scholarly journals Iron Poisoning in Piglets Autopsy Findings in Experimental and Spontaneous Cases

1965 ◽  
Vol 6 (1) ◽  
pp. 360-373 ◽  
Author(s):  
Torsten Arpi ◽  
Gunnar Tollerz
Keyword(s):  
Autopsy Findings ◽  
Iron Poisoning

FERROUS SULFATE POISONING

PEDIATRICS ◽  
1952 ◽  
Vol 10 (6) ◽  
pp. 677-680
Author(s):  
LEROY K. BRANCH
Keyword(s):  
Body Weight ◽  
Case Report ◽  
Ferrous Sulfate ◽  
Fatal Case ◽  
Post Mortem ◽  
Potential Danger ◽  
Peripheral Vascular ◽  
Autopsy Findings ◽  
Iron Poisoning ◽  
Venous Thromboses

A fatal case of ferrous sulfate poisoning in a 29 month old boy, with autopsy findings, is recorded. He died approximately 4½ hours after ingestion of about seventy-five 0.3 gm. ferrous sulfate tablets (1.87 gm./kg. body weight). Signs of severe gastrointestinal irritation were followed by cyanosis and peripheral vascular collapse. Hemorrhagic gastroenteritis with mucosal slough and submucosal venous thromboses were demonstrated post mortem. Prevention and measures for correction of shock were emphasized in discussion of treatment. This case report should re-emphasize the potential danger of iron poisoning.

Acute Iron Poisoning in Children

1984 ◽  
Vol 4 (3) ◽  
pp. 575-586 ◽  
Author(s):  
Fred M. Henretig ◽  
Anthony R. Temple
Keyword(s):  
Iron Poisoning ◽  
Poisoning In Children

The Use of Radioiodinated Congo Red in the Study of Amyloidosis

1963 ◽  
Vol 03 (01) ◽  
pp. 25-38
Author(s):  
Manuel Tubis ◽  
William Blahd ◽  
John Endow
Keyword(s):  
Rheumatoid Arthritis ◽  
Multiple Myeloma ◽  
Comparative Studies ◽  
Congo Red ◽  
Half Time ◽  
Positive Correlation ◽  
Autopsy Findings ◽  
Percentage Removal

SummaryA study of the removal of I131-labeled Congo red from the blood of amyloid, non-amyloid, multiple myeloma, rheumatoid arthritis and other patients is presented. The percentage removal of the labeled dye shows the same variation reported by many other workers using Bennhold’s test and its modifications.However, there seems to be a positive correlation between the percentage removal of the labeled dye and the presence of amyloid as revealed by biopsy and autopsy. The half-time of disappearance is also correlated with the amyloidosis.The availability of the I131-labeled dye permits the use of very small weights of the dye thereby drastically reducing the possibility of toxic and sometimes fatal reactions encountered with the unlabeled dye. The I131 present permits easy quantitation of the dye in the blood without separation of plasma and obviates the need of fasting. It also permits external counting and scanning of deposits in the organs containing the dye.The availability and use of the labeled dye may stimulate more comparative studies of the removal of the dye from the blood correlated with biopsy and autopsy findings.

Body Distribution of Lipiodol 131J Following Intralymphatic Radiotherapy

1965 ◽  
Vol 05 (01) ◽  
pp. 1-11
Author(s):  
G. Fava ◽  
L. Roncoroni
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
General Introduction ◽  
Autopsy Findings ◽  
Body Distribution ◽  
Exact Data ◽  
Radioisotope Therapy

SummaryAn account is given of the principles of lymph node dosimetry in radioisotope therapy with Lipiodol 131J. After a general introduction, exact data on the concentrations reached by the radionuclide in the lymph nodes, liver, spleen, thyroid and blood of patients subjected to this treatment are reported. Finally mention is made of a number of particularly interesting autopsy findings.

scholarly journals Secondary haemophagocytic lymphohistiocytosis in COVID-19: correlation of the autopsy findings of bone marrow haemophagocytosis with HScore

2021 ◽  
pp. jclinpath-2020-207337
Author(s):  
Claudia Núñez-Torrón ◽  
Ana Ferrer-Gómez ◽  
Esther Moreno Moreno ◽  
Belen Pérez-Mies ◽  
Jesús Villarrubia ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Immune Response ◽  
Immune System ◽  
Multiorgan Failure ◽  
Histological Findings ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Bone Marrow Tissue ◽  
Autopsy Findings ◽  
Specific Finding ◽  
Clinical Records

BackgroundSecondary haemophagocytic lymphohistiocytosis (sHLH) is characterised by a hyper activation of immune system that leads to multiorgan failure. It is suggested that excessive immune response in patients with COVID-19 could mimic this syndrome. Some COVID-19 autopsy studies have revealed the presence of haemophagocytosis images in bone marrow, raising the possibility, along with HScore parameters, of sHLH.AimOur objective is to ascertain the existence of sHLH in some patients with severe COVID-19.MethodsWe report the autopsy histological findings of 16 patients with COVID-19, focusing on the presence of haemophagocytosis in bone marrow, obtained from rib squeeze and integrating these findings with HScore parameters. CD68 immunohistochemical stains were used to highlight histiocytes and haemophagocytic cells. Clinical evolution and laboratory parameters of patients were collected from electronic clinical records.ResultsEleven patients (68.7%) displayed moderate histiocytic hyperplasia with haemophagocytosis (HHH) in bone marrow, three patients (18.7%) displayed severe HHH and the remainder were mild. All HScore parameters were collected in 10 patients (62.5%). Among the patients in which all parameters were evaluable, eight patients (80%) had an HScore >169. sHLH was not clinically suspected in any case.ConclusionsOur results support the recommendation of some authors to use the HScore in patients with severe COVID-19 in order to identify those who could benefit from immunosuppressive therapies. The presence of haemophagocytosis in bone marrow tissue, despite not being a specific finding, has proved to be a very useful tool in our study to identify these patients.

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