scholarly journals BRCA1 and BRCA2 mutations in a population-based study of male breast cancer

2001 ◽  
Vol 4 (1) ◽  
Author(s):  
Victoria M Basham ◽  
Julian M Lipscombe ◽  
Joanna M Ward ◽  
Simon A Gayther ◽  
Bruce AJ Ponder ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Population Based ◽  
Male Breast ◽  
Brca1 And Brca2 ◽  
Population Based Study ◽  
Brca2 Mutations ◽  
Brca1 And Brca2 Mutations

Prevalence of BRCA1 and BRCA2 Mutations in Male Breast Cancer Patients in Canada

2000 ◽  
Vol 1 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Natalie Wolpert ◽  
Ellen Warner ◽  
Maureen F. Seminsky ◽  
Andrew Futreal ◽  
Steven A. Narod
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Male Breast Cancer ◽  
Male Breast ◽  
Breast Cancer Patients ◽  
Brca1 And Brca2 ◽  
Brca2 Mutations ◽  
Brca1 And Brca2 Mutations

scholarly journals Breast Cancer Risk for Noncarriers of Family-Specific BRCA1 and BRCA2 Mutations: Findings From the Breast Cancer Family Registry

2011 ◽  
Vol 29 (34) ◽  
pp. 4505-4509 ◽  
Author(s):  
Allison W. Kurian ◽  
Gail D. Gong ◽  
Esther M. John ◽  
David A. Johnston ◽  
Anna Felberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Brca2 Mutation ◽  
Population Based ◽  
Brca1 And Brca2 ◽  
Breast Cancer Family ◽  
Cancer Family ◽  
Brca2 Mutations ◽  
Brca1 And Brca2 Mutations

Purpose Women with germline BRCA1 and BRCA2 mutations have five- to 20-fold increased risks of developing breast and ovarian cancer. A recent study claimed that women testing negative for their family-specific BRCA1 or BRCA2 mutation (noncarriers) have a five-fold increased risk of breast cancer. We estimated breast cancer risks for noncarriers by using a population-based sample of patients with breast cancer and their female first-degree relatives (FDRs). Patients and Methods Patients were women with breast cancer and their FDRs enrolled in the population-based component of the Breast Cancer Family Registry; patients with breast cancer were tested for BRCA1 and BRCA2 mutations, as were FDRs of identified mutation carriers. We used segregation analysis to fit a model that accommodates familial correlation in breast cancer risk due to unobserved shared risk factors. Results We studied 3,047 families; 160 had BRCA1 and 132 had BRCA2 mutations. There was no evidence of increased breast cancer risk for noncarriers of identified mutations compared with FDRs from families without BRCA1 or BRCA2 mutations: relative risk was 0.39 (95% CI, 0.04 to 3.81). Residual breast cancer correlation within families was strong, suggesting substantial risk heterogeneity in women without BRCA1 or BRCA2 mutations, with some 3.4% of them accounting for roughly one third of breast cancer cases. Conclusion These results support the practice of advising noncarriers that they do not have any increase in breast cancer risk attributable to the family-specific BRCA1 or BRCA2 mutation.

scholarly journals Effects of HER2 status on the prognosis of male breast cancer: a population-based study

2019 ◽  
Vol Volume 12 ◽  
pp. 7251-7260 ◽  
Author(s):  
Liang Chen ◽  
Yi Ming Weng ◽  
Meng Xue Hu ◽  
Min Peng ◽  
Qi bin Song
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Population Based ◽  
Male Breast ◽  
Her2 Status ◽  
Population Based Study
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