scholarly journals On the Ultrastructure of Epithelial Cells in Bile Ducts of Cattle Chronically Infected with Fasciola Hepatica

1973 ◽  
Vol 14 (2) ◽  
pp. 233-244
Author(s):  
Timo Rahko
Keyword(s):  
Epithelial Cells ◽  
Bile Ducts ◽  
Fasciola Hepatica

scholarly journals Polarized human cholangiocytes release distinct populations of apical and basolateral small extracellular vesicles

2020 ◽  
Vol 31 (22) ◽  
pp. 2463-2474
Author(s):  
Brian A. Davies ◽  
Leslie O. Morton ◽  
John R. Jefferson ◽  
Cody N. Rozeveld ◽  
Luke C. Doskey ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Extracellular Vesicles ◽  
Bile Ducts ◽  
Extracellular Vesicle ◽  
Disease States

Human cholangiocytes, epithelial cells that line the bile ducts, were cultured as a model with which to study polarized small extracellular vesicle (sEV) communication. These cells release distinct sEV pools to mediate communication via their apical and basolateral domains. Furthermore, defective ESCRT function may contribute to disease states through altered sEV signaling.

A study of the initiation of biliary hyperplasia in rats infected with Fasciola hepatica

Parasitology ◽  
1981 ◽  
Vol 83 (2) ◽  
pp. 253-258 ◽  
Author(s):  
John R. Foster
Keyword(s):  
Bile Duct ◽  
Epithelial Cells ◽  
Common Bile Duct ◽  
Post Infection ◽  
Fasciola Hepatica ◽  
Mitogenic Effect ◽  
Mechanical Contact ◽  
Biliary Epithelium ◽  
The Common ◽  
Mechanical Irritation

SUMMARYFollowing infection of rats with Fasciola hepatica, an increase in the number of epithelial cells in the common bile duct, labelled with [3H]thymidine, was detected autoradiographically as early as 5 days post-infection (p.i.). This initial mitogenic effect of the infection was limited to that region of the bile duct lying adjacent to the liver, while the region lying next to the duodenum failed to show any increase in labelling until 41 days p.i. Mechanical contact between the parasite and the biliary epithelium did not occur until 41 days p.i. and the initial hyperplasia was evidently not a result of mechanical irritation. The study serves to emphasize the chemical aetiology of the precocious biliary hyperplasia and to more accurately identify its onset.

217304 Reconstruction of bile ducts by biliary epithelial cells in a PLGA membrane sandwich culture model

2011 ◽  
Vol 2011.17 (0) ◽  
pp. 445-446
Author(s):  
Kaoru MATSUUO ◽  
Tomoya KOMATSU ◽  
Toshihiro MITAKA ◽  
Mariko IKEDA ◽  
Ryo SUDO ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Bile Ducts ◽  
Biliary Epithelial Cells ◽  
Sandwich Culture ◽  
Culture Model

scholarly journals Experimental Mechanical Jaundice: Morphological Aspects of Proliferation, the Possibility of Transformation and Involution of Epithelial Cells in the Bile Ducts

2021 ◽  
Vol 7 (4) ◽  
pp. 98
Author(s):  
Asomidin Faizovich Sadriddinov ◽  
Sheraliev Kambarali Saidalievich ◽  
Hidirova Gulnoza Azodovna ◽  
Muborak Asomidinovna Sadriddinova ◽  
Elena Nikolaevna Guzacheva
Keyword(s):  
Epithelial Cells ◽  
Bile Ducts ◽  
Morphological Aspects

scholarly journals A Partially Protective Vaccine for Fasciola hepatica Induced Degeneration of Adult Flukes Associated to a Severe Granulomatous Reaction in Sheep

Animals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2869
Author(s):  
Verónica Molina-Hernández ◽  
María T. Ruiz-Campillo ◽  
Francisco J. Martínez-Moreno ◽  
Leandro Buffoni ◽  
Álvaro Martínez-Moreno ◽  
...  
Keyword(s):  
Bile Ducts ◽  
Plasma Cells ◽  
Fasciola Hepatica ◽  
Vaccine Trial ◽  
Granulomatous Inflammation ◽  
Giant Cells ◽  
Control Group ◽  
Infected Control Group ◽  
Hepatic Lesions ◽  
Host Parasite

