scholarly journals High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome

2005 ◽  
Vol 7 (2) ◽  
Author(s):  
Klaus Jürgen Schmitz ◽  
Florian Grabellus ◽  
Rainer Callies ◽  
Friedrich Otterbach ◽  
Jeremias Wohlschlaeger ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
High Expression ◽  
Akt Kinase ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Her 2

Prognostic significance of Focal Adhesion Kinase (FAK) in node-negative breast cancer.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 552-552
Author(s):  
Marcus Schmidt ◽  
Leonie van de Sandt ◽  
Katrin Almstedt ◽  
Marco Johannes Battista ◽  
Anne-Sophie Heimes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Prognostic Significance ◽  
Node Negative ◽  
Node Negative Breast Cancer

scholarly journals Long-term prognostic significance of HER-2/neu in untreated node-negative breast cancer depends on the method of testing

2005 ◽  
Vol 7 (2) ◽  
Author(s):  
Marcus Schmidt ◽  
Barbara Lewark ◽  
Nikolai Kohlschmidt ◽  
Christiane Glawatz ◽  
Erik Steiner ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Significance ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Her 2

High expression of 90K (Mac-2 BP) is associated with poor survival in node-negative breast cancer patients not receiving adjuvant systemic therapies

2009 ◽  
Vol 124 (2) ◽  
pp. 333-338 ◽  
Author(s):  
Nicola Tinari ◽  
Rossano Lattanzio ◽  
Patrizia Querzoli ◽  
Clara Natoli ◽  
Antonino Grassadonia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
High Expression ◽  
Breast Cancer Patients ◽  
Poor Survival ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Systemic Therapies

Clinical relevance of HER-2 expression in node-negative breast cancer patients

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 598-598
Author(s):  
J. M. Sun ◽  
W. Han ◽  
D. W. Kim ◽  
T. Y. Kim ◽  
I. A. E. Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Clinical Relevance ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Her 2

Clinical relevance of HER-2 expression in node-negative breast cancer patients

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 598-598
Author(s):  
J. M. Sun ◽  
W. Han ◽  
D. W. Kim ◽  
T. Y. Kim ◽  
I. A. E. Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Clinical Relevance ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Her 2

scholarly journals Prognostic Significance of Focal Adhesion Kinase in Node-Negative Breast Cancer

Breast Care ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. 329-333 ◽  
Author(s):  
Katrin Almstedt ◽  
Isabel Sicking ◽  
Marco J. Battista ◽  
Shangou Huangfu ◽  
Anne-Sophie Heimes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Cox Regression ◽  
Prognostic Impact ◽  
Free Survival ◽  
Node Negative ◽  
Cox Regression Analysis ◽  
Luminal B ◽  
Prognostic Relevance

Background: Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays an important role as a mediator of cell migration, invasion, proliferation and survival. Conflicting results for the prognostic role of FAK in breast cancer (BC) prompted us to determine its impact. Methods: Patients with node-negative BC entered this retrospective study. FAK expression was determined by immunohistochemistry (n = 335). The prognostic impact of FAK was examined with Cox regression analyses and Kaplan-Meier estimation in the whole cohort as well as in different molecular subtypes. Results: 151 (45.1%) had a FAK-positive BC. In univariate analyses, FAK expression showed a significant impact for shorter disease-free survival (DFS) (hazard ratio (HR) 1.54, 95% confidence interval (CI) 1.04-2.28, p = 0.030) but not for metastasis-free survival and overall survival. Significant prognostic relevance for DFS (HR 1.76, 95% CI 1.05-2.97, p = 0.033) was observed in particular in estrogen receptor-positive HER2-negative BC patients, most notably in luminal B-like tumors (HR 2.32, CI 1.20-4.48, p = 0.012). However, FAK lost its prognostic impact in multivariate Cox regression analysis. Conclusion: FAK was associated with impaired DFS in univariate analysis. Prognostic relevance for DFS was most pronounced in luminal B-like BC. However, FAK expression was not associated with an independent impact on survival for BC in multivariate analysis.

HER-2 Expression and Cell Proliferation: Prognostic Markers in Patients With Node-Negative Breast Cancer

2003 ◽  
Vol 21 (14) ◽  
pp. 2708-2712 ◽  
Author(s):  
Annalisa Volpi ◽  
Oriana Nanni ◽  
Franca De Paola ◽  
Anna Maria Granato ◽  
Annita Mangia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Proliferative Activity ◽  
Case Series ◽  
Locoregional Therapy ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
National Quality ◽  
Her 2

Purpose: We analyzed the clinical relevance of HER-2 expression, widely investigated in breast cancer but with contradictory results, in the largest case series of node-negative breast cancer patients investigated to date. Patients and Methods: The pure prognostic value of HER-2 expression was investigated in 529 patients treated with locoregional therapy alone until early relapse. Proliferative activity was evaluated as [ 3 H]thymidine labeling index and HER-2 expression by immunohistochemistry. All biologic determinations were conducted within the context of an intra- and interlaboratory National Quality Control Program. Results: HER-2 expression was not related to relapse-free survival in the overall series but was a significant discriminant of prognosis in the subgroup of patients with rapidly proliferating tumors. Six-year rate of relapse was 40% for patients with highly (≥30%) positive tumors and 26% for those with weakly HER-2-expressing tumors (P = .039). Conclusion: HER-2 expression in association with proliferative activity identifies a subgroup of node-negative breast cancer patients with the worst prognosis, who are candidates for specific intensive adjuvant therapy.

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