% of patients developed complicated hospital stay, of whom 92.8% stayed in the ICU for ≥7 days, 36.7% received MV for ≥7 days, and 16.3% died during hospital stay. By multivariable analysis, two factors were associated with complicated hospital stay: a higher number of organ dysfunctions at ICU admission was associated with a higher risk of complicated hospital stay (OR, 1.18; 95CI, 1.05–1.32, P = 0.005), whereas ICU admission for seizures was associated with a lower risk of complicated hospital stay (OR, 0.14; 95%CI, 0.026–0.80; P = 0.026). Conclusions AWS in ICU patients chiefly affects young adults and is often associated with additional factors such as sepsis, trauma, or surgery. Half the patients experienced an extended ICU stay or death during the hospital stay. The likelihood of developing complicated hospital stay relied on the reason for ICU admission and the number of organ dysfunctions at ICU admission.

Lorazepam versus chlordiazepoxide for the treatment of alcohol withdrawal syndrome and prevention of delirium tremens in general medicine ward patients

Alcohol ◽  
2019 ◽  
Vol 81 ◽  
pp. 56-60
Author(s):  
Katherine L. March ◽  
Jennifer D. Twilla ◽  
Anne B. Reaves ◽  
Timothy H. Self ◽  
Melissa M. Slayton ◽  
...  
Keyword(s):  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Delirium Tremens ◽  
General Medicine ◽  
Alcohol Withdrawal Syndrome

Treatment of Acute Alcohol Withdrawal Syndrome with Carbamazepine: A Double-Blind Comparison with Tiapride

1982 ◽  
Vol 10 (3) ◽  
pp. 160-165 ◽  
Author(s):  
R Agricola ◽  
M Mazzarino ◽  
R Urani ◽  
V Gallo ◽  
E Grossi
Keyword(s):  
Visual Analogue Scale ◽  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Analogue Scale ◽  
Clinical Effect ◽  
Delirium Tremens ◽  
Alcohol Withdrawal Syndrome ◽  
Double Blind ◽  
Significant Difference ◽  
Blind Comparison

A double-blind, randomized trial is described which was designed to compare the clinical effect of 600 mg daily of carbamazepine (Tegretol®) and of tiapride (Sereprile®) in hospitalized patients with pre-delirium tremens. Physicians' assessment of patients' progress was made following 2, 4 and 7 days of treatment. Of the sixty patients admitted to the study, five dropped out for various reasons, leaving fifty-five patients who completed the study. Both drugs were effective in the treatment of alcohol withdrawal symptoms; no significant difference was found between the two treatments with respect to total symptoms' score and visual analogue scale assessment. Carbamazepine gave faster relief of symptoms and demonstrated a preferential action on symptoms like fear and hallucinations. No case of delirium tremens was observed in those patients who completed the trial.

scholarly journals Delirium tremens: early diagnosis and intensive care guidelines. Review

2020 ◽  
pp. 53-65
Author(s):  
A. Ye Muronov
Keyword(s):  
Intensive Care ◽  
Alcohol Consumption ◽  
Early Diagnosis ◽  
Hospital Stay ◽  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Delirium Tremens ◽  
Length Of Hospital Stay ◽  
Alcohol Withdrawal Syndrome ◽  
Care Guidelines

Alcoholic delirium is a formidable complication of severe alcohol withdrawal syndrome. It is often formed in patients of hospitals and departments of anesthesiology and intensive care, as a result of the forced cessation of alcohol consumption. Its formation is associated with an increase in the length of hospital stay and mortality. The review discusses modern approaches to the diagnosis, especially early, of this condition, its intensive care and methods of non-drug correction.

High‐Dose Gabapentin for the Treatment of Severe Alcohol Withdrawal Syndrome: A Retrospective Cohort Analysis

2019 ◽  
Vol 39 (9) ◽  
pp. 881-888 ◽  
Author(s):  
Alexander R. Levine ◽  
Lorna Carrasquillo ◽  
Jane Mueller ◽  
Mohamed Ismail Nounou ◽  
Edgar R. Naut ◽  
...  
Keyword(s):  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Retrospective Cohort ◽  
Cohort Analysis ◽  
Alcohol Withdrawal Syndrome ◽  
High Dose ◽  
Retrospective Cohort Analysis
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