scholarly journals Germline mutations in DNA repair and cell cycle checkpoint genes: consequential somatic gene alterations and genome instability

2003 ◽  
Vol 5 (S1) ◽  
Author(s):  
S Ingvarsson
Keyword(s):  
Cell Cycle ◽  
Dna Repair ◽  
Genome Instability ◽  
Germline Mutations ◽  
Cell Cycle Checkpoint ◽  
Somatic Gene ◽  
Cycle Checkpoint ◽  
Checkpoint Genes ◽  
Gene Alterations

Cell Cycle Checkpoint Genes and Aneuploidy: A Short Review

2001 ◽  
Vol 2 (2) ◽  
pp. 171-180 ◽  
Author(s):  
William Kearns ◽  
Johnson Liu
Keyword(s):  
Cell Cycle ◽  
Short Review ◽  
Cell Cycle Checkpoint ◽  
Cycle Checkpoint ◽  
Checkpoint Genes

scholarly journals DNA repair and cell cycle checkpoint defects in a mouse model of ‘BRCAness’ are partially rescued by 53BP1 deletion

Cell Cycle ◽  
2018 ◽  
Vol 17 (7) ◽  
pp. 881-891 ◽  
Author(s):  
Sarah M. Misenko ◽  
Dharm S. Patel ◽  
Joonyoung Her ◽  
Samuel F. Bunting
Keyword(s):  
Cell Cycle ◽  
Dna Repair ◽  
Mouse Model ◽  
Cell Cycle Checkpoint ◽  
Cycle Checkpoint

scholarly journals ALDH1A1 Maintains Ovarian Cancer Stem Cell-Like Properties by Altered Regulation of Cell Cycle Checkpoint and DNA Repair Network Signaling

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107142 ◽  
Author(s):  
Erhong Meng ◽  
Aparna Mitra ◽  
Kaushlendra Tripathi ◽  
Michael A. Finan ◽  
Jennifer Scalici ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Ovarian Cancer ◽  
Dna Repair ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Cycle Checkpoint ◽  
Cycle Checkpoint ◽  
Altered Regulation ◽  
Regulation Of Cell Cycle

scholarly journals Inhibition of DNA Repair in Cancer Therapy: Toward a Multi-Target Approach

2020 ◽  
Vol 21 (18) ◽  
pp. 6684
Author(s):  
Samuele Lodovichi ◽  
Tiziana Cervelli ◽  
Achille Pellicioli ◽  
Alvaro Galli
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Dna Repair ◽  
Cancer Therapy ◽  
Clinical Outcome ◽  
Cancer Cells ◽  
Cell Cycle Checkpoint ◽  
Normal Cells ◽  
Cycle Checkpoint ◽  
Repair Pathways

Alterations in DNA repair pathways are one of the main drivers of cancer insurgence. Nevertheless, cancer cells are more susceptible to DNA damage than normal cells and they rely on specific functional repair pathways to survive. Thanks to advances in genome sequencing, we now have a better idea of which genes are mutated in specific cancers and this prompted the development of inhibitors targeting DNA repair players involved in pathways essential for cancer cells survival. Currently, the pivotal concept is that combining the inhibition of mechanisms on which cancer cells viability depends is the most promising way to treat tumorigenesis. Numerous inhibitors have been developed and for many of them, efficacy has been demonstrated either alone or in combination with chemo or radiotherapy. In this review, we will analyze the principal pathways involved in cell cycle checkpoint and DNA repair focusing on how their alterations could predispose to cancer, then we will explore the inhibitors developed or in development specifically targeting different proteins involved in each pathway, underscoring the rationale behind their usage and how their combination and/or exploitation as adjuvants to classic therapies could help in patients clinical outcome.

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