Fasciolosis is an important economic disease of livestock. There is a global interest in the development of protective vaccines since current anthelmintic therapy is no longer sustainable. A better knowledge of the host-parasite interaction is needed for the design of effective vaccines. The present study evaluates the microscopical hepatic lesions in sheep immunized with a partially protective vaccine (VAC1), a non-protective vaccine (VAC2), and an infected control group (IC). The nature of granulomatous inflammation associated with degeneration of adult flukes found in the VAC1 group was characterized by immunohistochemistry. Hepatic lesions (fibrous perihepatitis, chronic tracts, bile duct hyperplasia, infiltration of eosinophils and lymphocytes and plasma cells) were significantly less severe in the VAC1 group than in the IC group. Dead adult flukes within bile ducts were observed only in the VAC1 group and were surrounded by a severe granulomatous inflammation composed by macrophages and multinucleate giant cells with a high expression of lysozyme, CD163 and S100 markers, and a low expression of CD68. Numerous CD3+ T lymphocytes and scarce infiltrate of FoxP3+ Treg and CD208+ dendritic cells were present. This is the first report describing degenerated flukes associated to a severe granulomatous inflammation in bile ducts in a F. hepatica vaccine trial.

Primary biliary cirrhosis

2010 ◽  
pp. 2464-2468
Author(s):  
M.F. Bassendine ◽  
D.E.J. Jones
Keyword(s):  
Liver Disease ◽  
Epithelial Cells ◽  
Primary Biliary Cirrhosis ◽  
Case History ◽  
Bile Ducts ◽  
Cholestatic Liver Disease ◽  
Biliary Cirrhosis ◽  
Blood Tests ◽  
Intrahepatic Bile Ducts ◽  
Immune Mediated

Case History—A 60 yr old woman presenting with abnormal liver blood tests. Primary biliary cirrhosis is a chronic, cholestatic liver disease in which the biliary epithelial cells lining the small intrahepatic bile ducts are the target for immune-mediated damage leading to progressive ductopenia. The cause is unknown, but presumed to be autoimmune....

scholarly journals Biliary Innate Immunity: Function and Modulation

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Kenichi Harada ◽  
Yasuni Nakanuma
Keyword(s):  
Innate Immunity ◽  
Epithelial Cells ◽  
Biliary Atresia ◽  
Th17 Cells ◽  
Bile Ducts ◽  
Innate Immune ◽  
Negative Regulator ◽  
Biliary Cirrhosis ◽  
Mesenchymal Transition ◽  
Biliary Epithelial Cells

Biliary innate immunity is involved in the pathogenesis of cholangiopathies in patients with primary biliary cirrhosis (PBC) and biliary atresia. Biliary epithelial cells possess an innate immune system consisting of the Toll-like receptor (TLR) family and recognize pathogen-associated molecular patterns (PAMPs). Tolerance to bacterial PAMPs such as lipopolysaccharides is also important to maintain homeostasis in the biliary tree, but tolerance to double-stranded RNA (dsRNA) is not found. In PBC, CD4-positive Th17 cells characterized by the secretion of IL-17 are implicated in the chronic inflammation of bile ducts and the presence of Th17 cells around bile ducts is causally associated with the biliary innate immune responses to PAMPs. Moreover, a negative regulator of intracellular TLR signaling, peroxisome proliferator-activated receptor-γ(PPARγ), is involved in the pathogenesis of cholangitis. Immunosuppression using PPARγligands may help to attenuate the bile duct damage in PBC patients. In biliary atresia characterized by a progressive, inflammatory, and sclerosing cholangiopathy, dsRNA viruses are speculated to be an etiological agent and to directly induce enhanced biliary apoptosis via the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Moreover, the epithelial-mesenchymal transition (EMT) of biliary epithelial cells is also evoked by the biliary innate immune response to dsRNA.

scholarly journals Canine hypertrophic osteopathy associated with extra-thoracic lesions

2005 ◽  
Vol 35 (4) ◽  
pp. 941-944 ◽  
Author(s):  
Selwyn Arlington Headley ◽  
Eduardo Alcântara Ribeiro ◽  
Gustavo José Von G. dos Santos ◽  
Carlos Maia Bettini ◽  
Ewaldo Mattos Júnior
Keyword(s):  
Epithelial Cells ◽  
Bile Ducts ◽  
Clinical Signs ◽  
Radiological Evaluation ◽  
Hydropic Degeneration ◽  
Biliary Stasis ◽  
Hepatic Lesions

Canine hypertrophic osteopathy is described in a dog that presented extra-thoracic lesions, mainly in the liver. Hepatic lesions were characterized by necrosis, hemorrhage, severe hydropic degeneration of centrolobular hepatocytes, proliferation of epithelial cells of bile ducts, and mild biliary stasis. The disease syndrome was diagnosed based on clinical signs, radiological evaluation, and inspection of macerated bones.

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