scholarly journals Tyrosine kinase signalling in breast cancer: Fibroblast growth factors and their receptors

10.1186/bcr53 ◽  
2000 ◽  
Vol 2 (3) ◽  
Author(s):  
Clive Dickson ◽  
Bradley Spencer-Dene ◽  
Christian Dillon ◽  
Vera Fantl
Keyword(s):  
Breast Cancer ◽  
Growth Factors ◽  
Tyrosine Kinase ◽  
Fibroblast Growth Factors ◽  
Fibroblast Growth

scholarly journals Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo.

1988 ◽  
Vol 263 (2) ◽  
pp. 988-993 ◽  
Author(s):  
S R Coughlin ◽  
P J Barr ◽  
L S Cousens ◽  
L J Fretto ◽  
L T Williams
Keyword(s):  
Growth Factors ◽  
Tyrosine Kinase ◽  
Kinase Activity ◽  
Fibroblast Growth Factors ◽  
Fibroblast Growth ◽  
Tyrosine Kinase Activity

Structural and functional specificity of FGF receptors

1993 ◽  
Vol 340 (1293) ◽  
pp. 297-303 ◽  
Keyword(s):  
Growth Factors ◽  
Cell Surface ◽  
Tyrosine Kinase ◽  
Heparan Sulphate ◽  
Fibroblast Growth Factors ◽  
Binding Property ◽  
Fibroblast Growth ◽  
Heparin Binding ◽  
Kinase Gene ◽  
Receptor System

Fibroblast growth factors (FGFs) represent a group of polypeptide mitogens eliciting a wide variety of responses depending on the target cell type. The knowledge of the cell surface receptors mediating the effects of FGFs has recently expanded remarkably. Perhaps not surprisingly, the complexity of the FGF family and FGF induced responses is reflected in the diversity and redundancy of the FGF receptors. The molecular cloning of the signal transducing receptors for fibroblast growth factors has revealed a tyrosine kinase gene family with at least four members. Differential splicing and polyadenylation creates further diversity in the FGF receptor system. These numerous receptor forms have both distinct and redundant properties. We are only now beginning to understand how the different receptors are activated by the various FGFs and how they are expressed by various cells and tissues. FGF binding to the tyrosine kinase receptors needs the assistance of heparan sulphate side chains of proteoglycans present at the cell surface and in the extracellular matrix. As several other growth factors share the heparin binding property of FGFs, the dual receptor system for FGFs might be an example of a more widely used principle.

0-93. Autocrine and paracrine stimulation of breast cancer by fibroblast growth factors

The Breast ◽  
1997 ◽  
Vol 6 (4) ◽  
pp. 250-251
Author(s):  
S. Marsh ◽  
C. Johnston ◽  
J. Gomm ◽  
C. Zammit ◽  
H. Sinnett ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factors ◽  
Fibroblast Growth Factors ◽  
Fibroblast Growth ◽  
Stimulation Of

scholarly journals The Estimate of Cytokines and Fibroblast Growth Factors in Patients with Breast Cancer

2020 ◽  
Vol 22 (2) ◽  
pp. 9-16
Author(s):  
Shvan Burhan Rafiq ◽  
◽  
Heshu Sulaiman Rahman ◽  
Kawa Amin ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factors ◽  
Fibroblast Growth Factors ◽  
Fibroblast Growth

scholarly journals Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0185736 ◽  
Author(s):  
Kelly Aukes ◽  
Cynthia Forsman ◽  
Nicholas J. Brady ◽  
Kristina Astleford ◽  
Nicholas Blixt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factors ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Fibroblast Growth Factors ◽  
Fibroblast Growth ◽  
Osteoclast Activity ◽  
Metastatic Lesions
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